Search Results - "Wild, James R."

Biodegradation of coumaphos, chlorferon, and diethylthiophosphate using bacteria immobilized in Ca-alginate gel beads by Ha, Jiyeon, Engler, Cady R., Wild, James R.

“…Calcium-alginate immobilized cell systems were developed for the detoxification and biodegradation of coumaphos, an organophosphate insecticide, and its…”
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Lysozyme-mediated formation of protein–silica nano-composites for biosensing applications by Ramanathan, Madhumati, Luckarift, Heather R., Sarsenova, Ainur, Wild, James R., Ramanculov, Erlan K., Olsen, Eric V., Simonian, Aleksandr L.

“…We demonstrate a rapid method for enzyme immobilization directly on a waveguide surface by encapsulation in a silica matrix. Organophosphate hydrolase (OPH),…”
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Poly(ethylene glycol) Hydrogel-Encapsulated Fluorophore−Enzyme Conjugates for Direct Detection of Organophosphorus Neurotoxins by Russell, Ryan J, Pishko, Michael V, Simonian, Aleksandr L, Wild, James R

“…A simple approach is described for preparing poly(ethylene glycol) hydrogel materials with encapsulated seminapthofluorescein (SNAFL)−organophosphorus…”
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Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines by Qian, Yongchang, Venkatraj, Jijayanagaram, Barhoumi, Rola, Pal, Ranadip, Datta, Aniruddha, Wild, James R., Tiffany-Castiglioni, Evelyn

“…The objective of this study was to evaluate the comparative non-cholinergic neurotoxic effects of paraoxon, which is acutely neurotoxic, and diisopropyl…”
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Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds by Hong, Marjorie S, Hong, Sandra J, Barhoumi, Rola, Burghardt, Robert C, Donnelly, K.C, Wild, James R, Venkatraj, Vijayanagaram, Tiffany-Castiglioni, Evelyn

“…Organophosphorus (OP) compounds used as insecticides and chemical warfare agents are known to cause potent neurotoxic effects in humans and animals…”
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Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol by Novikov, Boris N., Grimsley, Janet K., Kern, Rory J., Wild, James R., Wales, Melinda E.

“…A catalytic bioscavenger with broad substrate specificity for the therapeutic and prophylactic defense against recognized chemical threat agents has been a…”
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Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli by Rodríguez, Mauricio, Good, Theresa A., Wales, Melinda E., Hua, Jean P., Wild, James R.

“…With the emergence of multifaceted bioinformatics-derived data, it is becoming possible to merge biochemical and physiological information to develop a new…”
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Modification of Near Active Site Residues in Organophosphorus Hydrolase Reduces Metal Stoichiometry and Alters Substrate Specificity by diSioudi, Barbara, Grimsley, Janet K, Lai, Kaihua, Wild, James R

“…Organophosphorus hydrolase (OPH, EC 8.1.3.1) is a dimeric, bacterial enzyme that detoxifies many organophosphorus neurotoxins by hydrolyzing a variety of…”
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Biotransformation patterns of 2,4,6-trinitrotoluene by aerobic bacteria by Kalafut, T, Wales, M E, Rastogi, V K, Naumova, R P, Zaripova, S K, Wild, J R

“…2,4,6-Trinitrotoluene (TNT), a toxic nitroaromatic explosive, accumulates in the environment, making necessary the remediation of contaminated areas and unused…”
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Monitoring of diisopropyl fluorophosphate hydrolysis by fluoride-selective polymeric films using absorbance spectroscopy by Ramanathan, Madhumati, Wang, Lin, Wild, James R., Meyeroff, Mark E., Simonian, Aleksandr L.

“…In this study, a novel system for the detection and quantification of organofluorophosphonates (OFP) has been developed by using an optical sensing polymeric…”
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Orientation Specific Positioning of Organophosphorus Hydrolase on Solid Interfaces for Biosensor Applications by Reeves, Tony E, Paliwal, Sheetal, Wales, Melinda E, Wild, James R, Simonian, Aleksandr L

“…Protein immobilization on solid interfaces is a crucial aspect of their successful application in technologies such as biosensing, purification, separation,…”
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Biodegradation of chlorferon and diethylthiophosphate by consortia enriched from waste cattle dip solution by Ha, Jiyeon, Engler, Cady R., Wild, James R.

“…Chlorferon and diethylthiophosphate (DETP) are the hydrolysis products of coumaphos, an organophosphate pesticide. In this research, two consortia of bacterial…”
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Mechanism and stereochemical course at phosphorus of the reaction catalyzed by a bacterial phosphotriesterase by Lewis, Vincent E, Donarski, William J, Wild, James R, Raushel, Frank M

“…The reaction mechanism for the phosphotriesterase from Pseudomonas diminuta has been examined. When paraoxon (diethyl 4-nitrophenyl phosphate) is hydrolyzed by…”
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Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site by Grimsley, Janet K., Calamini, Barbara, Wild, James R., Mesecar, Andrew D.

“…Organophosphorus hydrolase detoxifies a broad range of organophosphate pesticides and the chemical warfare agents (CWAs) sarin and VX. Previously, rational…”
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Nerve agents degraded by enzymatic foams by LeJeune, Keith E, Wild, James R, Russell, Alan J

“…The decontamination of large areas that have been exposed to chemical weapons is a critical component of defence and anti-terrorist strategies around the…”
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Enzyme-based additives for paints and coatings by McDaniel, C. Steven, McDaniel, Jesse, Wales, Melinda E., Wild, James R.

“…Active enzymes and other active biomolecules sequestered in paints and coatings have the potential to provide one of the more unique surface coatings yet…”
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Genetically engineered resistance to organophosphate herbicides provides a new scoreable and selectable marker system for transgenic plants by Pinkerton, T. Scott, Howard, John A, Wild, James R

“…Organophosphate hydrolase (OPH, E.C. 3.1.8.1; encoded by the bacterial opd gene) provides a new scoreable and selectable genetic marker system for use in plant…”
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Organophosphorus Hydrolase Is a Remarkably Stable Enzyme That Unfolds through a Homodimeric Intermediate by Grimsley, Janet K, Scholtz, J. Martin, Pace, C. Nick, Wild, James R

“…Organophosphorus hydrolase (OPH, EC 8.1.3.1) is a homodimeric enzyme that catalyzes the hydrolysis of organophosphorus pesticides and nerve agents. We have…”
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Physicochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme by Budai, Marianna, Chapela, Patricia, Gróf, Pál, Zimmer, Andreas, Wales, Melinda E., Wild, James R., Klebovich, Imre, Petrikovics, Ilona, Szilasi, Mária

“…The present studies were focused on the preparation and characterization of stericaly stabilized liposomes (SLs) encapsulating a recombinant organophosphorus…”
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Characterization of oxidoreductase–redox polymer electrostatic film assembly on gold by surface plasmon resonance spectroscopy and Fourier transform infrared–external reflection spectroscopy by Simonian, Aleksandr L, Revzin, Alexander, Wild, James R, Elkind, Jerry, Pishko, Michael V

“…The electrostatic assembly of nanocomposite thin films consisting of alternating layers of an organometallic redox polymer (RP) and oxidoreductase enzymes,…”
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