Search Results - "Wikström, Håkan V."

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions by Jurva, Ulrik, Wikström, Håkan V., Weidolf, Lars, Bruins, Andries P.

“…The extent to which electrochemistry on‐line with electrospray mass spectrometry can be used to mimic cytochrome P450 catalyzed oxidations has been…”
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Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: A comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride by Seneca, Nicholas, Finnema, Sjoerd J., Farde, Lars, Gulyás, Balázs, Wikström, Håkan V., Halldin, Christer, Innis, Robert B.

“…PET measurements of stimulant‐induced dopamine (DA) release are typically performed with antagonist radioligands that bind to both the high‐ and low‐affinity…”
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Novel 5-HT7 Receptor Inverse Agonists. Synthesis and Molecular Modeling of Arylpiperazine- and 1,2,3,4-Tetrahydroisoquinoline-Based Arylsulfonamides by Vermeulen, Erik S, van Smeden, Marjan, Schmidt, Anne W, Sprouse, Jeffrey S, Wikström, Håkan V, Grol, Cor J

“…A series of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides was synthesized and evaluated for their interactions with the…”
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A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey by Finnema, Sjoerd J, Seneca, Nicholas, Farde, Lars, Shchukin, Evgeny, Sóvágó, Judit, Gulyás, Balázs, Wikström, Håkan V, Innis, Robert B, Neumeyer, John L, Halldin, Christer

“…This study describes the preliminary positron emission tomography (PET) evaluation of a dopamine D(2)-like receptor agonist,…”
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A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist : 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol by DANYANG LIU, DIJKSTRA, Durk, DE VRIES, Jan B, WIKSTRÖM, Hakan V

“…Previously, we have demonstrated that enone prodrugs of dopaminergic catecholamines represent a new type of dopamine (DA) agonist…”
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Characterization of the 5-HT7 Receptor. Determination of the Pharmacophore for 5-HT7 Receptor Agonism and CoMFA-Based Modeling of the Agonist Binding Site by Vermeulen, Erik S, Schmidt, Anne W, Sprouse, Jeffrey S, Wikström, Håkan V, Grol, Cor J

“…On the basis of a set of 20 diverse 5-HT7 receptor agonists, the pharmacophore for 5-HT7 receptor agonism was determined. Additionally two CoMFA models were…”
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Extremely Potent Orally Active Benzo[g]quinoline Analogue of the Dopaminergic Prodrug:  6-(N,N-Di-n-propyl)amino-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one by Liu, Danyang, Wikström, Håkan V, Dijkstra, Durk, de Vries, Jan B, Venhuis, Bastiaan J

“…Enone prodrugs of dopaminergic catecholamines represent a new type of prodrug in the research area of dopamine agonists. Here, we demonstrate the first…”
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Synthesis and Pharmacological Testing of 1,2,3,4,10,14b-Hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and Its Enantiomers in Comparison with the Two Antidepressants Mianserin and Mirtazapine by Wikström, Håkan V, Mensonides-Harsema, Marguérite M, Cremers, Thomas I. F. H, Moltzen, Ejner K, Arnt, Jørn

“…The synthesis and resolution of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin (6-methoxymianserin, 6) are described…”
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Extremely Potent Orally Active Benzo[g]quinoline Analogue of the Dopaminergic Prodrug:  1-Propyl-trans-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo-[g]quinolin-6-one by Liu, Danyang, Wikström, Håkan V, Dijkstra, Durk, de Vries, Jan B, Venhuis, Bastiaan J

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Orally Active Oxime Derivatives of the Dopaminergic Prodrug 6-(N,N-Di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and Pharmacological Activity by Venhuis, Bastiaan J, Dijkstra, Durk, Wustrow, David, Meltzer, Len T, Wise, Lawrence D, Johnson, Stephen J, Wikström, Håkan V

“…A series of racemic and enantiomerically pure oxime derivatives of the potential anti-Parkinson prodrug…”
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Further Characterization of Structural Requirements for Ligands at the Dopamine D2 and D3 Receptor:  Exploring the Thiophene Moiety by Dijkstra, Durk, Rodenhuis, Nienke, Vermeulen, Erik S, Pugsley, Thomas A, Wise, Lawrence D, Wikström, Håkan V

“…The present study describes the synthesis and in vitro pharmacology of a novel series of dopaminergic agents in which the classical phenylethylamine…”
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Structure−Cytotoxicity Relationships of Some Helenanolide-Type Sesquiterpene Lactones by Beekman, Aäron C, Woerdenbag, Herman J, van Uden, Wim, Pras, Niesko, Konings, Antonius W. T, Wikström, Håkan V, Schmidt, Thomas J

“…This study deals with the cytotoxicity of helenanolide-type (10α-methylpseudoguaianolide) sesquiterpene lactones. We determined the influence of substitution…”
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A New Type of Prodrug of Catecholamines:  An Opportunity to Improve the Treatment of Parkinson's Disease by Venhuis, Bastiaan J, Wikström, Håkan V, Rodenhuis, Nienke, Sundell, Staffan, Dijkstra, Durk

“…After decades of research around dopamine agonists, we have found a promising compound in S-PD148903 that represents a new type of prodrug, which in the rat is…”
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Is the beneficial antidepressant effect of coadministration of pindolol really due to somatodendritic autoreceptor antagonism? by Cremers, Thomas I.F.H, Wiersma, Loes J, Bosker, Fokko J, den Boer, Johan A, Westerink, Ben H.C, Wikström, Håkan V

“…Background: We investigated the combination of selective serotonin reuptake inhibitors (SSRIs) with the β-adrenoceptor/serotonin 1A (5-HT1A) antagonist…”
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Orally Active Analogues of the Dopaminergic Prodrug 6-(N,N-Di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one:  Synthesis and Pharmacological Activity by Venhuis, Bastiaan J, Dijkstra, Durk, Wustrow, David J, Meltzer, Leonard T, Wise, Lawrence D, Johnson, Stephen J, Heffner, Thomas G, Wikström, Håkan V

“…A series of analogues of 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one (6), an enone prodrug of the mixed DA D1/D2 agonist 5,6-diOH-DPAT…”
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Inactivation of 5-HT2C receptors potentiates consequences of serotonin reuptake blockade by CREMERS, Thomas I. F. H, GIORGETTI, Marco, WIKSTROM, Hakan V, TECOTT, Lawrence H, BOSKER, Fokko J, HOGG, Sandra, ARNT, Jørn, MØRK, Arne, HONIG, Gerard, BØGESØ, Klaus-Peter, WESTERINK, Ben H. C, DEN BOER, Hans

“…The enhancement of central serotonin system function underlies the therapeutic effects of selective serotonin reuptake inhibitors (SSRIs), which have become…”
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Ion-pair formation of hydroquinine by chromatography by Marchais, Sandrine, Vermeulen, Erik S, Semple, Graeme, Sundell, Staffan, Wikström, Håkan V

“…The study of hydroquinine, a Cinchona alkaloid, by analytical TLC (silica gel) in a mixture of dichloromethane and methanol (9/1, v/v) has shown that a new…”
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Electrochemically assisted Fenton reaction: reaction of hydroxyl radicals with xenobiotics followed by on-line analysis with high-performance liquid chromatography/tandem mass spectrometry by Jurva, Ulrik, Wikström, Håkan V., Bruins, Andries P.

“…Oxygen radicals are generated in vivo by various processes, often as toxic intermediates in different metabolic transformations, and have been shown to play an…”
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N-Oxide analogs of WAY-100635: new high affinity 5-HT1A receptor antagonists by MARCHAIS-OBERWINKLER, Sandrine, NOWICKI, Bartek, PIKE, Victor W, HALLDIN, Christer, SANDELL, Johan, CHOU, Yuan-Hwa, GULYAS, Balazs, BRENNUM, Lise T, FARDE, Lars, WIKSTRÖM, Hakan V

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Stereochemistry-Dependent Cytotoxicity of Some Artemisinin Derivatives by Beekman, Aäron C, Barentsen, Adriaan R. W, Woerdenbag, Herman J, Van Uden, Wim, Pras, Niesko, Konings, Antonius W. T, El-Feraly, Farouk S, Galal, Ahmed M, Wikström, Håkan V

“…We determined the cytotoxicity of some artemisinin derivatives against EN2 tumor cells using the MTT assay. Artemisinin (1) was clearly more cytotoxic than…”
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