Kororamide A, a new tribrominated indole alkaloid from the Australian bryozoan Amathia tortuosa

A new tribrominated indole alkaloid, kororamide A together with the known alkaloid convolutamine F, were isolated through the application of mass directed purification from the bryozoan, Amathia tortuosa collected from northern New South Wales, Australia. The structure of kororamide A was deduced fr...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 53; no. 23; pp. 2873 - 2875
Main Authors: Carroll, Anthony R., Wild, Seanan J., Duffy, Sandra, Avery, Vicky M.
Format: Journal Article
Language:English
Published: Elsevier Ltd 06-06-2012
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Summary:A new tribrominated indole alkaloid, kororamide A together with the known alkaloid convolutamine F, were isolated through the application of mass directed purification from the bryozoan, Amathia tortuosa collected from northern New South Wales, Australia. The structure of kororamide A was deduced from the analysis of 1D/2D NMR and MS data. Kororamide A exists in solution as a mixture of interconverting cis–trans amide regioisomers in a ratio of 4:5. Bioactivity testing demonstrated that kororamide A was marginally active against chloroquine-sensitive and resistant strains of the malarial parasite Plasmodium falciparum, and was inactive against normal human cell lines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.03.126