Search Results - "Wikoff, Daniele"

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    Benefit-risk of coffee consumption and all-cause mortality: A systematic review and disability adjusted life year analysis by Doepker, Candace, Movva, Naimisha, Cohen, Sarah S., Wikoff, Daniele S.

    Published in Food and chemical toxicology (01-12-2022)
    “…Recommendations and guidance from scientific bodies do not provide clear messages about potential health risks or benefits of coffee consumption. Numerous…”
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    Assessment of Mechanistic Data for Hexavalent Chromium-Induced Rodent Intestinal Cancer Using the Key Characteristics of Carcinogens by Chappell, Grace A, Wikoff, Daniele S, Thompson, Chad M

    Published in Toxicological sciences (26-02-2021)
    “…Abstract Oral exposure to hexavalent chromium (Cr[VI]) induces intestinal tumors in mice. Mutagenic and nonmutagenic modes of action (MOAs) have been accepted…”
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    Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence by Lea, Isabel A., Chappell, Grace A., Wikoff, Daniele S.

    “…•The safety of low- and no- calorie sweeteners is frequently revisited.•Genotoxicity potential of five common LNCS was surveyed and summarized.•Peer-review…”
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    Assessing the food safety risk of ochratoxin A in coffee: A toxicology‐based approach to food safety planning by Heintz, Melissa M., Doepker, Candace L., Wikoff, Daniele S., Hawks, Scott E.

    Published in Journal of food science (01-11-2021)
    “…Under the Food Safety Modernization Act (FSMA) and preventive controls (PCs) regulations, food manufacturers must consider whether PCs are needed for potential…”
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    Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects by Urban, Jonathan D., Wikoff, Daniele S., Chappell, Grace A., Harris, Craig, Haws, Laurie C.

    Published in Toxicology (Amsterdam) (30-04-2020)
    “…The hypothesis that in utero exposures to low levels of trichloroethylene (TCE) may increase the risk of congenital heart defects (CHDs) in offspring remains a…”
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    A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens by Wikoff, Daniele S, Rager, Julia E, Chappell, Grace A, Fitch, Seneca, Haws, Laurie, Borghoff, Susan J

    Published in Toxicological sciences (01-02-2019)
    “…Abstract Recently, the key characteristics of carcinogens (KCC) have been proposed as an organizational approach for the evaluation of mechanistic data related…”
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    Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005–2006 and 2007–2008: A multiple imputation and trending approach incorporating NHANES pooled sample data by Bichteler, Anne, Wikoff, Daniele S., Loko, Francis, Harris, Mark A.

    Published in Environment international (01-08-2017)
    “…Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES)…”
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    Safety evaluation of 8 drug degradants present in over-the-counter cough and cold medications by Mihalchik, Amy L., Choksi, Neepa Y., Roe, Amy L., Wisser, Michael, Whitaker, Kylen, Seibert, Donna, Deore, Milind, Pavlick, Larisa, Wikoff, Daniele S.

    Published in Regulatory toxicology and pharmacology (01-05-2024)
    “…Although the United States Food & Drug Administration (FDA) has provided guidance on the control of drug degradants for prescription drugs, there is less…”
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    Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): a systematic map by Fitch, Seneca E, Payne, Lauren E, van de Ligt, Jennifer L G, Doepker, Candace, Handu, Deepa, Cohen, Samuel M, Anyangwe, Njwen, Wikoff, Daniele

    Published in BMC public health (20-05-2021)
    “…It is well-recognized that consumers face many challenges in understanding and applying nutritional guidance for low-calorie sweeteners (LCS). Thus, this…”
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    Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations by Thompson, Chad M., Suh, Mina, Mittal, Liz, Wikoff, Daniele S., Welsh, Brian, Proctor, Deborah M.

    Published in Regulatory toxicology and pharmacology (01-10-2016)
    “…Titanium dioxide (TiO2) has been characterized as a poorly soluble particulate (PSP) with low toxicity. It is well accepted that low toxicity PSPs such as TiO2…”
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