Search Results - "Wiles, C."

Safety and Efficacy of Vedolizumab Versus Tumor Necrosis Factor α Antagonists in an Elderly IBD Population: A Single Institution Retrospective Experience by Pabla, Baldeep S., Alex Wiles, C., Slaughter, James C., Scoville, Elizabeth A., Dalal, Robin L., Beaulieu, Dawn B., Schwartz, David A., Horst, Sara N.

“…Background Vedolizumab is a monoclonal antibody used to treat inflammatory bowel disease (IBD). There is little known about the safety and comparative efficacy…”
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A 420‐Year Perspective on Winter Lake Erie Levels by Wiles, G. C., Devereux, K., Gaglioti, B. V., D’Arrigo, R. D.

“…Here, we present a 420‐year‐long winter lake level reconstruction for Lake Erie based primarily on temperature‐sensitive tree‐ring chronologies from Alaska,…”
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Forest‐Wide Growth Rates Stabilize After Experiencing Accelerated Temperature Changes Near an Alaskan Glacier by Gaglioti, B. V., Mann, D. H., Wiles, G. C., Andreu‐Hayles, L., Hansen, W. D., Wiesenberg, N.

“…How forests respond to accelerated climate change will affect the terrestrial carbon cycle. To better understand these responses, more examples are needed to…”
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Mobility and falls in people with Huntington's disease by Busse, M E, Wiles, C M, Rosser, A E

“…Objective: The aim of this study was to estimate the frequency of falls in people with Huntington's disease (HD) and make a preliminary assessment of tools…”
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Neutrophil‐to‐lymphocyte ratio decreases after treatment of psoriasis with therapeutic antibodies by Zhang, L., Wiles, C., Martinez, L.R., Han, G.

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The significance of glucocorticoid pulsatility by Lightman, Stafford L., Wiles, Crispin C., Atkinson, Helen C., Henley, David E., Russell, Georgina M., Leendertz, Jack A., McKenna, Mervyn A., Spiga, Francesca, Wood, Susan A., Conway-Campbell, Becky L.

“…Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately…”
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Quantified measurement of activity provides insight into motor function and recovery in neurological disease by Busse, M E, Pearson, O R, Van Deursen, R, Wiles, C M

“…Background: A direct quantitative measurement of locomotor activity in an individual’s own environment over an extended period may help in evaluating the…”
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A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging by Stavri, Richard, Tay, Tabitha, Wiles, Crispin C, Di Federico, Erica, Boughton, Oliver, Ma, Shaocheng, Karunaratne, Angelo, Churchwell, John H, Bhattacharya, Rajarshi, Terrill, Nicholas J, Cobb, Justin P, Hansen, Ulrich, Abel, Richard L

“…Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level…”
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Controlled randomised crossover trial of the effects of physiotherapy on mobility in chronic multiple sclerosis by Wiles, C M, Newcombe, R G, Fuller, K J, Shaw, S, Furnival-Doran, J, Pickersgill, T P, Morgan, A

“…OBJECTIVES To determine whether physiotherapy can improve mobility in chronic multiple sclerosis and whether there is a difference between treatment at home…”
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Physiotherapy and related activities in multiple sclerosis by Wiles, CM

“…There are now about 50 randomized controlled trials into rehabilitation packages, physiotherapy or related specific and non-specific techniques in multiple…”
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Falls and stumbles in myotonic dystrophy by Wiles, C M, Busse, M E, Sampson, C M, Rogers, M T, Fenton-May, J, van Deursen, R

“…Objective: To investigate falls and risk factors in patients with myotonic dystrophy type 1 (DM1) compared with healthy volunteers. Methods: 13 sequential…”
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Quantification of walking mobility in neurological disorders by Pearson, O.R., Busse, M.E., van Deursen, R.W.M., Wiles, C.M.

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The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density by Jin, A, Cobb, J, Hansen, U, Bhattacharya, R, Reinhard, C, Vo, N, Atwood, R, Li, J, Karunaratne, A, Wiles, C, Abel, R

“…Bisphosphonates (BP) are the first-line treatment for preventing fragility fractures. However, concern regarding their efficacy is growing because…”
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Proteasome-Dependent Down-Regulation of Activated Nuclear Hippocampal Glucocorticoid Receptors Determines Dynamic Responses to Corticosterone by Conway-Campbell, Becky L, McKenna, Mervyn A, Wiles, Crispin C, Atkinson, Helen C, de Kloet, E. Ron, Lightman, Stafford L

“…Timing is a critical factor in neuroendocrinology. Despite this, the temporal aspects of glucocorticoid signaling in the regulation of in vivo targets have…”
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Divergent tree growth response to recent climatic warming, Lake Clark National Park and Preserve, Alaska by Driscoll, William W., Wiles, Gregory C., D'Arrigo, Rosanne D., Wilmking, Martin

“…Many dendroclimatic studies have been conducted in Alaska to understand recent climate changes, identify past and current warming trends, and determine how…”
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Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix by Aggleton, J. P., McMackin, D., Carpenter, K., Hornak, J., Kapur, N., Halpin, S., Wiles, C. M., Kamel, H., Brennan, P., Carton, S., Gaffan, D.

“…A series of twelve cases, all of whom had received surgery for the removal of a colloid cyst in the third ventricle, was examined on a series of memory tests…”
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Late-Glacial and Holocene Lake-Level Fluctuations on the Kenai Lowland, Reconstructed from Satellite-Fen Peat Deposits and Ice-Shoved Ramparts, Kenai Peninsula, Alaska by Berg, Edward E., Kaufman, Darrell S., Anderson, R. Scott, Wiles, Gregory C., Lowell, Thomas V., Mitchell, Edward A. D., Hu, Feng Sheng, Werner, Alan

“…Recent decades of warmer climate have brought drying wetlands and falling lake levels to southern Alaska. These recent changes can be placed into a longer-term…”
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Century to millennial-scale temperature variations for the last two thousand years indicated from glacial geologic records of Southern Alaska by Wiles, Gregory C., Barclay, David J., Calkin, Parker E., Lowell, Thomas V.

“…Comparisons of temperature sensitive climate proxy records with tree-ring, lichen and radiocarbon dated histories from land-terminating, non-surging glaciers…”
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Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor by Atkinson, Helen C, Wood, Susan A, Castrique, Emma S, Kershaw, Yvonne M, Wiles, Crispin C R, Lightman, Stafford L

“…The aim of this study was to investigate fast corticosteroid feedback of the hypothalamic-pituitary-adrenal (HPA) axis under basal conditions, in particular…”
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Population based study of late onset cerebellar ataxia in south east Wales by Muzaimi, M B, Thomas, J, Palmer-Smith, S, Rosser, L, Harper, P S, Wiles, C M, Ravine, D, Robertson, N P

“…Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based…”
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