Search Results - "Wild, Edward"

Therapies targeting DNA and RNA in Huntington's disease by Wild, Edward J, Tabrizi, Sarah J

“…No disease-slowing treatment exists for Huntington's disease, but its monogenic inheritance makes it an appealing candidate for the development of therapies…”
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Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities by Tabrizi, Sarah J., Flower, Michael D., Ross, Christopher A., Wild, Edward J.

“…Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion in the huntingtin gene ( HTT ) and involves a complex web of pathogenic…”
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Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis by Byrne, Lauren M, MRes, Rodrigues, Filipe B, MD, Blennow, Kaj, Prof, Durr, Alexandra, Prof, Leavitt, Blair R, Prof, Roos, Raymund A C, Prof, Scahill, Rachael I, PhD, Tabrizi, Sarah J, Prof, Zetterberg, Henrik, Prof, Langbehn, Douglas, Prof, Wild, Edward J, Dr

“…Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We…”
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Targets for future clinical trials in Huntington's disease: What's in the pipeline? by Wild, Edward J., Tabrizi, Sarah J.

“…The known genetic cause of Huntington's disease (HD) has fueled considerable progress in understanding its pathobiology and the development of therapeutic…”
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Targeting Huntingtin Expression in Patients with Huntington’s Disease by Tabrizi, Sarah J, Leavitt, Blair R, Landwehrmeyer, G. Bernhard, Wild, Edward J, Saft, Carsten, Barker, Roger A, Blair, Nick F, Craufurd, David, Priller, Josef, Rickards, Hugh, Rosser, Anne, Kordasiewicz, Holly B, Czech, Christian, Swayze, Eric E, Norris, Daniel A, Baumann, Tiffany, Gerlach, Irene, Schobel, Scott A, Paz, Erika, Smith, Anne V, Bennett, C. Frank, Lane, Roger M

“…Mutated HTT , resulting in mutant huntingtin, causes Huntington’s disease. A phase 1–2a trial of intrathecal delivery of an antisense oligonucleotide targeting…”
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Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities by Tabrizi, Sarah J, Estevez-Fraga, Carlos, van Roon-Mom, Willeke M C, Flower, Michael D, Scahill, Rachael I, Wild, Edward J, Muñoz-Sanjuan, Ignacio, Sampaio, Cristina, Rosser, Anne E, Leavitt, Blair R

“…Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder; however, no disease-modifying interventions are available for patients…”
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Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease by Rodrigues, Filipe Brogueira, Byrne, Lauren M, McColgan, Peter, Robertson, Nicola, Tabrizi, Sarah J, Zetterberg, Henrik, Wild, Edward J

“…Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Huntington's Disease Clinical Trials Corner: April 2020 by Rodrigues, Filipe B, Wild, Edward J

“…In this edition of the Huntington's Disease Clinical Trials Corner we expand on the UniQure AMT-130 and on the Neurocrine Biosciences KINECT-HD trials, and…”
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Fluid and imaging biomarkers for Huntington's disease by Zeun, Paul, Scahill, Rachael I., Tabrizi, Sarah J., Wild, Edward J.

“…Huntington's disease is a chronic progressive neurodegenerative condition for which there is no disease-modifying treatment. The known genetic cause of…”
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The use of wearable/portable digital sensors in Huntington's disease: A systematic review by Tortelli, Rosanna, Rodrigues, Filipe B., Wild, Edward J.

“…In chronic neurological conditions, wearable/portable devices have potential as innovative tools to detect subtle early disease manifestations and disease…”
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Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis by Scahill, Rachael I, Zeun, Paul, Osborne-Crowley, Katherine, Johnson, Eileanoir B, Gregory, Sarah, Parker, Christopher, Lowe, Jessica, Nair, Akshay, O'Callaghan, Claire, Langley, Christelle, Papoutsi, Marina, McColgan, Peter, Estevez-Fraga, Carlos, Fayer, Kate, Wellington, Henny, Rodrigues, Filipe B, Byrne, Lauren M, Heselgrave, Amanda, Hyare, Harpreet, Sampaio, Cristina, Zetterberg, Henrik, Zhang, Hui, Wild, Edward J, Rees, Geraint, Robbins, Trevor W, Sahakian, Barbara J, Langbehn, Douglas, Tabrizi, Sarah J

“…Disease-modifying treatments are in development for Huntington's disease; crucial to their success is to identify a timepoint in a patient's life when there is…”
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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients by Wild, Edward J, Boggio, Roberto, Langbehn, Douglas, Robertson, Nicola, Haider, Salman, Miller, James R C, Zetterberg, Henrik, Leavitt, Blair R, Kuhn, Rainer, Tabrizi, Sarah J, Macdonald, Douglas, Weiss, Andreas

“…Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative…”
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Huntington disease by Bates, Gillian P., Dorsey, Ray, Gusella, James F., Hayden, Michael R., Kay, Chris, Leavitt, Blair R., Nance, Martha, Ross, Christopher A., Scahill, Rachael I., Wetzel, Ronald, Wild, Edward J., Tabrizi, Sarah J.

“…Huntington disease is devastating to patients and their families — with autosomal dominant inheritance, onset typically in the prime of adult life, progressive…”
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Brain-derived neurotrophic factor in patients with Huntington's disease by Zuccato, Chiara, Marullo, Manuela, Vitali, Barbara, Tarditi, Alessia, Mariotti, Caterina, Valenza, Marta, Lahiri, Nayana, Wild, Edward J, Sassone, Jenny, Ciammola, Andrea, Bachoud-Lèvi, Anne Catherine, Tabrizi, Sarah J, Di Donato, Stefano, Cattaneo, Elena

“…Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's…”
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One decade ago, one decade ahead in huntington's disease by Wild, Edward J., Tabrizi, Sarah J.

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Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease by Lowe, Alexander J, Sjödin, Simon, Rodrigues, Filipe B, Byrne, Lauren M, Blennow, Kaj, Tortelli, Rosanna, Zetterberg, Henrik, Wild, Edward J

“…Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo. The…”
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George Huntington: a legacy of inquiry, empathy and hope by Wexler, Alice, Wild, Edward J, Tabrizi, Sarah J

“…On the centenary of George Huntington's death, Wexler et.al. reconsider the setting and the collaborative effort that produced his description of “hereditary…”
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Natural history and burden of Huntington's disease in the UK: A population‐based cohort study by Furby, Hannah, Siadimas, Athanasios, Rutten‐Jacobs, Loes, Rodrigues, Filipe B., Wild, Edward J.

“…Background Huntington's disease (HD) is a rare neurodegenerative disease that presents with progressive psychological, cognitive and motor impairment. These…”
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Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease by Byrne, Lauren M, Rodrigues, Filipe B, Johnson, Eileanor B, Wijeratne, Peter A, De Vita, Enrico, Alexander, Daniel C, Palermo, Giuseppe, Czech, Christian, Schobel, Scott, Scahill, Rachael I, Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J

“…Huntington's disease (HD) is a genetic progressive neurodegenerative disorder, caused by a mutation in the gene, for which there is currently no cure. The…”
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