Search Results - "Wiley, J N"

The pharmacology of the novel and selective sigma ligand, PD 144418 by AKUNNE, H. C, WHETZEL, S. Z, WILEY, J. N, CORBIN, A. E, NINTEMAN, F. W, TECLE, H, PEI, Y, PUGSLEY, T. A, HEFFNER, T. G

“…The pharmacology of PD 144418 (1-propyl-5-(3-p-tolyl-isoxazol-5-yl)-1,2,3,6-tetrahydropyridine) was characterized using neurochemical, biochemical and…”
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CI-1007, a dopamine partial agonist and potential antipsychotic agent. II. Neurophysiological and behavioral effects by Meltzer, L T, Christoffersen, C L, Corbin, A E, Ninteman, F W, Serpa, K A, Wiley, J N, Wise, L D, Heffner, T G

“…CI-1007 has been described in receptor binding and biochemical tests as a dopamine (DA) partial agonist that exhibits DA autoreceptor agonist effects. The…”
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Pharmacological characterization of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist by Pugsley, T A, Christofferson, C L, Corbin, A, DeWald, H A, Demattos, S, Meltzer, L T, Myers, S L, Shih, Y H, Whetzel, S Z, Wiley, J N

“…PD 118717 (7-[3-[4-(2-pyrimidinyl)-1-piperazinyl]-propoxy]-2H-1- benzopyran-2-one sulfate) proved to be a dopamine (DA) D-2 autoreceptor agonist in biochemical…”
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Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice by HEFFNER, T. G, WILEY, J. N, WILLIAMS, A. E, BRUNS, R. F, COUGHENOUR, L. L, DOWNS, D. A

“…The adenosine agonists 5'-N-ethylcarboxamideadenosine (NECA), 2-chloroadenosine (2-CLA), N6-cyclohexyladenosine (CHA), N6-cyclopentyladenosine (CPA),…”
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Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys by Reuning, R H, Ashcraft, S B, Wiley, J N, Morrison, B E

“…The purposes of this investigation were to determine the disposition of naltrexone (NTX) in monkeys and assess the role of first-pass metabolism and…”
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Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists by Pugsley, T.A., Akunne, H.C., Whetzel, S.Z., Demattos, S., Corbin, A.E., Wiley, J.N., Wustrow, D.J., Wise, L.D., Heffner, T.G.

“…In in vitro studies, SR 48692, a nonpeptide neurotensin receptor antagonist, inhibited the binding of [ 3H] or [ 125I]neurotensin to membrane preparations from…”
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CI-943, a potential antipsychotic agent. I. Preclinical behavioral effects by Heffner, T G, Downs, D A, Meltzer, L T, Wiley, J N, Williams, A E

“…CI-943 (8-ethyl-7,8-dihydro-1,3,5-trimethyl-1H-imidazo[1,2-c] pyrazolo[3,4-e]-pyrimidine) is a novel agent that is chemically unrelated to available…”
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Contractile force transducer for recording muscle activity in unanesthetized animals by Bass, P, Wiley, J N

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Pharmacokinetics and pharmacodynamics of an investigational antipsychotic agent, CI-1007, in rats and monkeys by FENG, M. R, CORBIN, A. E, WRIGHT, D. S, WANG, Y, CHRISTOFFERSEN, C. L, WILEY, J. N, STRENKOSKI, C. A, TUCKER, E. V, NINTEMAN, F. W, MELTZER, L. T, HEFFNER, T. G

“…To study the pharmacokinetics (PK) and pharmacodynamics (PD) of an investigational antipsychotic agent, CI-1007, in rats and monkeys. CI-1007 and a…”
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Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents by Sebolt-Leopold, J S, Vincent, P W, Beningo, K A, Elliott, W L, Leopold, W R, Heffner, T G, Wiley, J N, Stier, M A, Suto, M J

“…RB 6145, the ring-opened analog of RSU 1069, and PD 130908, the desoxy ring-opened analog of RSU 1069, were compared to RSU 1069 for their emetic potential in…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT(1A) agonist actions. II. Preclinical behavioral effects by Corbin, A E, Meltzer, L T, Ninteman, F W, Wiley, J N, Christoffersen, C L, Wustrow, D J, Wise, L D, Pugsley, T A, Heffner, T G

“…PD 158771 has been described in receptor binding and biochemical tests as a partial agonist at dopamine (DA) D2 and D3 receptors as well as an agonist at…”
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Evidence for postsynaptic dopamine agonist effects of B-HT 920 in the presence of the dopamine D-1 agonist SKF 38393 by MELTZER, L. T, WILEY, J. N, WILLIAMS, A. E, HEFFNER, T. G

“…The ability of B-HT 920, a selective dopamine (DA) D-2 agonist, to stimulate postsynaptic DA receptors in brain was evaluated by assessing its ability to…”
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Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers by Meltzer, L T, Caprathe, B W, Christoffersen, C L, Corbin, A E, Jaen, J C, Ninteman, F W, Pugsley, T A, Serpa, K A, Shih, Y H, Whetzel, S Z

“…(+/-)-PD 128483, ((+/-)-4,5,5a,6,7,8-hexahydro-6-methylthiazolo[4,5-f]-quinolin+ ++-2-amine, maleate (1:1)), is a racemic compound that is a p.o. active…”
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Anti-writhing activity of some peptides related to neurotensin and tuftsin by Nicolaides, E D, Lunney, E A, Kaltenbronn, J S, Wiley, J N, Downs, D A

“…Several small peptides related to neurotensin (NT) and tuftsin were synthesized and tested for analgesic activity against acetic acid induced writhing in mice…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. II. Preclinical behavioral effects by CORBIN, A. E, MELTZER, L. T, NINTEMAN, F. W, WILEY, J. N, CHRISTOFFERSEN, C. L, WUSTROW, D. J, WISE, L. D, PUGSLEY, T. A, HEFFNER, T. G

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Reduced amide bond neurotensin 8–13 mimetics with potent in vivo activity by Wustrow, D.J., Davis, M.D., Akunne, H.C., Corbin, A.E., Wiley, J.N., Wise, L.D., Heffner, T.G.

“…Appropriately substituted 8–9 (ΨCH 2NH) isosteres of neurotensin (NT) 8–13 have been found which are active as NT agonists in vitro and in vivo. SAR studies…”
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Pharmacokinetic quantitation of naltrexone controlled release from a copolymer delivery system by Reuning, R H, Liao, S H, Staubus, A E, Ashcraft, S B, Downs, D A, Harrigan, S E, Wiley, J N, Wise, D L

“…Naltrexone release rates from a controlled release delivery system have been quantitated over a time period greater than one month in the monkey. The method…”
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Prolonged Administration of Atropine or Histamine in a Silicone Rubber Implant by BASS, PAUL, PURDON, R. A, WILEY, J. N

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CI-750, A novel antidiarrheal agent by Bass, P, Kennedy, J A, Wiley, J N, Villarreal, J, Butler, D E

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Contractile activity of gastric antrum and taenia coli in the unanesthetized monkey by Weisbrodt, N W, Hug, Jr, C C, Wiley, J N, Bass, P

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