Search Results - "Wiley, Ryan"

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer's Disease and Related Dementias and Strategic Implications for Stakeholders by El-Hayek, Youssef H, Wiley, Ryan E, Khoury, Charles P, Daya, Ritesh P, Ballard, Clive, Evans, Alison R, Karran, Michael, Molinuevo, José Luis, Norton, Matthew, Atri, Alireza

“…While it is generally understood that Alzheimer's disease (AD) and related dementias (ADRD) is one of the costliest diseases to society, there is widespread…”
Get more information

Tackling healthcare access barriers for individuals with autism from diagnosis to adulthood by Malik-Soni, Natasha, Shaker, Andrew, Luck, Helen, Mullin, Anne E., Wiley, Ryan E., Lewis, M. E. Suzanne, Fuentes, Joaquin, Frazier, Thomas W.

“…Most individuals with autism spectrum disorder (ASD)—a complex, life-long developmental disorder—do not have access to the care required to address their…”
Get full text

From the voices of people with haemophilia A and their caregivers: Challenges with current treatment, their impact on quality of life and desired improvements in future therapies by Wiley, Ryan E., Khoury, Charles P., Snihur, Adrian W. K., Williams, Marni, Page, David, Graham, Nicole, Laudenbach, Lori, Milne‐Wren, Cindy, Stoffman, Jayson M.

“…Introduction Haemophilia A is a chronic disease requiring frequent intravenous infusions of recombinant factor VIII. Previous studies have shown that…”
Get full text

Inclusion, diversity, equity, and accessibility: From organizational responsibility to leadership competency by Mullin, Anne E., Coe, Imogen R., Gooden, Everton A., Tunde-Byass, Modupe, Wiley, Ryan E.

“…An awakening to systemic anti-Black racism, anti-Indigenous racism, and harmful colonial structures in the context of a pandemic has made health inequities and…”
Get full text

A Strep A vaccine global demand and return on investment forecast to inform industry research and development prioritization by Walkinshaw, Donald R., Wright, Meghan E. E., Williams, Marni, Scarapicchia, Tanya M. F., Excler, Jean-Louis, Wiley, Ryan E., Mullin, Anne E.

“…Investment in Strep A vaccine R&D is disproportionately low relative to the large burden of Strep A diseases globally. This study presents a novel Strep A…”
Get full text

Toward Developing a Preventive MERS-CoV Vaccine-Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14-15, 2015 by Excler, Jean-Louis, Delvecchio, Christopher J, Wiley, Ryan E, Williams, Marni, Yoon, In-Kyu, Modjarrad, Kayvon, Boujelal, Mohamed, Moorthy, Vasee S, Hersi, Ahmad Salah, Kim, Jerome H

“…Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures…”
Get full text

Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling by Johnson, Jill R, Wiley, Ryan E, Fattouh, Ramzi, Swirski, Filip K, Gajewska, Beata U, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Ellis, Russ, Inman, Mark D, Jordana, Manel

“…It is now fully appreciated that asthma is a disease of a chronic nature resulting from intermittent or continued aeroallergen exposure leading to airway…”
Get full text

Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes by Johnson, Jill R, Swirski, Filip K, Gajewska, Beata U, Wiley, Ryan E, Fattouh, Ramzi, Pacitto, Stephanie R, Wong, Jonathan K, Stämpfli, Martin R, Jordana, Manel

“…Asthma is a chronic airway inflammatory disease that encompasses three cardinal processes: T helper (Th) cell type 2 (Th2)-polarized inflammation, bronchial…”
Get more information

Transient Corticosteroid Treatment Permanently Amplifies the Th2 Response in a Murine Model of Asthma by Wiley, Ryan E, Cwiartka, Monika, Alvarez, David, Mackenzie, David C, Johnson, Jill R, Goncharova, Susanna, Lundblad, Lennart, Jordana, Manel

“…Corticosteroids (CS) remain the most efficacious pharmacotherapeutic option for the management of asthma. Although the acute anti-inflammatory effects of CS…”
Get full text

Organisational best practices towards gender equality in science and medicine by Coe, Imogen R, Wiley, Ryan, Bekker, Linda-Gail

“…In August 2018, the president of the World Bank noted that “‘Human capital’—the potential of individuals—is going to be the most important long-term investment…”
Get full text

Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation by Wiley, Ryan E, Goncharova, Susanna, Shea, Theresa, Johnson, Jill R, Coyle, Anthony J, Jordana, Manel

“…Given its primary role in the execution of T cell, and especially Th2, effector activity, the inducible costimulator (ICOS)/B7-related protein (RP)-1…”
Get full text

Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway by Stampfli, Martin R, Scott Neigh, G, Wiley, Ryan E, Cwiartka, Monika, Ritz, Stacey A, Hitt, Mary M, Xing, Zhou, Jordana, Manel

“…Expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in the airway allows allergic sensitization to ovalbumin (OVA) in an experimental…”
Get full text

Cytokine therapeutics for asthma: an appraisal of current evidence and future prospects by Alvarez, D, Wiley, R E, Jordana, M

“…Although current pharmacopoeia is effective in alleviating asthma symptomatology, it is equally unable to modify the fundamental immunological basis of the…”
Get more information

Probiotics in the management and prevention of atopy by Bienenstock, John, Wiley, Ryan E, Neigh, G Scott, Waserman, Susan, Keith, Paul

“…In the last few decades, industrialized countries have witnessed a disturbing rise in the prevalence of atopy. Because this epidemiological trend has emerged…”
Get full text

GM-CSF and dendritic cells in allergic airway inflammation: basic mechanisms and prospects for therapeutic intervention by Gajewska, Beata U, Wiley, Ryan E, Jordana, Manel

“…The interaction between dendritic cells (DC) and naïve T cells is the first step in the evolution of an immune response, either tolerogenic or inflammatory…”
Get more information

GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice by Stämpfli, M R, Wiley, R E, Neigh, G S, Gajewska, B U, Lei, X F, Snider, D P, Xing, Z, Jordana, M

“…The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin (OVA) in the context of local expression of GM-CSF can initiate a…”
Get full text

Fostering Clinical Research in the Community Hospital: Opportunities and Best Practices by Snihur, Adrian, Mullin, Anne, Haller, Andrew, Wiley, Ryan, Clifford, Patrick, Roposa, Katie, MacPherson, Paul, Aasen-Johnston, Linnea

“…With potential to improve patient outcomes, quality of care and cost-effectiveness, clinical research activity in community hospitals has recently begun to…”
Get more information

Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice by Wiley, R, Palmer, K, Gajewska, B, Stämpfli, M, Alvarez, D, Coyle, A, Gutierrez-Ramos, J, Jordana, M

“…Although the preliminary characterization of chemokines and their receptors has been prolific, comparatively little is known about the role of chemokines in…”
Get full text

Investigation of immunomodulatory concepts in a murine model of airway mucosal sensitization to innocuous antigen by Wiley, Ryan E

“…The epidemic rise in the prevalence of allergy and asthma, primarily in the "developed" world, has impelled prolific nodes of inquiry into the epidemiology,…”
Get full text

Probiotics in the management and prevention of atopy: Robotics and immunity by BIENENSTOCK, John, WILEY, Ryan E, NEIGH, G. Scott, WASERMAN, Susan, KEITH, Paul

Get full text