Search Results - "Wilhelm, Olaf G"

PITX2 DNA-Methylation: Predictive versus Prognostic Value for Anthracycline-Based Chemotherapy in Triple-Negative Breast Cancer Patients by Napieralski, Rudolf, Schricker, Gabriele, Auer, Gert, Aubele, Michaela, Perkins, Jonathan, Magdolen, Viktor, Ulm, Kurt, Hamann, Moritz, Walch, Axel, Weichert, Wilko, Kiechle, Marion, Wilhelm, Olaf G.

“…Background: PITX2 DNA methylation has been shown to predict outcomes in high-risk breast cancer patients after anthracycline-based chemotherapy. To determine…”
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Clinical performance of an analytically validated assay in comparison to microarray technology to assess PITX2 DNA-methylation in breast cancer by Schricker, Gabriele, Napieralski, Rudolf, Noske, Aurelia, Piednoir, Elodie, Manner, Olivia, Schüren, Elisabeth, Lauber, Jürgen, Perkins, Jonathan, Magdolen, Viktor, Schmitt, Manfred, Ulm, Kurt, Weichert, Wilko, Kiechle, Marion, Martens, John W. M., Wilhelm, Olaf G.

“…Significant evidence has accumulated that DNA-methylation of the paired-like homeodomain transcription factor 2 ( PITX2 ) gene can serve as a prognostic and…”
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Prognosis and Prediction in Breast Cancer: Is There a Need for Further Tests? by Wilhelm, Olaf G, Kiechle, Marion

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The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges by Wilhelm, Olaf G., Kiechle, Marion, Foekens, John A., Magdolen, Viktor, Absmaier, Magdalena, Ettl, Johannes, Paepke, Stefan, Napieralski, Rudolf, Schmitt, Manfred, Aubele, Michaela, Martens, John

“…High-risk breast cancer comprises distinct tumor entities such as triple-negative breast cancer (TNBC) which is characterized by lack of estrogen (ER) and…”
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Clinical Validation of PITX2 DNA Methylation to Predict Outcome in High-Risk Breast Cancer Patients Treated with Anthracycline-Based Chemotherapy by Schmitt, Manfred, Wilhelm, Olaf G., Noske, Aurelia, Schricker, Gabriele, Napieralski, Rudolph, Vetter, Martina, Aubele, Michaela, Perkins, Jonathan, Lauber, Jürgen, Ulm, Kurt, Thomssen, Christoph, Martens, John W.M., Weichert, Wilko, Kiechle, Marion

“…Background: Breast cancer patients at high risk for recurrence are treated with anthracycline-based chemotherapy, but not all patients do equally benefit from…”
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Synthesis, Solution Structure, and Biological Evaluation of Urokinase Type Plasminogen Activator (uPA)-Derived Receptor Binding Domain Mimetics by Schmiedeberg, Niko, Schmitt, Manfred, Rölz, Christian, Truffault, Vincent, Sukopp, Martin, Bürgle, Markus, Wilhelm, Olaf G, Schmalix, Wolfgang, Magdolen, Viktor, Kessler, Horst

“…Tumor cell migration and metastasis in cancer are facilitated by interaction of the serine protease urokinase type plasminogen activator (uPA) with its…”
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(4-Aminomethyl)Phenylguanidine Derivatives as Nonpeptidic Highly Selective Inhibitors of Human Urokinase by Sperl, Stefan, Jacob, Uwe, De Prada, Nuria Arroyo, Sturzebecher, Jorg, Wilhelm, Olaf G., Bode, Wolfram, Magdolen, Viktor, Huber, Robert, Moroder, Luis

“…Increased expression of the serine protease urokinase-type plasminogen activator (uPA) in tumor tissues is highly correlated with tumor cell migration,…”
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Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression by Wilhelm, Olaf G., Wilhelm, Sabine, Escott, Gemma M., Lutz, Verena, Magdolen, Viktor, Schmitt, Manfred, Rifkin, Daniel B., Wilson, E. Lynette, Graeff, Henner, Brunner, Georg

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Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinase-type plasminogen activator receptor (CD87) by Krüger, A, Soeltl, R, Lutz, V, Wilhelm, O G, Magdolen, V, Rojo, E E, Hantzopoulos, P A, Graeff, H, Gänsbacher, B, Schmitt, M

“…The serine protease urokinase-type plasminogen activator, uPA, when bound to its specific receptor, uPAR (CD87), plays a significant role in tumor cell…”
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Abstract P3-08-65: PITX2 DNA methylation: A prognostic/predictive biomarker for anthracycline-based chemotherapy by Kiechle, Marion, Schricker, Gabriele, Napieralski, Rudolf, Aubele, Michaela, Auer, Gert, Ulm, Kurt, Perkins, Jonathan, Paepke, Stefan, Hamann, Moritz, Wilhelm, Olaf G.

“…Background: Published data on the basis of a research-use-only PITX2 methylation assay using fresh-frozen tissue showed that the PITX2 DNA methylation may be a…”
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Epitope Mapping of Monoclonal Antibodies Directed to PAI-1 Using PAI-1/PAI-2 Chimera and PAI-1-Derived Synthetic Peptides by Muehlenweg, Bernd, Guthaus, Elke, de Prada, Nuria Arroyo, Schmitt, Manfred, Schmiedeberg, Niko, Kotzsch, Matthias, Creutzburg, Sabine, Kramer, Michael D, Kessler, Horst, Wilhelm, Olaf G, Magdolen, Viktor

“…Plasminogen activator inhibitor type-1 is a key regulatory protein of the fibrinolytic system that is involved in a variety of physiological and…”
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Interaction of plasminogen activator inhibitor type‐1 (PAI‐1) with vitronectin by Arroyo De Prada, Nuria, Schroeck, Florian, Sinner, Eva‐Kathrin, Muehlenweg, Bernd, Twellmeyer, Jens, Sperl, Stefan, Wilhelm, Olaf G., Schmitt, Manfred, Magdolen, Viktor

“…The serpin plasminogen activator inhibitor type 1 (PAI‐1) plays an important role in physiological processes such as thrombolysis and fibrinolysis, as well as…”
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The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells by Kanse, Sandip M., Kost, Christine, Wilhelm, Olaf G., Andreasen, Peter A., Preissner, Klaus T.

“…We have previously demonstrated that vitronectin (VN), a morphoregulatory protein in the vessel wall, is internalized and translocated to the subendothelial…”
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PITX2 DNA-methylation as the first clinically validated predictive marker for anthracycline based chemotherapy in high-risk breast cancer patients by Schmitt, Manfred, Wilhelm, Olaf G., Napieralski, Rudolf, Schricker, Gabriele, Kiechle, Marion

“…International guidelines recommend anthracycline-based chemotherapy for high-risk breast cancer patients as the standard-of-care, but not all patients do…”
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Entwicklungen der forschenden Pharmaindustrie by Thomssen, Christoph, Gnant, Michael, Harbeck, Nadia

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Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator by Magdolen, V, Arroyo de Prada, N, Sperl, S, Muehlenweg, B, Luther, T, Wilhelm, O G, Magdolen, U, Graeff, H, Reuning, U, Schmitt, M

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Thrombomodulin, a receptor for the serine protease thrombin, is decreased in primary tumors and metastases but increased in ascitic fluids of patients with advanced ovarian cancer FIGO IIIc by Wilhelm, S, Schmitt, M, Parkinson, J, Kuhn, W, Graeff, H, Wilhelm, O G

“…The human ovarian cancer cell line OV-MZ-19, established from a patient with cystadenocarcinoma of the ovary, expressing thrombomodulin (TM), a cell surface…”
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Interaction of plasminogen activator inhibitor type‐1 (PAI‐1) with vitronectin: Characterization of different PAI‐1 mutants by Arroyo De Prada, Nuria, Schroeck, Florian, Sinner, Eva‐Kathrin, Muehlenweg, Bernd, Twellmeyer, Jens, Sperl, Stefan, Wilhelm, Olaf G., Schmitt, Manfred, Magdolen, Viktor

“…The serpin plasminogen activator inhibitor type 1 (PAI‐1) plays an important role in physiological processes such as thrombolysis and fibrinolysis, as well as…”
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Cellular glycosylphosphatidylinositol‐specific phospholipase D regulates urokinase receptor shedding and cell surface expression by Wilhelm, Olaf G., Wilhelm, Sabine, Escott, Gemma M., Lutz, Verena, Magdolen, Viktor, Schmitt, Manfred, Rifkin, Daniel B., Wilson, E. Lynette, Graeff, Henner, Brunner, Georg

“…The glycosylphosphatidylinositol (GPI) ‐ anchored, multifunctional receptor for the serine proteinase, urokinase plasminogen activator (uPAR, CD87), regulates…”
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Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) by Magdolen, V, Bürgle, M, de Prada, N A, Schmiedeberg, N, Riemer, C, Schroeck, F, Kellermann, J, Degitz, K, Wilhelm, O G, Schmitt, M, Kessler, H

“…Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and…”
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