Search Results - "Wildenberg, Manon E."

Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease by Levin, Alon D., Wildenberg, Manon E., van den Brink, Gijs R.

“…Several anti-tumour necrosis factor [TNF] blocking strategies have been evaluated in patients with Crohn’s disease. Compounds that have been tested included…”
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Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study by Duijvestein, Marjolijn, Vos, Anne Christine W, Roelofs, Helene, Wildenberg, Manon E, Wendrich, Barbara B, Verspaget, Henricus W, Kooy-Winkelaar, Engelina M C, Koning, Frits, Zwaginga, Jaap Jan, Fidder, Herma H, Verhaar, Auke P, Fibbe, Willem E, van den Brink, Gijs R, Hommes, Daniel W

“…Mesenchymal stromal cells (MSCs) are pluripotent cells that have immunosuppressive effects both in vitro and in experimental colitis. Promising results of MSC…”
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Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth by Karpus, Olga N., Westendorp, B. Florien, Vermeulen, Jacqueline L.M., Meisner, Sander, Koster, Jan, Muncan, Vanesa, Wildenberg, Manon E., van den Brink, Gijs R.

“…Intestinal epithelial cells have a defined hierarchy with stem cells located at the bottom of the crypt and differentiated cells more at the top. Epithelial…”
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Monocyte TREM-1 Levels Associate With Anti-TNF Responsiveness in IBD Through Autophagy and Fcγ-Receptor Signaling Pathways by Prins, Marileen M, Verstockt, Bram, Ferrante, Marc, Vermeire, Séverine, Wildenberg, Manon E, Koelink, Pim J

“…The expression of ( has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-α monoclonal antibody (mAb) therapy responsiveness in…”
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Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning by Navis, Marit, Martins Garcia, Tânia, Renes, Ingrid B, Vermeulen, Jacqueline LM, Meisner, Sander, Wildenberg, Manon E, van den Brink, Gijs R, van Elburg, Ruurd M, Muncan, Vanesa

“…During the suckling‐to‐weaning transition, the intestinal epithelium matures, allowing digestion of solid food. Transplantation experiments with rodent fetal…”
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Systemic increase in type I interferon activity in Sjögren's syndrome: A putative role for plasmacytoid dendritic cells by Wildenberg, Manon E, van Helden-Meeuwsen, Cornelia G, van de Merwe, Joop P, Drexhage, Hemmo A, Versnel, Marjan A

“…In the salivary glands of primary Sjögren's syndrome (pSjS) patients, type I IFN activity is increased, but systemic levels of type I IFN proteins are rarely…”
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T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model by Saris, Job, Bootsma, Sanne, Verhoeff, Jan, Tuynman, Jurriaan B, Wildenberg, Manon E, Rijnstra, Esther Siteur-van, Lenos, Kristiaan J, Garcia Vallejo, Juan J, Vermeulen, Louis, Grootjans, Joep

“…The occurrence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) has a dismal prognosis. There is often limited response to systemic- and…”
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FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming by Hansen, Ivo S., Krabbendam, Lisette, Bernink, Jochem H., Loayza-Puch, Fabricio, Hoepel, Willianne, van Burgsteden, Johan A., Kuijper, Elsa C., Buskens, Christianne J., Bemelman, Willem A., Zaat, Sebastiaan A. J., Agami, Reuven, Vidarsson, Gestur, van den Brink, Gijs R., de Jong, Esther C., Wildenberg, Manon E., Baeten, Dominique L. P., Everts, Bart, den Dunnen, Jeroen

“…CD103 + dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic…”
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Blimp1 regulates the transition of neonatal to adult intestinal epithelium by Muncan, Vanesa, Heijmans, Jarom, Krasinski, Stephen D., Büller, Nikè V., Wildenberg, Manon E., Meisner, Sander, Radonjic, Marijana, Stapleton, Kelly A., Lamers, Wout H., Biemond, Izak, van den Bergh Weerman, Marius A., O'Carroll, Dónal, Hardwick, James C., Hommes, Daniel W., van den Brink, Gijs R.

“…In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of…”
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Development of Fibrosis in Acute and Longstanding Ulcerative Colitis by de Bruyn, Jessica R., Meijer, Sybren L., Wildenberg, Manon E., Bemelman, Willem A., van den Brink, Gijs R., D’Haens, Geert R.

“…Background: Intestinal fibrosis is a process driven by chronic inflammation leading to increased presence of myofibroblasts and collagen deposition. Although…”
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Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease by de Bruyn, Jessica R, Becker, Marte A, Steenkamer, Jessica, Wildenberg, Manon E, Meijer, Sybren L, Buskens, Christianne J, Bemelman, Willem A, Löwenberg, Mark, Ponsioen, Cyriel Y, van den Brink, Gijs R, D'Haens, Geert R

“…Overt fibrostenotic disease is a relative contraindication for anti-TNF therapy in Crohn's disease. We hypothesized that subclinical fibrosis may also…”
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Beneficial Effect of Mildly Pasteurized Whey Protein on Intestinal Integrity and Innate Defense in Preterm and Near-Term Piglets by Navis, Marit, Muncan, Vanesa, Sangild, Per Torp, Møller Willumsen, Line, Koelink, Pim J, Wildenberg, Manon E, Abrahamse, Evan, Thymann, Thomas, van Elburg, Ruurd M, Renes, Ingrid B

“…The human digestive tract is structurally mature at birth, yet maturation of gut functions such as digestion and mucosal barrier continues for the next 1-2…”
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A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines by Adam, Aziza A A, van der Mark, Vincent A, Donkers, Joanne M, Wildenberg, Manon E, Oude Elferink, Ronald P J, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines…”
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A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients by Li Yim, Andrew Y F, de Bruyn, Jessica R, Duijvis, Nicolette W, Sharp, Catriona, Ferrero, Enrico, de Jonge, Wouter J, Wildenberg, Manon E, Mannens, Marcel M A M, Buskens, Christianne J, D'Haens, Geert R, Henneman, Peter, Te Velde, Anje A

“…The chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis and subsequent stenosis of the…”
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Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse by Wildenberg, Manon E, Vos, Anne Christine W, Wolfkamp, Simone C.S, Duijvestein, Marjolijn, Verhaar, Auke P, Te Velde, Anje A, van den Brink, Gijs R, Hommes, Daniel W

“…Background & Aims Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how…”
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Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA by Prins, Marileen M C, Giugliano, Francesca P, van Roest, Manon, van de Graaf, Stan F J, Koelink, Pim J, Wildenberg, Manon E

“…The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that…”
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Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade by Cloherty, Alexandra P. M., Rader, Anusca G., Patel, Kharishma S., Pérez-Vargas, Jimena, Thompson, Connor A. H., Ennis, Siobhan, Niikura, Masahiro, Wildenberg, Manon E., Muncan, Vanesa, Schreurs, Renée R. C. E., Jean, François, Ribeiro, Carla M. S.

“…SARS-CoV-2, the causative virus of COVID-19, continues to threaten global public health. COVID-19 is a multi-organ disease, causing not only respiratory…”
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Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis by de Krijger, Manon, Hageman, Ishtu L, Li Yim, Andrew Y F, Verhoeff, Jan, Garcia Vallejo, Juan J, van Hamersveld, Patricia H P, Levin, Evgeni, Hakvoort, Theodorus B M, Wildenberg, Manon E, Henneman, Peter, Ponsioen, Cyriel Y, de Jonge, Wouter J

“…Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with…”
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Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions by Strisciuglio, Caterina, Duijvestein, Marjolijn, Verhaar, Auke P., Vos, Anne Christine W., den Brink, Gijs R. van, Hommes, Daniel W., Wildenberg, Manon E.

“…Dendritic cells (DC) are key players in intestinal immunity, as these cells can direct the immune response to either a tolerogenic or an immunogenic phenotype…”
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Pro-inflammatory T cells-derived cytokines enhance the maturation of the human fetal intestinal epithelial barrier by Giugliano, Francesca P., Navis, Marit, Ouahoud, Sarah, Garcia, Tânia Martins, Kreulen, Irini A.M., Ferrantelli, Evelina, Meisner, Sander, Vermeulen, Jacqueline L.M., van Roest, Manon, Billaud, Jean-Noël, Koster, Jan, Dawood, Yousif, de Bakker, Bernadette S., Picavet-Havik, Daisy I., Schimmel, Irene M., van der Wel, Nicole N., Koelink, Pim J., Wildenberg, Manon E., Derikx, Joep P.M., de Jonge, Wouter J., Renes, Ingrid B., van Elburg, Ruurd M., Muncan, Vanesa

“…Small intestine (SI) maturation during early life is pivotal in preventing the onset of gut diseases. In this study we interrogated the milestones of SI…”
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