Search Results - "Wildeman, Bethany"
-
1
Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes
Published in Nature communications (18-03-2024)“…The molecular mechanisms of venetoclax-based therapy failure in patients with acute myeloid leukemia were recently clarified, but the mechanisms by which…”
Get full text
Journal Article -
2
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma
Published in Nature communications (08-02-2024)“…DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA…”
Get full text
Journal Article -
3
S185: TARGETING DNA2 OVERCOMES METABOLIC REPROGRAMMING IN 1Q21 MULTIPLE MYELOMA
Published in HemaSphere (08-08-2023)Get full text
Journal Article -
4
Differentially Methylated Genes in Muscle Associated with Gait Speed in a Non-Human Primate Model of Aging
Published in Innovation in aging (17-12-2021)“…Abstract Age-related changes in DNA methylation are potent regulators of gene expression and may in part explain the onset of disease and disability. Vervet…”
Get full text
Journal Article -
5
Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia
Published in Cell reports. Medicine (18-06-2024)“…RAS pathway mutations, which are present in 30% of patients with chronic myelomonocytic leukemia (CMML) at diagnosis, confer a high risk of resistance to and…”
Get full text
Journal Article