Search Results - "Wilderman, Scott J."

DblurDoseNet: A deep residual learning network for voxel radionuclide dosimetry compensating for single‐photon emission computerized tomography imaging resolution by Li, Zongyu, Fessler, Jeffrey A., Mikell, Justin K., Wilderman, Scott J., Dewaraja, Yuni K.

“…Purpose Current methods for patient‐specific voxel‐level dosimetry in radionuclide therapy suffer from a trade‐off between accuracy and computational…”
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Experimental validation of Monte Carlo dosimetry for therapeutic beta emitters with radiochromic film in a 3D‐printed phantom by Van, Benjamin, Dewaraja, Yuni K., Niedbala, Jeremy T., Rosebush, Gerrid, Kazmierski, Matthew, Hubers, David, Mikell, Justin K., Wilderman, Scott J.

“…Purpose Validation of dosimetry software, such as Monte Carlo (MC) radiation transport codes used for patient‐specific absorbed dose estimation, is critical…”
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Technical note: Impact of dose voxel kernel (DVK) values on dosimetry estimates in 177Lu and 90Y radiopharmaceutical therapy (RPT) applications by Danieli, Rachele, Pistone, Daniele, Tranel, Jonathan, Botta, Francesca, Uribe‐Munoz, Carlos, Raspanti, Davide, Salvat, Francesc, Wilderman, Scott J, Bardiès, Manuel, Amato, Ernesto, Dewaraja, Yuni K, Cremonesi, Marta

“…Background Radiopharmaceutical therapy (RPT) is an increasingly adopted modality for treating cancer. There is evidence that the optimization of the treatment…”
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A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177Lu-Peptide Receptor Radionuclide Therapy by Dewaraja, Yuni K, Mirando, David M, Peterson, Avery B, Niedbala, Jeremy, Millet, John D, Mikell, Justin K, Frey, Kirk A, Wong, Ka Kit, Wilderman, Scott J, Nelson, Aaron S

“…Patient-specific dosimetry in radiopharmaceutical therapy (RPT) is impeded by the lack of tools that are accurate and practical for the clinic. Our aims were…”
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Use of integrated SPECT/CT imaging for tumor dosimetry in I-131 radioimmunotherapy: a pilot patient study by Dewaraja, Yuni K, Wilderman, Scott J, Koral, Kenneth F, Kaminski, Mark S, Avram, Anca M

“…Integrated systems combining functional (single-photon emission computed tomography; SPECT) imaging with anatomic (computed tomography; CT) imaging have the…”
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Y-90 SPECT ML image reconstruction with a new model for tissue-dependent bremsstrahlung production using CT information: a proof-of-concept study by Lim, Hongki, Fessler, Jeffrey A, Wilderman, Scott J, Brooks, Allen F, Dewaraja, Yuni K

“…While the yield of positrons used in Y-90 PET is independent of tissue media, Y-90 SPECT imaging is complicated by the tissue dependence of bremsstrahlung…”
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Tumor-Absorbed Dose Predicts Progression-Free Survival Following (131)I-Tositumomab Radioimmunotherapy by Dewaraja, Yuni K, Schipper, Matthew J, Shen, Jincheng, Smith, Lauren B, Murgic, Jure, Savas, Hatice, Youssef, Ehab, Regan, Denise, Wilderman, Scott J, Roberson, Peter L, Kaminski, Mark S, Avram, Anca M

“…The study aimed at identifying patient-specific dosimetric and nondosimetric factors predicting outcome of non-Hodgkin lymphoma patients after…”
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Comparison of I-131 radioimmunotherapy tumor dosimetry: unit density sphere model versus patient-specific Monte Carlo calculations by Howard, David M, Kearfott, Kimberlee J, Wilderman, Scott J, Dewaraja, Yuni K

“…High computational requirements restrict the use of Monte Carlo algorithms for dose estimation in a clinical setting, despite the fact that they are considered…”
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Methodology to incorporate biologically effective dose and equivalent uniform dose in patient-specific 3-dimensional dosimetry for non-Hodgkin lymphoma patients targeted with 131I-tositumomab therapy by Amro, Hanan, Wilderman, Scott J, Dewaraja, Yuni K, Roberson, Peter L

“…A 3-dimensional (3D) imaging-based patient-specific dosimetry methodology incorporating antitumor biologic effects using biologically effective dose (BED) and…”
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Biological-effect modeling of radioimmunotherapy for non-hodgkins lymphoma: determination of model parameters by Roberson, Peter L, Wilderman, Scott J, Avram, Anca M, Kaminski, Mark S, Schipper, Matthew J, Dewaraja, Yuni K

“…Treatment with Tositumomab and 131I tositumomab anti-CD20 radioimmunotherapy (Bexxar) yields a nonradioactive antibody antitumor response (the so-called cold…”
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Bio-effect model applied to 131I radioimmunotherapy of refractory non-Hodgkin’s lymphoma by Roberson, Peter L., Amro, Hanan, Wilderman, Scott J., Avram, Anca M., Kaminski, Mark S., Schipper, Matthew J., Dewaraja, Yuni K.

“…Purpose Improved data collection methods have improved absorbed dose estimation by tracking activity distributions and tumor extent at multiple time points,…”
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131I-tositumomab radioimmunotherapy: initial tumor dose-response results using 3-dimensional dosimetry including radiobiologic modeling by Dewaraja, Yuni K, Schipper, Matthew J, Roberson, Peter L, Wilderman, Scott J, Amro, Hanan, Regan, Denise D, Koral, Kenneth F, Kaminski, Mark S, Avram, Anca M

“…For optimal treatment planning in radionuclide therapy, robust tumor dose-response correlations must be established. Here, fully 3-dimensional (3D) dosimetry…”
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Accurate Dosimetry in 131I Radionuclide Therapy Using Patient-Specific, 3-Dimensional Methods for SPECT Reconstruction and Absorbed Dose Calculation by Dewaraja, Yuni K, Wilderman, Scott J, Ljungberg, Michael, Koral, Kenneth F, Zasadny, Kenneth, Kaminiski, Mark S

“…(131)I radionuclide therapy studies have not shown a strong relationship between tumor absorbed dose and response, possibly due to inaccuracies in activity…”
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A Deep Residual Learning Network for Practical Voxel Dosimetry in Radionuclide Therapy by Li, Zongyu, Fessler, Jeffrey A., Mikell, Justin K., Wilderman, Scott J., Dewaraja, Yuni K.

“…Current standard methods for voxel-level dosimetry in radionuclide therapy suffers from a tradeoff between accuracy and computational efficiency. Monte Carlo…”
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Experimental validation of the DPM Monte Carlo code using minimally scattered electron beams in heterogeneous media by Chetty, Indrin J, Moran, Jean M, Nurushev, Teamor S, McShan, Daniel L, Fraass, Benedick A, Wilderman, Scott J, Bielajew, Alex F

“…A comprehensive set of measurements and calculations has been conducted to investigate the accuracy of the Dose Planning Method (DPM) Monte Carlo code for…”
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Benchmarking of the Dose Planning Method (DPM) Monte Carlo code using electron beams from a racetrack microtron by Chetty, Indrin J., Moran, Jean M., McShan, Daniel L., Fraass, Benedick A., Wilderman, Scott J., Bielajew, Alex F.

“…A comprehensive set of measurements and calculations has been conducted to investigate the accuracy of the Dose Planning Method (DPM) Monte Carlo code for dose…”
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Technical note: Impact of dose voxel kernel (DVK) values on dosimetry estimates in 177 Lu and 90 Y radiopharmaceutical therapy (RPT) applications by Danieli, Rachele, Pistone, Daniele, Tranel, Jonathan, Botta, Francesca, Uribe-Munoz, Carlos, Raspanti, Davide, Salvat, Francesc, Wilderman, Scott J, Bardiès, Manuel, Amato, Ernesto, Dewaraja, Yuni K, Cremonesi, Marta

“…Radiopharmaceutical therapy (RPT) is an increasingly adopted modality for treating cancer. There is evidence that the optimization of the treatment based on…”
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A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177 Lu-Peptide Receptor Radionuclide Therapy by Dewaraja, Yuni K, Mirando, David M, Peterson, Avery B, Niedbala, Jeremy, Millet, John D, Mikell, Justin K, Frey, Kirk A, Wong, Ka Kit, Wilderman, Scott J, Nelson, Aaron S

“…Patient-specific dosimetry in radiopharmaceutical therapy (RPT) is impeded by the lack of tools that are accurate and practical for the clinic. Our aims were…”
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Determining detector requirements for medical imaging applications by Clinthorne, Neal H., Ng, Chor-yi, Strobel, Joerg, Hua, Chia-ho, LeBlanc, James W., Wilderman, Scott J., Rogers, W.Leslie

“…The Cramér–Rao lower bound on estimator variance is used as a tool for assessing radiation detector requirements for nuclear medicine imaging. The classical…”
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Quantum noise in digital X-ray image detectors with optically coupled scintillators by Flynn, M.J., Hames, S.M., Wilderman, S.J., Ciarelli, J.J.

“…Digital X-ray imaging detectors designed for soft X-rays (1 to 50 keV) are significant for medical mammography, dental radiography, microradiography, and…”
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