Search Results - "Wild, Edward J."

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis by Byrne, Lauren M, MRes, Rodrigues, Filipe B, MD, Blennow, Kaj, Prof, Durr, Alexandra, Prof, Leavitt, Blair R, Prof, Roos, Raymund A C, Prof, Scahill, Rachael I, PhD, Tabrizi, Sarah J, Prof, Zetterberg, Henrik, Prof, Langbehn, Douglas, Prof, Wild, Edward J, Dr

“…Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Huntington's Disease Clinical Trials Corner: April 2020 by Rodrigues, Filipe B, Wild, Edward J

“…In this edition of the Huntington's Disease Clinical Trials Corner we expand on the UniQure AMT-130 and on the Neurocrine Biosciences KINECT-HD trials, and…”
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The use of wearable/portable digital sensors in Huntington's disease: A systematic review by Tortelli, Rosanna, Rodrigues, Filipe B., Wild, Edward J.

“…In chronic neurological conditions, wearable/portable devices have potential as innovative tools to detect subtle early disease manifestations and disease…”
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Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease by Rodrigues, Filipe Brogueira, Byrne, Lauren M, McColgan, Peter, Robertson, Nicola, Tabrizi, Sarah J, Zetterberg, Henrik, Wild, Edward J

“…Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and…”
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease by Björkqvist, Maria, Wild, Edward J, Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V, Benn, Caroline L, Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A, Hayden, Michael R, Khalili-Shirazi, Azadeh, Lowdell, Mark W, Brundin, Patrik, Bates, Gillian P, Leavitt, Blair R, Möller, Thomas, Tabrizi, Sarah J

“…Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral…”
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Lumbar puncture safety and tolerability in premanifest and manifest Huntington’s disease: a multi-analysis cross-sectional study by Hassan, Yara Refaat, Brogueira Rodrigues, Filipe, Zeun, Paul, Byrne, Lauren M., Estevez-Fraga, Carlos, Tortelli, Rosanna, Scahill, Rachael I., Wild, Edward J., Tabrizi, Sarah J.

“…Lumbar puncture (LP) has become increasingly common for people with Huntington’s disease (HD) both to administer intrathecal investigational medicinal products…”
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A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease by Boeddrich, Annett, Haenig, Christian, Neuendorf, Nancy, Blanc, Eric, Ivanov, Andranik, Kirchner, Marieluise, Schleumann, Philipp, Bayraktaroğlu, Irem, Richter, Matthias, Molenda, Christine Mirjam, Sporbert, Anje, Zenkner, Martina, Schnoegl, Sigrid, Suenkel, Christin, Schneider, Luisa-Sophie, Rybak-Wolf, Agnieszka, Kochnowsky, Bianca, Byrne, Lauren M, Wild, Edward J, Nielsen, Jørgen E, Dittmar, Gunnar, Peters, Oliver, Beule, Dieter, Wanker, Erich E

“…Alzheimer's disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in…”
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Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease by MUNSIE, Lise, CARON, Nicholas, SINGH ATWAL, Randy, MARSDEN, Ian, WILD, Edward J, BAMBURG, James R, TABRIZI, Sarah J, TRUANT, Ray

“…Huntington's disease (HD) is caused by an expanded CAG tract in the Interesting transcript 15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular…”
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Brain-derived neurotrophic factor in patients with Huntington's disease by Zuccato, Chiara, Marullo, Manuela, Vitali, Barbara, Tarditi, Alessia, Mariotti, Caterina, Valenza, Marta, Lahiri, Nayana, Wild, Edward J, Sassone, Jenny, Ciammola, Andrea, Bachoud-Lèvi, Anne Catherine, Tabrizi, Sarah J, Di Donato, Stefano, Cattaneo, Elena

“…Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's…”
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Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease by Lowe, Alexander J, Sjödin, Simon, Rodrigues, Filipe B, Byrne, Lauren M, Blennow, Kaj, Tortelli, Rosanna, Zetterberg, Henrik, Wild, Edward J

“…Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo. The…”
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A Remote Digital Monitoring Platform to Assess Cognitive and Motor Symptoms in Huntington Disease: Cross-sectional Validation Study by Lipsmeier, Florian, Simillion, Cedric, Bamdadian, Atieh, Tortelli, Rosanna, Byrne, Lauren M, Zhang, Yan-Ping, Wolf, Detlef, Smith, Anne V, Czech, Christian, Gossens, Christian, Weydt, Patrick, Schobel, Scott A, Rodrigues, Filipe B, Wild, Edward J, Lindemann, Michael

“…Background Remote monitoring of Huntington disease (HD) signs and symptoms using digital technologies may enhance early clinical diagnosis and tracking of…”
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Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington’s disease by Ou, Zhen-Yi Andy, Byrne, Lauren M., Rodrigues, Filipe B., Tortelli, Rosanna, Johnson, Eileanoir B., Foiani, Martha S., Arridge, Marzena, De Vita, Enrico, Scahill, Rachael I., Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J.

“…Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF function is reduced in Huntington’s disease (HD), possibly…”
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Huntington's Disease Clinical Trials Corner: June 2019 by Rodrigues, Filipe B, Ferreira, Joaquim J, Wild, Edward J

“…In this edition of the Huntington's Disease Clinical Trials Corner we expand on the HD-DBS and on the TRIHEP3 trials, and we list all currently registered and…”
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Therapies targeting DNA and RNA in Huntington's disease by Wild, Edward J, Tabrizi, Sarah J

“…No disease-slowing treatment exists for Huntington's disease, but its monogenic inheritance makes it an appealing candidate for the development of therapies…”
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Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays by Hensman Moss, Davina J, Robertson, Nicola, Farmer, Ruth, Scahill, Rachael I, Haider, Salman, Tessari, Michela A, Flynn, Geraldine, Fischer, David F, Wild, Edward J, Macdonald, Douglas, Tabrizi, Sarah J

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT)…”
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Huntington's Disease: The Most Curable Incurable Brain Disorder? by Wild, Edward J.

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Proteomic Profiling of Plasma in Huntington's Disease Reveals Neuroinflammatory Activation and Biomarker Candidates by Dalrymple, Annette, Wild, Edward J, Joubert, Richard, Sathasivam, Kirupa, Björkqvist, Maria, Petersén, Åsa, Jackson, Graham S, Isaacs, Jeremy D, Kristiansen, Mark, Bates, Gillian P, Leavitt, Blair R, Keir, Geoff, Ward, Malcolm, Tabrizi, Sarah J

“…Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to…”
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Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood by Runne, Heike, Kuhn, Alexandre, Wild, Edward J, Pratyaksha, Wirahpati, Kristiansen, Mark, Isaacs, Jeremy D, Régulier, Etienne, Delorenzi, Mauro, Tabrizi, Sarah J, Luthi-Carter, Ruth

“…Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's…”
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Tetrabenazine Versus Deutetrabenazine for Huntington's Disease: Twins or Distant Cousins? by Rodrigues, Filipe B., Duarte, Gonçalo S., Costa, João, Ferreira, Joaquim J., Wild, Edward J.

“…Background Tetrabenazine is the only US Food and Drug Administration‐approved drug for Huntington's disease, and deutetrabenazine was recently tested against…”
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