Spindle-cell variant of ameloblastic carcinoma: a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression

Spindle-cell variant of ameloblastic carcinoma: a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression

Ameloblastic carcinoma is a rare odontogenic neoplasm that demonstrates the histologic characteristics of ameloblastoma, accompanied by the cytologic features of malignancy. The spindle-cell variant of ameloblastic carcinoma (SCAC) is exceptionally rare, with a total of 10 cases having been reported...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology and oral radiology Vol. 128; no. 3; pp. e113 - e121
Main Authors: McLean-Holden, Anne C., Bishop, Justin A., Kessler, Harvey P., Myers, Larry L., Radwan, Alaaaldin M., Wildey, Tyler C., Wright, John M., Cheng, Yi-Shing Lisa
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-09-2019
Subjects:
Adult
Ameloblastoma
Dentistry
Disease Progression
Epithelial-Mesenchymal Transition
Humans
Mandibular Neoplasms
Odontogenic Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ameloblastic carcinoma is a rare odontogenic neoplasm that demonstrates the histologic characteristics of ameloblastoma, accompanied by the cytologic features of malignancy. The spindle-cell variant of ameloblastic carcinoma (SCAC) is exceptionally rare, with a total of 10 cases having been reported in the literature to date. Histologically, a prominent sarcomatoid cell population appears to originate from the epithelial (ameloblastic) component. Like conventional ameloblastic carcinoma, most cases of SCAC occur in individuals older than 40 years of age. Here, 3 additional cases of SCAC are reported, 2 of which occurred in young individuals. Diagnostic criteria to aid in the identification of SCAC are proposed. Finally, histologic and immunohistochemical evidence supporting the occurrence of epithelial–mesenchymal transition in SCAC is presented.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2019.01.071