Search Results - "Wilhelm, Gaus"

Cross matching observations on toxicological and clinical data for the assessment of tolerability and safety of Ginkgo biloba leaf extract by Heinonen, Tuula, Gaus, Wilhelm

“…Highlights • Cross-matching of toxicological, clinical and other data improves risk analysis. • Induction of drug metabolism is linked to increased cell…”
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Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice by Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E, Sandanger, Øystein, Nilsson, Per H, Nunn, Miles A, Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E

“…Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system…”
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Riluzole in Huntington's disease: a 3-year, randomized controlled study by Landwehrmeyer, G. Bernhard, Dubois, Bruno, de Yébenes, Justo Garcia, Kremer, Berry, Gaus, Wilhelm, Kraus, Peter H., Przuntek, Horst, Dib, Michel, Doble, Adam, Fischer, Wilhelm, Ludolph, Albert C.

“…Objective We conducted a randomized double‐blind trial of riluzole in Huntington's disease to investigate the efficacy of this antiexcitotoxic drug in slowing…”
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Risk factors for alveolar echinococcosis in humans by Kern, Petra, Ammon, Andrea, Kron, Martina, Sinn, Gabriele, Sander, Silvia, Petersen, Lyle R, Gaus, Wilhelm, Kern, Peter

“…We conducted a case-control study to investigate risk factors for acquiring autochthonous alveolar echinococcosis in Germany. Forty cases and 120 controls…”
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STATISTICAL CONSIDERATIONS FOR LOT-BY-LOT ACCEPTANCE/REJECTION SAMPLING WITH AN ATTRIBUTE by Gaus, Wilhelm, Muche, Rainer, Mayer, Benjamin

“…The standard procedure for lot-by-lot acceptance/rejection sampling described in literature makes always a decision. If there are more invalid items in the…”
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Which level of evidence does the US National Toxicology Program provide? Statistical considerations using the Technical Report 578 on Ginkgo biloba as an example by Gaus, Wilhelm

“…•Statistical considerations on the US National Toxicology Program (NTP).•The Technical Report TR 578 on Ginkgo biloba was selected as an example.•It reports on…”
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Role of octreotide in the prevention of postoperative complications following pancreatic resection by Büchler, M, Friess, H, Klempa, I, Hermanek, P, Sulkowski, U, Becker, H, Schafmayer, A, Baca, I, Lorenz, D, Meister, R

“…Though morbidity and mortality rates following pancreatic resection have improved in recent years, they are still around 35% and 5%, respectively. Typical…”
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An example for an underpowered study: a comment on Ginkgo biloba for mild to moderate dementia in a community setting by McCarney et al by Gaus, Wilhelm

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Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma by Hunzelmann, Nicolas, Anders, Sabine, Fierlbeck, Gerhard, Hein, Rüdiger, Herrmalm, Konrad, Albrecht, Manuela, Bell, Sabine, Muche, Rainer, Wehner-Caroli, Jörg, Gaus, Wilhelm, Krieg, Thomas

“…Localized scleroderma is characterized by circumscribed fibrotic plaques and may progress to widespread skin involvement and fibrosis. Interferon gamma (IFN-γ)…”
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Is a controlled randomised trial the non-plus-ultra design? A contribution to discussion on comparative, controlled, non-randomised trials by Gaus, Wilhelm, Muche, Rainer

“…Abstract Background Clinical studies provide formalised experience for evidence-based medicine (EBM). Many people consider a controlled randomised trial (CRT,…”
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Treatment with benfotiamine in patients with diabetic sensorimotor polyneuropathy: A double-blind, randomized, placebo-controlled, parallel group pilot study over 12 months by Stirban, Ovidiu Alin, Zeller-Stefan, Helga, Schumacher, Jochen, Gaus, Wilhelm, Ziegler, Dan, Schuerholz, Thomas, Pop-Busui, Rodica

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Safety aspects of Chinese herbal medicine in pregnancy—Re-evaluation of experimental data of two animal studies and the clinical experience by Wiebrecht, Axel, Gaus, Wilhelm, Becker, Simon, Hummelsberger, Josef, Kuhlmann, Kirsten

“…Highlights • Pregnancy risks of CHM must conform to modern safety requirements. • Standard textbooks relating to risks of CHM during pregnancy are unreliable…”
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The efficacy and safety of Crataegus extract WS® 1442 in patients with heart failure: The SPICE trial by Holubarsch, Christian J.F., Colucci, Wilson S., Meinertz, Thomas, Gaus, Wilhelm, Tendera, Michal

“…Background: Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an…”
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Patient-centered developments in colon- and rectal cancer with a multidisciplinary international team: From translational research to national guidelines by Link, Karl-Heinrich, Kornmann, Marko, Staib, Ludger, Kreuser, Ernst-Dietrich, Gaus, Wilhelm, Röttinger, Erwin, Suhr, Peter, Maulbecker-Armstrong, Catharina, Danenberg, Peter, Danenberg, Kathleen, Schatz, Miriam, Sander, Silvia, Ji, Zhen-Ling, Li, Jiang-Tao, Peng, Shu-You, Bittner, Reinhard, Beger, Hans Günther, Traub, Benno

“…Rarely, scientific developments centered around the patient as a whole are published. Our multidisciplinary group, headed by gastrointestinal surgeons, applied…”
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Meta-analysis of the efficacy of the acetonic kava-kava extract WS®1490 in patients with non-psychotic anxiety disorders by Witte, Steffen, Loew, Dieter, Gaus, Wilhelm

“…Introduction: The herbal medicinal product kava‐kava, used for treating anxiety disorders, was assessed positively by the Cochrane Review. However, it was…”
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Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate? by Butterweck, Veronika, Derendorf, Hartmut, Gaus, Wilhelm, Nahrstedt, Adolf, Schulz, Volker, Unger, Matthias

“…Pharmacokinetic interactions often occur as a result of activity changes of drug-metabolizing and transporting proteins, especially cytochrome P450 (CYP)…”
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Medical Statistics – Mathematics or Oracle? Farewell Lecture by Gaus, Wilhelm

“…Certainty is rare in medicine. This is a direct consequence of the individuality of each and every human being and the reason why we need medical statistics…”
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Ultrasonographically detected gallbladder polyps: a reason for concern? A seven-year follow-up study by Kratzer, Wolfgang, Haenle, Mark M, Voegtle, Andrea, Mason, Richard A, Akinli, Atilla S, Hirschbuehl, Klaus, Schuler, Andreas, Kaechele, Volker

“…The management of coincidental detected gallbladder polyps (GP) is still nebulous. There are few published data regarding their long-term growth. Objective of…”
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Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis by Kassubek, Jan, Gaus, Wilhelm, Landwehrmeyer, G Bernard

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Haemodialysis-membrane biocompatibility and mortality of patients with dialysis-dependent acute renal failure: a prospective randomised multicentre trial by Jörres, Achim, Gahl, Gerhard M, Dobis, Clemens, Polenakovic, Momir H, Cakalaroski, Koco, Rutkowski, Boleslaw, Kisielnicka, Ewa, Krieter, Detlef H, Wolfgang Rumpf, K, Guenther, Christian, Gaus, Wilhelm, Hoegel, Josef

“…There is controversy as to whether haemodialysismembrane biocompatibility (ie, the potential to activate complement and neutrophils) influences mortality of…”
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