Search Results - "Wilgus, Traci A"

A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis by Wilgus, Traci A, Ud-Din, Sara, Bayat, Ardeshir

“…Scars are generated in mature skin as a result of the normal repair process, but the replacement of normal tissue with scar tissue can lead to biomechanical…”
Get full text

Macrophages in Healing Wounds: Paradoxes and Paradigms by DiPietro, Luisa A, Wilgus, Traci A, Koh, Timothy J

“…Macrophages are prominent cells in normally healing adult skin wounds, yet their exact functions and functional significance to healing outcomes remain…”
Get full text

Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models by Chesko, David M, Wilgus, Traci A

“…The healing of skin wounds involves the activation and recruitment of various immune cell types, many of which are believed to contribute significantly to…”
Get full text

Mast Cells in Skin Scarring: A Review of Animal and Human Research by Ud-Din, Sara, Wilgus, Traci A, Bayat, Ardeshir

“…Mast cells (MCs) are an important immune cell type in the skin and play an active role during wound healing. MCs produce mediators that can enhance acute…”
Get full text

Mast cell activity in the healing wound: more than meets the eye? by Wulff, Brian C., Wilgus, Traci A.

“…Mast cells (MCs) are an important part of the innate immune system and are abundant in barrier organs such as the skin. They are known primarily for initiating…”
Get full text

Blockade of mast cell activation reduces cutaneous scar formation by Chen, Lin, Schrementi, Megan E, Ranzer, Matthew J, Wilgus, Traci A, DiPietro, Luisa A

“…Damage to the skin initiates a cascade of well-orchestrated events that ultimately leads to repair of the wound. The inflammatory response is key to wound…”
Get full text

High resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics and hemodynamics under fetal, adult and diabetic conditions by Gnyawali, Surya C, Sinha, Mithun, El Masry, Mohamed S, Wulff, Brian, Ghatak, Subhadip, Soto-Gonzalez, Fidel, Wilgus, Traci A, Roy, Sashwati, Sen, Chandan K

“…Non-invasive, repeated interrogation of the same wound is necessary to understand the tissue repair continuum. In this work, we sought to test the significance…”
Get full text

Mast Cells Contribute to Scar Formation during Fetal Wound Healing by Wulff, Brian C., Parent, Allison E., Meleski, Melissa A., DiPietro, Luisa A., Schrementi, Megan E., Wilgus, Traci A.

“…Scar formation is a potentially detrimental process of tissue restoration in adults, affecting organ form and function. During fetal development, cutaneous…”
Get full text

Regulation of scar formation by vascular endothelial growth factor by Wilgus, Traci A, Ferreira, Ahalia M, Oberyszyn, Tatiana M, Bergdall, Valerie K, DiPietro, Luisa A

“…Vascular endothelial growth factor (VEGF-A) is known for its effects on endothelial cells and as a positive mediator of angiogenesis. VEGF is thought to…”
Get full text

Pre-Emptive Priming of Human Skin Improves Cutaneous Scarring and Is Superior to Immediate and Delayed Topical Anti-Scarring Treatment Post-Wounding: A Double-Blind Randomised Placebo-Controlled Clinical Trial by Ud-Din, Sara, Wilgus, Traci A, McGeorge, Douglas D, Bayat, Ardeshir

“…The concept of pre-emptive priming of skin pre-surgery offers a novel approach in optimizing cutaneous scarring outcome. We previously showed an anti-scarring…”
Get full text

Alerting the Body to Tissue Injury: The Role of Alarmins and DAMPs in Cutaneous Wound Healing by Wilgus, Traci A.

“…Purpose of Review Tissue injury stimulates an inflammatory response that is mediated in part by alarmins. Alarmins are a group of endogenous molecules that…”
Get full text

The alarmin HMGB-1 influences healing outcomes in fetal skin wounds by Dardenne, Adrienne D., Wulff, Brian C., Wilgus, Traci A.

“…In mice, cutaneous wounds generated early in development (embryonic day 15, E15) heal scarlessly, while wounds generated late in gestation (embryonic day 18,…”
Get full text

Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers by Gallego-Perez, Daniel, PhD, Otero, Jose J., MD, PhD, Czeisler, Catherine, PhD, Ma, Junyu, PhD, Ortiz, Cristina, BSc, Gygli, Patrick, PhD, Catacutan, Fay Patsy, BSc, Gokozan, Hamza Numan, MD, Cowgill, Aaron, Sherwood, Thomas, PhD, Ghatak, Subhadip, PhD, Malkoc, Veysi, PhD, Zhao, Xi, PhD, Liao, Wei-Ching, PhD, Gnyawali, Surya, PhD, Wang, Xinmei, PhD, Adler, Andrew F., PhD, Leong, Kam, PhD, Wulff, Brian, PhD, Wilgus, Traci A., PhD, Askwith, Candice, PhD, Khanna, Savita, PhD, Rink, Cameron, PhD, Sen, Chandan K., PhD, Lee, L. James, PhD

“…Abstract Safety concerns and/or the stochastic nature of current transduction approaches have hampered nuclear reprogramming's clinical translation. We report…”
Get full text

Multiple Roles for VEGF in Non-Melanoma Skin Cancer: Angiogenesis and Beyond by Johnson, Kelly E., Wilgus, Traci A.

“…Vascular endothelial growth factor (VEGF) is known to play a critical role in the development of non-melanoma skin cancers. VEGF is a potent pro-angiogenic…”
Get full text

A Murine Incisional Fetal Wound-Healing Model to Study Scarless and Fibrotic Skin Repair by Wilgus, Traci A

“…The ideal response to skin injury is the complete regeneration of normal tissue without scar formation. This regenerative response is known to occur at early…”
Get more information

New Mechanisms of ECM Production during Wound Healing: A Role for Parathyroid Hormone 2 Receptor Signaling by Wilgus, Traci A.

“…Extracellular matrix deposition is required for wound healing. Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular…”
Get full text

Importance of the EP1 Receptor in Cutaneous UVB-Induced Inflammation and Tumor Development by Tober, Kathleen L., Wilgus, Traci A., Kusewitt, Donna F., Thomas-Ahner, Jennifer M., Maruyama, Takayuki, Oberyszyn, Tatiana M.

“…Chronic exposure to UV light, the primary cause of skin cancer, results in the induction of high levels of cyclooxygenase-2 (COX-2) expression in the skin. The…”
Get full text

The Impact of Cyclooxygenase-2 Mediated Inflammation on Scarless Fetal Wound Healing by Wilgus, Traci A., Bergdall, Valerie K., Tober, Kathleen L., Hill, Kara J., Mitra, Srabani, Flavahan, Nicholas A., Oberyszyn, Tatiana M.

“…Cyclooxygenase-2 (COX-2) and the prostaglandin products generated as a result of COX-2 activity mediate a variety of biological and pathological processes…”
Get full text

Immune cells in the healing skin wound: Influential players at each stage of repair by Wilgus, Traci A.

“…Immune cells are involved in virtually every aspect of the wound repair process, from the initial stages where they participate in hemostasis and work to…”
Get full text

Reduction of scar formation in full-thickness wounds with topical celecoxib treatment by Wilgus, Traci A., Vodovotz, Yael, Vittadini, Elena, Clubbs, Elizabeth A., Oberyszyn, Tatiana M.

“…Adult wound repair occurs with an initial inflammatory response, reepithelialization, and the formation of a permanent scar. Although the inflammatory phase is…”
Get full text