Search Results - "Wiley, Christopher D."

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence by Wiley, Christopher D., Campisi, Judith

“…Cellular senescence is a complex stress response that permanently arrests the proliferation of cells at risk for oncogenic transformation. However, senescent…”
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The metabolic roots of senescence: mechanisms and opportunities for intervention by Wiley, Christopher D., Campisi, Judith

“…Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous…”
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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging by Ziegler, Dorian V., Wiley, Christopher D., Velarde, Michael C.

“…Summary Cellular senescence is a process that results from a variety of stresses, leading to a state of irreversible growth arrest. Senescent cells accumulate…”
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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype by Wiley, Christopher D., Velarde, Michael C., Lecot, Pacome, Liu, Su, Sarnoski, Ethan A., Freund, Adam, Shirakawa, Kotaro, Lim, Hyung W., Davis, Sonnet S., Ramanathan, Arvind, Gerencser, Akos A., Verdin, Eric, Campisi, Judith

“…Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of…”
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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice by Asadi Shahmirzadi, Azar, Edgar, Daniel, Liao, Chen-Yu, Hsu, Yueh-Mei, Lucanic, Mark, Asadi Shahmirzadi, Arash, Wiley, Christopher D., Gan, Garbo, Kim, Dong Eun, Kasler, Herbert G., Kuehnemann, Chisaka, Kaplowitz, Brian, Bhaumik, Dipa, Riley, Rebeccah R., Kennedy, Brian K., Lithgow, Gordon J.

“…Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting,…”
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Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence by Wiley, Christopher D., Flynn, James M., Morrissey, Christapher, Lebofsky, Ronald, Shuga, Joe, Dong, Xiao, Unger, Marc A., Vijg, Jan, Melov, Simon, Campisi, Judith

“…Summary Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent…”
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Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis by Wiley, Christopher D., Sharma, Rishi, Davis, Sonnet S., Lopez-Dominguez, Jose Alberto, Mitchell, Kylie P., Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew, Aimontche, Eliezer, Deshpande, Sharvari M., Neri, Francesco, Kuehnemann, Chisaka, Demaria, Marco, Ramanathan, Arvind, Campisi, Judith

“…Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological…”
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Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal by Kuehnemann, Chisaka, Hughes, Jun‐Wei B., Desprez, Pierre‐Yves, Melov, Simon, Wiley, Christopher D., Campisi, Judith

“…Antiretroviral drugs have dramatically improved the prognosis of HIV‐infected patients, with strikingly reduced morbidity and mortality. However, long‐term use…”
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Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype by Wiley, Christopher D., Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V., Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R., Campisi, Judith

“…Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide,…”
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SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells by Wiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka, Danielson, Steven R., Basisty, Natan, Kasler, Herbert G., Oron, Tal Ronnen, Desprez, Pierre-Yves, Mooney, Sean D., Gibson, Bradford W., Schilling, Birgit, Campisi, Judith, Kapahi, Pankaj

“…Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that…”
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Melanism in peromyscus is caused by independent mutations in agouti by Kingsley, Evan P, Manceau, Marie, Wiley, Christopher D, Hoekstra, Hopi E

“…Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence…”
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Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases by Faggioli, Francesca, Velarde, Michael C, Wiley, Christopher D

“…Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn…”
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Mitochondria-Targeted Catalase Does Not Suppress Development of Cellular Senescence during Aging by Mogck, Bronwyn A, Jezak, Samantha T, Wiley, Christopher D

“…Cellular senescence is a complex stress response marked by stable proliferative arrest and the secretion of biologically active molecules collectively known as…”
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Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype by Kuehnemann, Chisaka, Hu, Kang-Quan, Butera, Kayla, Patel, Sandip K, Bons, Joanna, Schilling, Birgit, Aguayo-Mazzucato, Cristina, Wiley, Christopher D

“…Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a…”
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Bubble Bubble, Senescent Cells Are a Cauldron of Tumor Trouble by Wiley, Christopher D

“…Senescent cells release a mélange of factors that drive multiple forms of pathology, including cancer aggressiveness. In this issue of , Han and colleagues…”
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Senescent cells at the crossroads of aging, disease, and tissue homeostasis by Kuehnemann, Chisaka, Wiley, Christopher D.

“…Originally identified as an outcome of continuous culture of primary cells, cellular senescence has moved beyond the culture dish and is now a bona fide driver…”
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Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease by Wiley, Christopher D.

“…Purpose of Review Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure…”
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Rate-Limiting Enzymes in Cardiometabolic Health and Aging in Humans by Parnell, Laurence D., McCaffrey, Kira S., Brooks, Athena W., Smith, Caren E., Lai, Chao-Qiang, Christensen, Jacob J., Wiley, Christopher D., Ordovas, Jose M.

“…Introduction: Rate-limiting enzymes (RLEs) are innate slow points in metabolic pathways, and many function in bio-processes related to nutrient sensing. Many…”
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis by Wiley, Christopher D., Brumwell, Alexis N., Davis, Sonnet S., Jackson, Julia R., Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A., Ruan, Richard, Wei, Ying, Chapman, Harold A., Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude

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Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling by Alimirah, Fatouma, Pulido, Tanya, Valdovinos, Alexis, Alptekin, Sena, Chang, Emily, Jones, Elijah, Diaz, Diego A, Flores, Jose, Velarde, Michael C, Demaria, Marco, Davalos, Albert R, Wiley, Christopher D, Limbad, Chandani, Desprez, Pierre-Yves, Campisi, Judith

“…Cellular senescence entails an irreversible growth arrest that evolved in part to prevent cancer. Paradoxically, senescent cells secrete proinflammatory and…”
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