Search Results - "Wildenberger, Kathrin"

Optimized Digital Droplet PCR for BCR-ABL by Maier, Jacqueline, Lange, Thoralf, Cross, Michael, Wildenberger, Kathrin, Niederwieser, Dietger, Franke, Georg-Nikolaus

“…Quantitative real-time PCR methods are commonly used to monitor BCR-ABL transcript levels in patients with chronic myelogenous leukemia. However, standard…”
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Comparison of Real-Time Quantitative PCR and Digital Droplet PCR for BCR-ABL1 Monitoring in Patients with Chronic Myeloid Leukemia by Franke, Georg-Nikolaus, Maier, Jacqueline, Wildenberger, Kathrin, Cross, Michael, Giles, Francis J., Müller, Martin C., Hochhaus, Andreas, Niederwieser, Dietger, Lange, Thoralf

“…Real-time quantitative PCR (qPCR) is routinely used to detect minimal residual disease in chronic myeloid leukemia patients. The absolute quantification with…”
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Increasing the Sensitivity of BCR-ABL Monitoring By Digital PCR By Reducing the Background Noise by Franke, Georg-Nikolaus, Maier, Jacqueline, Tzonev, Svilen, Shelton, Dawne Naomi, Cross, Michael, Wildenberger, Kathrin, Niederwieser, Dietger, Lange, Thoralf

“…Background Droplet digital PCR (dPCR) is a potentially appealing technology for quantitative detection of specific mutations with simultaneous measurement of…”
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Incidence of Low Level Mutations in Newly Diagnosed CML Patients: A Substudy of the German Tiger Trial by Franke, Georg-Nikolaus, Maier, Jacqueline, Wildenberger, Kathrin, Günther, Christine, Cross, Michael, Ernst, Thomas, Fabisch, Christian, Niederwieser, Dietger, Hochhaus, Andreas, Lange, Thoralf

“…Background: The presence of BCR-ABL kinase domain mutations below the detection limit of Sanger sequencing (low level mutations, LLM) predicts the outcome of…”
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Prognostic impact of the CD34+/CD38− cell burden in patients with acute myeloid leukemia receiving allogeneic stem cell transplantation by Jentzsch, Madlen, Bill, Marius, Nicolet, Deedra, Leiblein, Sabine, Schubert, Karoline, Pless, Martina, Bergmann, Ulrike, Wildenberger, Kathrin, Schuhmann, Luba, Cross, Michael, Pönisch, Wolfram, Franke, Georg‐Nikolaus, Vucinic, Vladan, Lange, Thoralf, Behre, Gerhard, Mrózek, Krzysztof, Bloomfield, Clara D., Niederwieser, Dietger, Schwind, Sebastian

“…In acute myeloid leukemia (AML), leukemia‐initiating cells exist within the CD34+/CD38− cell compartment. They are assumed to be more resistant to…”
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A Comparison of Droplet Digital PCR and Quantitative RT-PCR for Low Level BCR-ABL in CML Patients with Molecular Responses by Maier, Jacqueline, Franke, Georg-Nikolaus, Schubert, Karoline, Wildenberger, Kathrin, Cross, Michael, Niederwieser, Dietger, Lange, Thoralf

“…Droplet Digital PCR (ddPCR) is based on the separation of a standard PCR reaction into many thousand single droplets, each of which is tested independently for…”
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Quantification of BCR-ABL by digital PCR in samples with high copy numbers and rates of molecular responses (as defined by EUTOS) compared to those detected with standard quantitative real-time PCR by Franke, Georg-Nikolaus, Maier, Jacqueline, Cross, Michael, Wildenberger, Kathrin, Giles, Francis J., Frank, Oliver, Hochhaus, Andreas, Dietz, Christian, Müller, Martin C., Niederwieser, Dietger, Lange, Thoralf

“…Abstract only…”
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Quantification of BCR-ABL with Digital PCR Results in a Significantly Lower Rate of Deep Molecular Responses When Compared to RT-qPCR in CML Patients Treated in the ENEST1st Trial by Franke, Georg-Nikolaus, Maier, Jacqueline, Wildenberger, Kathrin, Cross, Michael, Frank, Oliver, Giles, Frank, Hochhaus, Andreas, Dietz, Christian T., Müller, Martin C., Niederwieser, Dietger, Lange, Thoralf

“…▪ Digital PCR (dPCR) generates an absolute read out that is largely tolerant to variations in PCR efficiency, reducing the requirement for standardisation like…”
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High Blood BAALC Copy Numbers Determined By Digital Droplet PCR at Timepoint of Allogeneic Transplantation in Complete Remission Predicts Relapse in Patients with Acute Myeloid Leukemia by Jentzsch, Madlen, Bill, Marius, Schulz, Julia, Grimm, Juliane, Beinicke, Stefanie, Schubert, Karoline, Haentschel, Janine, Wildenberger, Kathrin, Schmalbrock, Laura Katharina, Bonifacio, Lynn Baquiran, Poenisch, Wolfram, Behre, Gerhard, Franke, Georg-Nikolaus, Lange, Thoralf, Vucinic, Vladan, Niederwieser, Dietger, Schwind, Sebastian

“…Allogeneic hematopoietic cell transplantation (HSCT) is a powerful consolidation option for acute myeloid leukemia (AML) patients (pts) in hematologic complete…”
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Low Level BCR-ABL Mutations and Response to Treatment: A Substudy of the ENEST1st Trial by Franke, Georg-Nikolaus, Maier, Jacqueline, Schubert, Karoline, Cross, Michael, Leiblein, Sabine, Wildenberger, Kathrin, Giles, Frank, Hochhaus, Andreas, Frank, Oliver, Niederwieser, Dietger, Lange, Thoralf

“…The presence of BCR-ABL kinase domain mutations below the detection limit of sanger sequencing (low level mutations, LLM) predicts the outcome of subsequent…”
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Low Level BCR-ABL Mutations Below the Detection Limit of Current Standard Screening Techniques Occur Predominantly in the CD34+ Progenitor Cell Compartment in Chronic Phase CML Patients At Diagnosis. A Substudy of the ENEST1st Trial by Maier, Jacqueline, Schubert, Karoline, Cross, Michael, Leiblein, Sabine, Wildenberger, Kathrin, Giles, Frank, Hochhaus, Andreas, Frank, Oliver, Niederwieser, Dietger, Lange, Thoralf

“…Abstract 1671 The presence of BCR-ABL kinase domain mutations below the detection limit of conventional screening techniques (low level mutations, LLM)…”
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High Expression of Mir-9 down-Regulates the Poor Outcome Prognosticator ERG and Associates with Reduced Relapse-Rates in Acute Myeloid Leukemia by Weidner, Heike, Bill, Marius, Schmalbrock, Laura, Jentzsch, Madlen, Kloss, Laura, Gaber, Taqiuddine, Bonifacio, Lynn, Schubert, Karoline, Wildenberger, Kathrin, Gerloff, Dennis, Vucinic, Vladan, Franke, Georg-Nikolaus, Lange, Thoralf, Cross, Michael, Fricke, Stephan, Behre, Gerhard, Niederwieser, Dietger, Schwind, Sebastian

“…▪ In acute myeloid leukemia (AML) high expression of the transcription factor ERG (ETS related gene) is associated with dismal outcome. The mechanisms that…”
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High Pri-Mir-181a-1 and Pri-Mir-181a-2 Expression Associates with Improved Outcomes in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation after Reduced Intensity Conditioning by Schwind, Sebastian, Jentzsch, Madlen, Bill, Marius, Schubert, Karoline, Schmalbrock, Laura, Weidner, Heike, Kloss, Laura, Gaber, Taqiuddine, Bonifacio, Lynn, Wildenberger, Kathrin, Pönisch, Wolfram, Vucinic, Vladan, Franke, Georg-Nikolaus, Lange, Thoralf, Cross, Michael, Behre, Gerhard, Niederwieser, Dietger

“…Introduction: Despite progress in understanding acute myeloid leukemia (AML) biology, most patients (pts) still have a poor prognosis. MicroRNAs (miR) have…”
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Prognostic Implications of Pri-Mir-320a Expression in Acute Myeloid Leukemia Patients by Gaber, Taqiuddine, Bill, Marius, Jentzsch, Madlen, Schubert, Karoline, Weidner, Heike, Kloss, Laura, Schmalbrock, Laura, Lynn, Bonifacio, Wildenberger, Kathrin, Pönisch, Wolfram, Vucinic, Vladan, Franke, Georg-Nikolaus, Lange, Thoralf, Cross, Michael, Behre, Gerhard, Niederwieser, Dietger, Schwind, Sebastian

“…Background: Most acute myeloid leukemia (AML) patients (pts) stilldo not achieve long-term survival. Better risk stratification and novel therapeutic avenues…”
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The Prognostic Impact of the Mutational Profile in Patients with Myelofibrosis in the Era of the JAK1/JAK2-Inhibitor Ruxolitinib by Al-Ali, Haifa Kathrin, Wang, Song-Yau, Jaekel, Nadja, Koehler, Anne, Krahl, Rainer, Hubert, Karolin, Lange, Thoralf, Roskos, Martin, Stengel, Rayak, Kovacs, Ines, Scarlett, Schwabe, Schubert, Karoline, Wildenberger, Kathrin, Schneider, Melanie, Koehler, Elisabeth, Niederwieser, Dietger

“…In retrospective studies, CALR mutation is found to be a favorable prognostic variable in myelofibrosis (MF) compared with JAK2, or MPL mutations. With the…”
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Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma by Pscherer, Armin, Schliwka, Julia, Wildenberger, Kathrin, Mincheva, Antoaneta, Schwaenen, Carsten, Döhner, Hartmut, Stilgenbauer, Stephan, Lichter, Peter

“…A broad range of malignant diseases, such as mantle cell lymphoma (MCL), is associated with complex genomic alterations, demanding multimodal functional…”
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BCR-ABL Kinase Domain Mutations in the P-Loop and at Imatinib Contact Sites in CML Patients with Imatinib Resistance Are Associated with Higher Maximum Imatinib Doses by Pelz-Ackermann, Oliver, Deininger, Michael W.N., Cross, Michael, Wildenberger, Kathrin, Krahl, Rainer, Wang, Song-Yau, Al-Ali, Haifa K., Niederwieser, Dietger W., Lange, Thoralf

“…Objectives: Acquired resistance to imatinib (IM) in patients with chronic myeloid leukaemia (CML) is frequently due to mutations of the BCR-ABL kinase domain…”
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Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes by Kalla, Claudia, Nentwich, Hagen, Schlotter, Magdalena, Mertens, Daniel, Wildenberger, Kathrin, Döhner, Hartmut, Stilgenbauer, Stephan, Lichter, Peter

“…Deletion of chromosome region 11q22–q23 defines a subgroup of patients with B‐cell chronic lymphocytic leukemia (B‐CLL) characterized by poor survival…”
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Accumulation of hexoses in leaf vacuoles: Studies with transgenic tobacco plants expressing yeast-derived invertase in the cytosol, vacuole or apoplasm by Heineke, D. (Goettingen Univ. (Germany). Inst. fuer Biochemie der Pflanze), Wildenburger, K, Sonnewald, U, Willmitzer, L, Heldt, H.W

“…The subcellular distribution of hexoses, sucrose and amino acids among the stromal, cytosolic and vacuolar compartments was analysed by a nonaqueous…”
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