Search Results - "Wiley, R.G."

Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat by Vierck, C.J, Yezierski, R.P, Wiley, R.G

“…Highlights • Pain sensitivity of rats was evaluated following ICV administration of 192-sap. • ICV administration of 192-sap destroyed basal forebrain…”
Get full text

Neuropeptide Y receptor-expressing dorsal horn neurons: Role in nocifensive reflex and operant responses to aversive cold after CFA inflammation by Lemons, L.L, Wiley, R.G

“…Highlights ► Intrathecal injection of NPY-sap reduced cold aversion on the thermal preference and escape tasks. ► i.t. NPY-sap was analgesic to noxious heat on…”
Get full text

Galanin receptor-expressing dorsal horn neurons: Role in nociception by Lemons, Laurie L, Wiley, R.G

“…Abstract Galanin, along with enkephalins and neuropeptide Y, has been hypothesized to negatively modulate nociception in the superficial dorsal horn of the…”
Get full text

Neuropeptide Y receptor-expressing dorsal horn neurons: Role in nocifensive reflex responses to heat and formalin by Wiley, R.G, Lemons, L.L, Kline, R.H

“…Abstract Lumbar intrathecal injection of neuropeptide Y (NPY) is antinociceptive, particularly in models of nerve injury and inflammation. Intrathecal NPY does…”
Get full text

Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9 ,Met(O2 )11 ]-substance P-saporin: Behavioral and anatomical analyses by Wiley, R.G, Kline, R.H, Vierck, C.J

“…Abstract Lumbar intrathecal injections of substance P-saporin (SP-sap) destroy dorsal horn neurons that express the neurokinin-1 receptor (NK-1R) resulting in…”
Get full text

Hippocampal theta activity following selective lesion of the septal cholinergic system by Lee, M G, Chrobak, J J, Sik, A, Wiley, R G, Buzsáki, G

“…The characteristic electroencephalographic patterns within the hippocampus are theta and sharp waves. Septal neurons are believed to play an essential role in…”
Get more information

Intrathecal substance p–saporin attenuates operant escape from nociceptive thermal stimuli by Vierck, C.J., Kline, R.H., Wiley, R.G.

“…Destruction of neurons in the superficial dorsal horn that express substance P receptor (NK-1R) has been reported to block development of behavioral…”
Get full text

192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells by Waite, J.J., Chen, A.D., Wardlow, M.L., Wiley, R.G., Lappi, D.A., Thal, L.J.

“…Immunolesions of the cholinergic basal forebrain were produced in rats using various intraventricular doses of the immunotoxin 192 immunoglobulin G-saporin:…”
Get full text

Retrograde degeneration and colchicine protection of basal forebrain cholinergic neurons following hippocampal injections of an immunotoxin against the p75 nerve growth factor receptor by Ohtake, T, Heckers, S, Wiley, R.G, Lappi, D.A, Mesulam, M.-M, Geula, C

“…Intracerebroventricular injection of 192 IgG antibody against the p75 LNGFR rat low affinity nerve growth factor receptor conjugated with saporin, a ribosome…”
Get full text

Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system by Torres, E M, Perry, T A, Blockland, A, Wilkinson, L S, Wiley, R G, Lappi, D A, Dunnet, S B

“…The effectiveness of a recently developed immunotoxin, 192 IgG-saporin, was evaluated for making selective lesions of subgroups of basal forebrain cholinergic…”
Get more information

Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits by Walsh, T.J., Herzog, C.D., Gandhi, C., Stackman, R.W., Wiley, R.G.

“…192-IgG saporin is an anti-neuronal immunotoxin that combines the 192 monoclonal antibody to the p75 neurotrophin receptor found on terminals and cell bodies…”
Get full text

Targeting neurokinin-1 receptor-expressing neurons with [Sar 9,Met(O 2) 11]substance P-saporin by Wiley, R.G, Lappi, D.A

“…Neurons expressing neurokinin-1 receptors (NK-1R) are selectively destroyed by substance P (SP) coupled to the ribosome inactivating protein, saporin…”
Get full text

Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats by Wiley, R.G, Lappi, D.A

“…Substance P (SP) acts on neurons through the neurokinin-1 (NK-1) receptor. Conjugation of SP to the ribosome inactivating protein, saporin (SAP), produces a…”
Get full text

Lack of effect of moderate Purkinje cell loss on working memory by Wrenn, C.C, Wiley, R.G

“…192 immunoglobulin G-saporin (192-sap) is an immunotoxin which targets the cholinergic basal forebrain after injection into either the ventricular system or…”
Get full text

Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: Role of the septohippocampal projection by Steckler, T., Keith, A.B., Wiley, R.G., Sahgal, A.

“…Two experiments examined the effects of cholinergic basal forebrain lesions by intraventricular and intrahippocampal infusions of the immunotoxin 192…”
Get full text

Effects of neonatal lesions on the basal forebrain cholinergic system by 192 Immunoglobulin G-saporin : Biochemical, behavioural and morphological characterization by LEANZA, G, NILSSON, O. G, NIKKHAH, G, WILEY, R. G, BJÖRKLUND, A

“…Selective removal of the basal forebrain cholinergic neurons by the immunotoxin 192 immunoglobulin G-saporin has offered a new powerful tool for the study of…”
Get full text

Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin: cholinergic and non-cholinergic effects following i.c.v. injection by Walsh, T.J., Kelly, R.M., Dougherty, K.D., Stackman, R.W., Wiley, R.G., Kutscher, C.L.

“…192-IgG-Saporin is an anti-neuronal immunotoxin that combines the 192 monoclonal antibody to the p75 neurotrophin receptor found on terminals and cell bodies…”
Get full text

Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation by Kokaia, M., Ferencz, I., Leanza, G., Elmér, E., Metsis, M., Kokaia, Z., Wiley, R.G., Lindvall, O.

“…The immunotoxin 192 IgG-saporin induces an efficient and specific lesion of low-affinity nerve growth factor receptor-bearing cholinergic neurons in the basal…”
Get full text

Destruction of locus coeruleus neuronal perikarya after injection of anti-dopamine-B-hydroxylase immunotoxin into the olfactory bulb of the rat by Blessing, W.W, Lappi, D.A, Wiley, R.G

“…Saporin, a ribosome-inactivating protein, was coupled to a monoclonal antibody to dopamine-B-hydroxylase (DBH) and injected unilaterally into the olfactory…”
Get full text

Altered NGF protein levels in different brain areas after immunolesion by Yu, J., Wiley, R.G., Perez-Polo, R.J.

“…Nerve growth factor (NGF) provides critical trophic support to the cholinergic basal forebrain neurons that express high levels of the low‐affinity NGF…”
Get full text