Search Results - "Wiley, John W."

Chronic stress and intestinal permeability: Lubiprostone regulates glucocorticoid receptor‐mediated changes in colon epithelial tight junction proteins, barrier function, and visceral pain in the rodent and human by Zong, Ye, Zhu, Shengtao, Zhang, Shutian, Zheng, Gen, Wiley, John W, Hong, Shuangsong

“…Background Chronic psychological stress is associated with increased intestinal epithelial permeability and visceral hyperalgesia. Lubiprostone, an agonist for…”
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Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways by Zheng, Gen, Hong, Shuangsong, Hayes, John M., Wiley, John W.

“…Chronic stress alters the hypothalamic–pituitary–adrenal (HPA) axis and enhances visceral and somatosensory pain perception. It is unresolved whether chronic…”
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The emerging role of autophagy in the pathophysiology of diabetes mellitus by Gonzalez, Claudio D., Lee, Myung-Shik, Marchetti, Piero, Pietropaolo, Massimo, Towns, Roberto, Vaccaro, Maria I., Watada, Hirotaka, Wiley, John W.

“…An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of…”
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Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research by Chang, Lin, Di Lorenzo, Carlo, Farrugia, Gianrico, Hamilton, Frank A., Mawe, Gary M., Pasricha, Pankaj J., Wiley, John W.

“…In June 2016, the National Institutes of Health hosted a workshop on functional bowel disorders (FBDs), particularly irritable bowel syndrome, with the…”
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Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter by Zheng, Gen, Victor Fon, Gordon, Meixner, Walter, Creekmore, Amy, Zong, Ye, K. Dame, Michael, Colacino, Justin, Dedhia, Priya H., Hong, Shuangsong, Wiley, John W.

“…Chronic stress and elevated glucocorticoid hormone are associated with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1)…”
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Chronic psychological stress alters gene expression in rat colon epithelial cells promoting chromatin remodeling, barrier dysfunction and inflammation by Wiley, John W, Higgins, Gerald A, Hong, Shuangsong

“…Chronic stress is commonly associated with enhanced abdominal pain (visceral hypersensitivity), but the cellular mechanisms underlying how chronic stress…”
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Corticosterone Mediates Reciprocal Changes in CB 1 and TRPV1 Receptors in Primary Sensory Neurons in the Chronically Stressed Rat by Hong, Shuangsong, Zheng, Gen, Wu, Xiaoyin, Snider, Natasha T, Owyang, Chung, Wiley, John W

“…Background & Aims Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone…”
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Comparisons of different electrical stimulation modalities for treating visceral pain in a rodent model of irritable bowel syndrome by Alam, Md Jahangir, Zhao, Tingting, Wiley, John W., Chen, Jiande D. Z.

“…Abstract The purpose of this study was to investigate the effects of different electrical stimulation methods (bilateral electroacupuncture (BEA), unilateral…”
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Early Painful Diabetic Neuropathy Is Associated with Differential Changes in the Expression and Function of Vanilloid Receptor 1 by Hong, Shuangsong, Wiley, John W.

“…Diabetes mellitus is associated with one or more kinds of stimulus-evoked pain including hyperalgesia and allodynia. The mechanisms underlying painful diabetic…”
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Epigenetic Regulation of Genes That Modulate Chronic Stress-Induced Visceral Pain in the Peripheral Nervous System by Hong, Shuangsong, Zheng, Gen, Wiley, John W

“…Background & Aims Chronic stress alters the hypothalamic–pituitary–adrenal axis, increases gut motility, and increases the perception of visceral pain. We…”
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The Role of the Endocannabinoid System in the Brain–Gut Axis by Sharkey, Keith A., Wiley, John W.

“…The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system (ECS) consists of the naturally…”
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Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome by Zheng, Gen, Pang, Suya, Wang, Junbao, Wang, Fangyu, Wang, Qi, Yang, Lili, Ji, Mengdie, Xie, Dejian, Zhu, Shengtao, Chen, Yang, Zhou, Yan, Higgins, Gerald A., Wiley, John W., Hou, Xiaohua, Lin, Rong

“…Stress-elevated glucocorticoids cause circadian disturbances and gut-brain axis (GBA) disorders, including irritable bowel syndrome (IBS). We hypothesized that…”
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Structural and functional alterations in the colonic microbiome of the rat in a model of stress induced irritable bowel syndrome by Fourie, Nicolaas H., Wang, Dan, Abey, Sarah K., Creekmore, Amy L., Hong, Shuangsong, Martin, Christiana G., Wiley, John W., Henderson, Wendy A.

“…Stress is known to perturb the microbiome and exacerbate irritable bowel syndrome (IBS) associated symptoms. Characterizing structural and functional changes…”
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Early Painful Diabetic Neuropathy Is Associated with Differential Changes in Tetrodotoxin-sensitive and -resistant Sodium Channels in Dorsal Root Ganglion Neurons in the Rat by Hong, Shuangsong, Morrow, Thomas J, Paulson, Pamela E, Isom, Lori L, Wiley, John W

“…Diabetic neuropathy is a common form of peripheral neuropathy, yet the mechanisms responsible for pain in this disease are poorly understood. Alterations in…”
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Functional Bowel Disorders by Wiley, John W., Chang, Lin

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Altered expression and function of sodium channels in large DRG neurons and myelinated A-fibers in early diabetic neuropathy in the rat by Hong, Shuangsong, Wiley, John W.

“…Differential alterations of sodium channels in small nociceptive C-fiber DRG neurons have been implicated in diabetic neuropathy. In this study, we…”
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Histone H3K9 methylation regulates chronic stress and IL‐6–induced colon epithelial permeability and visceral pain by Wiley, John W., Zong, Ye, Zheng, Gen, Zhu, Shengtao, Hong, Shuangsong

“…Background Chronic stress is associated with activation of the HPA axis, elevation in pro‐inflammatory cytokines, decrease in intestinal epithelial cell tight…”
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2015 James W. Freston Single Topic Conference: A Renaissance in the Understanding and Management of Irritable Bowel Syndrome by Chang, Lin, Heitkemper, Margaret M, Wiley, John W, Camilleri, Michael

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The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia by Higgins, Gerald A., Hong, Shaungsong, Wiley, John W.

“…The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS)…”
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Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction by Creekmore, Amy L., Hong, Shuangsong, Zhu, Shengtao, Xue, Jing, Wiley, John W.

“…In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in…”
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