Search Results - "Wild, E. J."

Onset and Progression of Pathologic Atrophy in Huntington Disease: A Longitudinal MR Imaging Study by HOBBS, N. Z, BARNES, J, FROST, C, HENLEY, S. M. D, WILD, E. J, MACDONALD, K, BARKER, R. A, SCAHILL, R. I, FOX, N. C, TABRIZI, S. J

“…Longitudinal MR imaging measures provide an opportunity to track progression in HD before the emergence of clinical symptoms. This may prove useful in…”
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The differential diagnosis of chorea by Wild, E J, Tabrizi, S J

“…Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In…”
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Predictors for a dementia gene mutation based on gene-panel next-generation sequencing of a large dementia referral series by Koriath, C., Kenny, J., Adamson, G., Druyeh, R., Taylor, W., Beck, J., Quinn, L., Mok, T. H., Dimitriadis, A., Norsworthy, P., Bass, N., Carter, J., Walker, Z., Kipps, C., Coulthard, E., Polke, J. M., Bernal-Quiros, M., Denning, N., Thomas, R., Raybould, R., Williams, J., Mummery, C. J., Wild, E. J., Houlden, H., Tabrizi, S. J., Rossor, M. N., Hummerich, H., Warren, J. D., Rowe, J. B., Rohrer, J. D., Schott, J. M., Fox, N. C., Collinge, J., Mead, S.

“…Next-generation genetic sequencing (NGS) technologies facilitate the screening of multiple genes linked to neurodegenerative dementia, but there are few…”
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Relationship between CAG repeat length and brain volume in premanifest and early Huntington’s disease by Henley, S. M. D., Wild, E. J., Hobbs, N. Z., Scahill, R. I., Ridgway, G. R., MacManus, D. G., Barker, R. A., Fox, N. C., Tabrizi, S. J.

“…Huntington’s disease (HD) is caused by an expanded CAG repeat on the gene encoding for the protein huntingtin. There are conflicting findings about the extent…”
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F06 A critical evaluation of inflammatory markers in Huntington's disease plasma by Silajdžić, E, Lahiri, N, Wild, EJ, Tabrizi, SJ, Björkqvist, M

“…BackgroundHuntington's Disease (HD) is a progressive neurodegenerative genetic disorder characterised by motor dysfunction, cognitive decline and psychiatric…”
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Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis by Byrne, Lauren M, MRes, Rodrigues, Filipe B, MD, Blennow, Kaj, Prof, Durr, Alexandra, Prof, Leavitt, Blair R, Prof, Roos, Raymund A C, Prof, Scahill, Rachael I, PhD, Tabrizi, Sarah J, Prof, Zetterberg, Henrik, Prof, Langbehn, Douglas, Prof, Wild, Edward J, Dr

“…Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We…”
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Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington?s disease Young Adult Study (HD-YAS): a cross-sectional analysis by Scahill, R. I., Zeun, P., Osborne-Crowley, K., Johnson, E. B., Gregory, S., Parker, C., Lowe, J., Nair, A., O'Callaghan, C., Langley, C., Papoutsi, M., McColgan, P., Estevez-Fraga, C., Fayer, K., Wellington, H., Rodrigues, F. B., Byrne, L. M., Heselgrave, A., Hyare, H., Sampaio, C., Zetterberg, Henrik, Zhang, H., Wild, E. J., Rees, G., Robbins, T. W., Sahakian, B. J., Langbehn, D., Tabrizi, S. J.

“…Background Disease-modifying treatments are in development for Huntington's disease; crucial to their success is to identify a timepoint in a patient's life…”
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Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease by Byrne, Lauren M, Rodrigues, Filipe B, Johnson, Eileanor B, Wijeratne, Peter A, De Vita, Enrico, Alexander, Daniel C, Palermo, Giuseppe, Czech, Christian, Schobel, Scott, Scahill, Rachael I, Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J

“…Huntington's disease (HD) is a genetic progressive neurodegenerative disorder, caused by a mutation in the gene, for which there is currently no cure. The…”
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Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease by Rodrigues, Filipe B, Byrne, Lauren M, Tortelli, Rosanna, Johnson, Eileanoir B, Wijeratne, Peter A, Arridge, Marzena, De Vita, Enrico, Ghazaleh, Naghmeh, Houghton, Richard, Furby, Hannah, Alexander, Daniel C, Tabrizi, Sarah J, Schobel, Scott, Scahill, Rachael I, Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J

“…The longitudinal dynamics of the most promising biofluid biomarker candidates for Huntington's disease (HD)-mutant huntingtin (mHTT) and neurofilament light…”
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Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington’s disease R6/2 mice by Soylu-Kucharz, Rana, Sandelius, Åsa, Sjögren, Marie, Blennow, Kaj, Wild, Edward J., Zetterberg, Henrik, Björkqvist, Maria

“…There is an unmet need to reliably and non-invasively monitor disease progression in preclinical Huntington’s disease (HD) models. As a marker of axonal…”
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Enhanced near-infrared response of a-Si:H solar cells with β-NaYF4:Yb3+ (18%), Er3+ (2%) upconversion phosphors by DE WILD, J, RATH, J. K, MEIJERINK, A, VAN SARK, W. G. J. H. M, SCHROPP, R. E. I

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Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease by Rodrigues, Filipe Brogueira, Byrne, Lauren, McColgan, Peter, Robertson, Nicola, Tabrizi, Sarah J., Leavitt, Blair R., Zetterberg, Henrik, Wild, Edward J.

“…Huntington's disease (HD) is a hereditary neurodegenerative condition with no therapeutic intervention known to alter disease progression, but several trials…”
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Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease by Rodrigues, Filipe Brogueira, Byrne, Lauren M, McColgan, Peter, Robertson, Nicola, Tabrizi, Sarah J, Zetterberg, Henrik, Wild, Edward J

“…Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and…”
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Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease by Lowe, Alexander J, Sjödin, Simon, Rodrigues, Filipe B, Byrne, Lauren M, Blennow, Kaj, Tortelli, Rosanna, Zetterberg, Henrik, Wild, Edward J

“…Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo. The…”
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Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease by Byrne, Lauren M., Rodrigues, Filipe B., Johnson, Eileanoir B., De Vita, Enrico, Blennow, Kaj, Scahill, Rachael, Zetterberg, Henrik, Heslegrave, Amanda, Wild, Edward J.

“…Biomarkers of Huntington’s disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as…”
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The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study by Hobbs, Nicola Z, Henley, Susie M D, Ridgway, Gerard R, Wild, Edward J, Barker, Roger A, Scahill, Rachael I, Barnes, Josephine, Fox, Nick C, Tabrizi, Sarah J

“…BackgroundUnbiased longitudinal studies are needed to understand the distributed neurodegenerative changes of Huntington's disease (HD). They may also provide…”
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A BIBLIOGRAPHY OF RECENT PUBLICATIONS by Wild, J. E.

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F06A critical evaluation of inflammatory markers in Huntington's disease plasma by Silajdzic, E, Lahiri, N, Wild, E J, Tabrizi, S J, Bjorkqvist, M

“…BackgroundHuntington's Disease (HD) is a progressive neurodegenerative genetic disorder characterised by motor dysfunction, cognitive decline and psychiatric…”
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Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease by AZIZ, N. A, JURGENS, C. K, LANDWEHRMEYER, G. B, VAN ROON-MOM, W. M. C, VAN OMMEN, G. J. B, STIJNEN, T, ROOS, R. A. C

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in the HD gene (HTT). We aimed to assess whether…”
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Longitudinal evaluation of proton magnetic resonance spectroscopy metabolites as biomarkers in Huntington’s disease by Lowe, Alexander J, Rodrigues, Filipe B, Arridge, Marzena, De Vita, Enrico, Johnson, Eileanoir B, Scahill, Rachael I, Byrne, Lauren M, Tortelli, Rosanna, Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J

“…Abstract Proton magnetic resonance spectroscopy is a non-invasive method of exploring cerebral metabolism. In Huntington’s disease, altered proton magnetic…”
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