Search Results - "Wilder, RL"

Hormonal Regulation of Tumor Necrosis Factor-α, Interleukin-12 and Interleukin-10 Production by Activated Macrophages: A Disease-modifying Mechanism in Rheumatoid Arthritis and Systemic Lupus Erythematosus? by WILDER, RONALD L., ELENKOV, ILIA J.

“…Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) frequently develop and progress in settings in which sympathoadrenomedullary and gonadal…”
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The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system by Elenkov, I J, Wilder, R L, Chrousos, G P, Vizi, E S

“…The brain and the immune system are the two major adaptive systems of the body. During an immune response the brain and the immune system "talk to each other"…”
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Neuroendocrine-Immune System Interactions and Autoimmunity by Wilder, R L

“…The concept of an integrated bidirectionally regulated neuroendocrine-immune adaptive response to stress has strong experimental support. The quality and…”
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IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway by Case, JP, Lafyatis, R, Kumkumian, GK, Remmers, EF, Wilder, RL

“…IL-1, like other agents that have been shown a capacity to induce protein kinase C, is a potent transcriptional activator of the metalloproteinase,…”
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The pathophysiologic roles of interleukin-6 in human disease by PAPANICOLAOU, D. A, WILDER, R. L, MANOLAGAS, S. C, CHROUSOS, G. P

“…Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of action. Apart from its hematologic, immune, and hepatic effects, it…”
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Neuroimmunoendocrinology of the rheumatic diseases: past, present, and future by Wilder, Ronald L

“…Adaptation to stressful stimuli, maintenance of homeostasis, and ultimately, survival require bidirectional feedback communication among components of the…”
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Responses of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis to interleukin‐6: A pilot study in fibromyalgia by Torpy, David J., Papanicolaou, Dimitris A., Lotsikas, Angela J., Wilder, Ronald L., Chrousos, George P., Pillemer, Stanley R.

“…Objective To determine whether deficient activity of the hypothalamic corticotropin‐releasing hormone (CRH) neuron, which stimulates the…”
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Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases by Wilder, R L

“…A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage…”
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A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases by Jawaheer, Damini, Seldin, Michael F., Amos, Christopher I., Chen, Wei V., Shigeta, Russell, Monteiro, Joanita, Kern, Marlene, Criswell, Lindsey A., Albani, Salvatore, Nelson, J. Lee, Clegg, Daniel O., Pope, Richard, Schroeder, Harry W., Bridges, S. Louis, Pisetsky, David S., Ward, Ryk, Kastner, Daniel L., Wilder, Ronald L., Pincus, Theodore, Callahan, Leigh F., Flemming, Donald, Wener, Mark H., Gregersen, Peter K.

“…Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex…”
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Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset by Goldbach-Mansky, R, Lee, J, McCoy, A, Hoxworth, J, Yarboro, C, Smolen, J S, Steiner, G, Rosen, A, Zhang, C, Ménard, H A, Zhou, Z J, Palosuo, T, Van Venrooij, W J, Wilder, R L, Klippel, J H, Schumacher, Jr, H R, El-Gabalawy, H S

“…STATEMENT OF FINDINGS: An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and…”
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Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors by Elenkov, Ilia J, Webster, Elizabeth, Papanicolaou, Dimitris A, Fleisher, Thomas A, Chrousos, George P, Wilder, Ronald L

“…IL-12 and IL-10, respectively, stimulate Th1 and Th2 immune responses. The development of some allergic reactions, infections, and tumors are associated with…”
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Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases by Wilder, RL

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Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis by Ben-Av, Pazit, Crofford, Leslie J., Wilder, Ronald L., Hla, Timothy

“…Inflammatory mediators such as prostaglandin E 2 (PGE 2) and interleukin-1 (IL-1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE 2…”
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Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes by Link, Amrey A, Kino, Tomoshige, Worth, James A, McGuire, Jennifer L, Crane, Marianna L, Chrousos, George P, Wilder, Ronald L, Elenkov, Ilia J

“…Adenosine (ADO) exerts potent anti-inflammatory and immunosuppressive effects. In this paper we address the possibility that these effects are partly mediated…”
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Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia by Crofford, L J, Pillemer, S R, Kalogeras, K T, Cash, J M, Michelson, D, Kling, M A, Sternberg, E M, Gold, P W, Chrousos, G P, Wilder, R L

“…To examine basal and stimulated hypothalamic-pituitary-adrenal (HPA) axis and related hormone levels, including adrenocorticotropin (ACTH), cortisol, arginine…”
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Glucocorticoid therapy for immune-mediated diseases : basic and clinical correlates by BOUMPAS, D. T, CHROUSOS, G. P, WILDECR, R. L, CUPPS, T. R, BALOW, J. E

“…Glucocorticoids are pleiotropic hormones that at pharmacologic doses prevent or suppress inflammation and other immunologically mediated processes. At the…”
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The Non-MHC Quantitative Trait Locus Cia5 Contains Three Major Arthritis Genes That Differentially Regulate Disease Severity, Pannus Formation, and Joint Damage in Collagen- and Pristane-Induced Arthritis by Brenner, Max, Meng, Hsiang-Chi, Yarlett, Nuriza C, Joe, Bina, Griffiths, Marie M, Remmers, Elaine F, Wilder, Ronald L, Gulko, Percio S

“…Cia5 is a locus on rat chromosome 10 which regulates the severity of collagen- and pristane-induced arthritis (CIA and PIA). To refine the region toward…”
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Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones : Failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis by CROFFORD, L. J, KALOGERAS, K. T, MASTORAKOS, G, MAGIAKOU, M.-A, WELLS, J, KANIK, K. S, GOLD, P. W, CHROUSOS, G. P, WILDER, R. L

“…Systemic symptoms in rheumatoid arthritis (RA) are mediated, at least in part, by elevated levels of circulating interleukin (IL)-6, and this cytokine is also…”
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Hormonal alterations in rheumatoid arthritis, including the effects of pregnancy by Kanik, K S, Wilder, R L

“…A number of hormonal abnormalities are present in RA patients. A major theme of these abnormalities seems to be that deficiencies in the production or action…”
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The stress response and the regulation of inflammatory disease by Sternberg, E M, Chrousos, G P, Wilder, R L, Gold, P W

“…The molecular and biochemical bases for interactions between the immune and central nervous systems are described. Immune cytokines not only activate immune…”
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