Search Results - "Wiley interdisciplinary reviews. RNA"

Alternative‐splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics by Urbanski, Laura M., Leclair, Nathan, Anczuków, Olga

“…Defects in alternative splicing are frequently found in human tumors and result either from mutations in splicing‐regulatory elements of specific cancer genes…”
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Circular RNA translation, a path to hidden proteome by Sinha, Tanvi, Panigrahi, Chirag, Das, Debojyoti, Panda, Amaresh

“…Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules, constituting less than 5% of the cellular transcriptome. The majority…”
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The Ccr4-Not complex is a key regulator of eukaryotic gene expression by Collart, Martine A.

“…The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of…”
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microRNA strand selection: Unwinding the rules by Medley, Jeffrey C., Panzade, Ganesh, Zinovyeva, Anna Y.

“…microRNAs (miRNAs) play a central role in the regulation of gene expression by targeting specific mRNAs for degradation or translational repression. Each miRNA…”
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Intriguing circles: Conflicts and controversies in circular RNA research by Li, Hui‐Min, Ma, Xiu‐Lan, Li, Hong‐Gang

“…Circular RNAs (circRNAs) are covalently closed RNA circles without a 5′ cap or 3′ tail. Since the landmark discovery of ciRS‐7/CDR1as functioning as a miR‐7…”
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Hfq chaperone brings speed dating to bacterial sRNA by Santiago‐Frangos, Andrew, Woodson, Sarah A.

“…Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea. Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing…”
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Regulation of ribosomal protein genes: An ordered anarchy by Petibon, Cyrielle, Malik Ghulam, Mustafa, Catala, Mathieu, Abou Elela, Sherif

“…Ribosomal protein genes are among the most highly expressed genes in most cell types. Their products are generally essential for ribosome synthesis, which is…”
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How to get away with nonsense: Mechanisms and consequences of escape from nonsense‐mediated RNA decay by Dyle, Michael C., Kolakada, Divya, Cortazar, Michael A., Jagannathan, Sujatha

“…Nonsense‐mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control process that serves both as a mechanism to eliminate aberrant transcripts…”
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Influence of miRNA in insulin signaling pathway and insulin resistance: micro-molecules with a major role in type-2 diabetes by Chakraborty, Chiranjib, Doss, C. George Priya, Bandyopadhyay, Sanghamitra, Agoramoorthy, Govindasamy

“…The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe since the last decade. This heterogeneous and multifactorial disease,…”
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Modulating splicing with small molecular inhibitors of the spliceosome by Effenberger, Kerstin A., Urabe, Veronica K., Jurica, Melissa S.

“…Small molecule inhibitors that target components of the spliceosome have great potential as tools to probe splicing mechanism and dissect splicing regulatory…”
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Targeting RNA in mammalian systems with small molecules by Donlic, Anita, Hargrove, Amanda E.

“…The recognition of RNA functions beyond canonical protein synthesis has challenged the central dogma of molecular biology. Indeed, RNA is now known to directly…”
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Applications of the versatile CRISPR‐Cas13 RNA targeting system by Kordyś, Martyna, Sen, Raneet, Warkocki, Zbigniew

“…CRISPR‐Cas are adaptable natural prokaryotic defense systems that act against invading viruses and plasmids. Among the six currently known major CRISPR‐Cas…”
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Artificial miRNAs as therapeutic tools: Challenges and opportunities by Kotowska‐Zimmer, Anna, Pewinska, Marianna, Olejniczak, Marta

“…RNA interference (RNAi) technology has been used for almost two decades to study gene functions and in therapeutic approaches. It uses cellular machinery and…”
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Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy by Jiang, Siyu, Liu, Yi, Xu, Bilian, Zhang, Yan, Yang, Min

“…Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage degradation. In the face of global trends of population aging, OA is…”
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Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny by Morris, Christelle, Cluet, David, Ricci, Emiliano P.

“…Eukaryotic gene expression is closely regulated by translation and turnover of mRNAs. Recent advances highlight the importance of translation in the control of…”
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Biogenesis, characterization, and functions of mirtrons by Salim, Uzma, Kumar, Ashish, Kulshreshtha, Ritu, Vivekanandan, Perumal

“…MicroRNAs (miRNAs) are major post‐transcriptional regulators of gene expression. They base pair with the complementary target mRNA at the 3′UTR and modulate…”
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Viral internal ribosomal entry sites: four classes for one goal by Mailliot, Justine, Martin, Franck

“…To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell entrance. Since viral genomes do not encode any components of the…”
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Therapeutic promise of engineered nonsense suppressor tRNAs by Porter, Joseph J., Heil, Christina S., Lueck, John D.

“…Nonsense mutations change an amino acid codon to a premature termination codon (PTC) generally through a single‐nucleotide substitution. The generation of a…”
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A 360° view of circular RNAs: From biogenesis to functions by Wilusz, Jeremy E.

“…The first circular RNA (circRNA) was identified more than 40 years ago, but it was only recently appreciated that circRNAs are common outputs of many…”
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Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? by Boudreault, Simon, Roy, Patricia, Lemay, Guy, Bisaillon, Martin

“…Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will…”
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