Search Results - "Wilder, Ronald L."

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial by Sherry, Nicole, Dr, Hagopian, William, MD, Ludvigsson, Johnny, Prof, Jain, Sunil M, MD, Wahlen, Jack, MD, Ferry, Robert J, Prof, Bode, Bruce, MD, Aronoff, Stephen, MD, Holland, Christopher, MS, Carlin, David, PhD, King, Karen L, MS, Wilder, Ronald L, MD, Pillemer, Stanley, MD, Bonvini, Ezio, MD, Johnson, Syd, PhD, Stein, Kathryn E, PhD, Koenig, Scott, MD, Herold, Kevan C, Prof, Daifotis, Anastasia G, MD

“…Summary Background Findings of small studies have suggested that short treatments with anti-CD3 monoclonal antibodies that are mutated to reduce Fc receptor…”
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Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans? by Elenkov, Ilia J, Kvetnansky, Richard, Hashiramoto, Akira, Bakalov, Vladimir K, Link, Amrey A, Zachman, Keith, Crane, Marianna, Jezova, Daniela, Rovensky, Jozef, Dimitrov, Mariana A, Gold, Philip W, Bonini, Sergio, Fleisher, Thomas, Chrousos, George P, Wilder, Ronald L

“…Immunogenetic mechanisms operating within the immune system are known to influence cytokine profiles and disease susceptibility. Yet the role of the…”
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Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors by Elenkov, Ilia J, Webster, Elizabeth, Papanicolaou, Dimitris A, Fleisher, Thomas A, Chrousos, George P, Wilder, Ronald L

“…IL-12 and IL-10, respectively, stimulate Th1 and Th2 immune responses. The development of some allergic reactions, infections, and tumors are associated with…”
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Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes by Link, Amrey A, Kino, Tomoshige, Worth, James A, McGuire, Jennifer L, Crane, Marianna L, Chrousos, George P, Wilder, Ronald L, Elenkov, Ilia J

“…Adenosine (ADO) exerts potent anti-inflammatory and immunosuppressive effects. In this paper we address the possibility that these effects are partly mediated…”
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Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo by Karalis, Katia, Sano, Hajime, Redwine, Jeffrey, Listwak, Sam, Wilder, Ronald L., Chrousos, George P.

“…Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors…”
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A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats by Remmers, Elaine F, Longman, Ryan E, Du, Ying, O'Hare, Ann, Cannon, Grant W, Griffiths, Marie M, Wilder, Ronald L

“…Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in humans has been hampered by several factors,…”
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Hormones, Pregnancy, and Autoimmune Diseases by WILDER, RONALD L.

“…: Hormonal factors linked to age, gender, and reproductive status are undoubtedly involved in regulating the onset of numerous autoimmune diseases. For…”
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Mutation of macrophage colony stimulating factor ( Csf1) causes osteopetrosis in the tl rat by Dobbins, David E, Sood, Raman, Hashiramoto, Akira, Hansen, Carl T, Wilder, Ronald L, Remmers, Elaine F

“…Osteopetrosis results from a heterogeneous group of congenital bone diseases that display inadequate osteoclastic bone resorption. We recently mapped tl…”
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Neuroimmunoendocrinology of the rheumatic diseases: past, present, and future by Wilder, Ronald L

“…Adaptation to stressful stimuli, maintenance of homeostasis, and ultimately, survival require bidirectional feedback communication among components of the…”
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Expression of cyclooxygenase-1 and -2 in human colorectal cancer by SANO, H, KAWAHITO, Y, WILDER, R. L, HASHIRAMOTO, A, MUKAI, S, ASAI, K, KIMURA, S, KATO, H, KONDO, M, HLA, T

“…Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin, aspirin, sulindac, and piroxicam reduce the risk of colon cancer…”
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A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases by Jawaheer, Damini, Seldin, Michael F., Amos, Christopher I., Chen, Wei V., Shigeta, Russell, Monteiro, Joanita, Kern, Marlene, Criswell, Lindsey A., Albani, Salvatore, Nelson, J. Lee, Clegg, Daniel O., Pope, Richard, Schroeder, Harry W., Bridges, S. Louis, Pisetsky, David S., Ward, Ryk, Kastner, Daniel L., Wilder, Ronald L., Pincus, Theodore, Callahan, Leigh F., Flemming, Donald, Wener, Mark H., Gregersen, Peter K.

“…Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex…”
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Pilot clinical trial of intravenous doxycycline versus placebo for rheumatoid arthritis by PILLEMER, Stanley, GULKO, Percio, WILDER, Ronald L, LIGIER, Sophie, YARBORO, Cheryl, GOURLEY, Mark, GOLDBACH-MANSKY, Raphaela, SIEGEL, Richard, HIRSCH, Rosemarie, PUCINO, Frank, TILLEY, Barbara

“…OBJECTIVE: To screen for potential efficacy and assess the feasibility of intravenous (IV) doxycycline as a treatment for rheumatoid arthritis (RA). METHODS:…”
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Cyclical expression of GnRH and GnRH receptor mRNA in lymphoid organs by Jacobson, J D, Crofford, L J, Sun, L, Wilder, R L

“…Gonadotropin-releasing hormone (GnRH) is known to possess direct immunomodulatory effects. We have previously demonstrated that the administration of GnRH…”
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Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset by Goldbach-Mansky, R, Lee, J, McCoy, A, Hoxworth, J, Yarboro, C, Smolen, J S, Steiner, G, Rosen, A, Zhang, C, Ménard, H A, Zhou, Z J, Palosuo, T, Van Venrooij, W J, Wilder, R L, Klippel, J H, Schumacher, Jr, H R, El-Gabalawy, H S

“…STATEMENT OF FINDINGS: An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and…”
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Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis by Ben-Av, Pazit, Crofford, Leslie J., Wilder, Ronald L., Hla, Timothy

“…Inflammatory mediators such as prostaglandin E 2 (PGE 2) and interleukin-1 (IL-1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE 2…”
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Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis by Crofford, Leslie J, Kalogeras, Konstantine T, Mastorakos, George, Magiakou, Maria-Alexandra, Wells, Jana, Kanik, Keith S, Gold, Philip W, Chrousos, George P, Wilder, Ronald L

“…Systemic symptoms in rheumatoid arthritis (RA) are mediated, at least in part, by elevated levels of circulating interleukin (IL)-6, and this cytokine is also…”
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The Non-MHC Quantitative Trait Locus Cia5 Contains Three Major Arthritis Genes That Differentially Regulate Disease Severity, Pannus Formation, and Joint Damage in Collagen- and Pristane-Induced Arthritis by Brenner, Max, Meng, Hsiang-Chi, Yarlett, Nuriza C, Joe, Bina, Griffiths, Marie M, Remmers, Elaine F, Wilder, Ronald L, Gulko, Percio S

“…Cia5 is a locus on rat chromosome 10 which regulates the severity of collagen- and pristane-induced arthritis (CIA and PIA). To refine the region toward…”
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Mapping autoimmunity genes by Griffiths, Marie M, Encinas, Jeffrey A, Remmers, Elaine F, Kuchroo, Vijay K, Wilder, Ronald L

“…Rat and mouse models for the major human autoimmune/inflammatory diseases are under intense genetic scrutiny. Genome-wide linkage studies reveal that each…”
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Localization of Quantitative Trait Loci Regulating Adjuvant-Induced Arthritis in Rats: Evidence for Genetic Factors Common to Multiple Autoimmune Diseases by Kawahito, Yutaka, Cannon, Grant W, Gulko, Percio S, Remmers, Elaine F, Longman, Ryan E, Reese, Van R, Wang, Jianping, Griffiths, Marie M, Wilder, Ronald L

“…Adjuvant-induced arthritis (AIA) in rats is a widely used autoimmune experimental model with many features similar to rheumatoid arthritis (RA). To identify…”
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Genetic dissection of a rat model for rheumatoid arthritis : significant gender influences on autosomal modifier loci by FURUYA, Takefumi, SALSTROM, Jennifer L, MCCALL-VINING, Shawna, CANNON, Grant W, JOE, Bina, REMMERS, Elaine F, GRIFFITHS, Marie M, WILDER, Ronald L

“…Rheumatoid arthritis (RA) is a common, chronic, autoimmune, inflammatory disease that is influenced by genetic factors including gender. Many studies suggest…”
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