Search Results - "Wiklander, P.B. Oscar"

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging by Gupta, Dhanu, Liang, Xiuming, Pavlova, Svetlana, Wiklander, Oscar P.B, Corso, Giulia, Zhao, Ying, Saher, Osama, Bost, Jeremy, Zickler, Antje M., Piffko, Andras, Maire, Cecile L., Ricklefs, Franz L., Gustafsson, Oskar, Llorente, Virginia Castilla, Gustafsson, Manuela O., Bostancioglu, R. Beklem, Mamand, Doste R, Hagey, Daniel W., Görgens, André, Nordin, Joel Z., EL Andaloussi, Samir

“…Extracellular vesicles (EVs) are naturally occurring nano-sized carriers that are secreted by cells and facilitate cell-to-cell communication by their unique…”
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RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form by Rocha, Cristina S.J, Wiklander, Oscar P.B, Larsson, Lilian, Moreno, Pedro M.D, Parini, Paolo, Lundin, Karin E, Smith, C.I. Edvard

“…Abstract Hypercholesterolemia is a medical condition often characterized by high levels of low-density lipoprotein cholesterol (LDL-C) in the blood. Despite…”
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Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging by Corso, Giulia, Heusermann, Wolf, Trojer, Dominic, Görgens, André, Steib, Emmanuelle, Voshol, Johannes, Graff, Alexandra, Genoud, Christel, Lee, Yi, Hean, Justin, Nordin, Joel Z., Wiklander, Oscar P.B., El Andaloussi, Samir, Meisner-Kober, Nicole

“…Extracellular vesicles (EV) convey biological information by transmitting macromolecules between cells and tissues and are of great promise as pharmaceutical…”
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Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties by Nordin, Joel Z., M.D, Lee, Yi, BSc, Vader, Pieter, PhD, Mäger, Imre, PhD, Johansson, Henrik J., PhD, Heusermann, Wolf, PhD, Wiklander, Oscar P.B., M.D, Hällbrink, Mattias, PhD, Seow, Yiqi, DPhil, Bultema, Jarred J., PhD, Gilthorpe, Jonathan, PhD, Davies, Tim, MSc, Fairchild, Paul J., PhD, Gabrielsson, Susanne, PhD, Meisner-Kober, Nicole C., PhD, Lehtiö, Janne, PhD, Smith, C.I. Edvard, M.D., PhD, Wood, Matthew J.A., M.D., DPhil, Andaloussi, Samir EL, PhD

“…Abstract Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of RNA and proteins and are of great medical interest;…”
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Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome by Sork, Helena, Corso, Giulia, Krjutskov, Kaarel, Johansson, Henrik J., Nordin, Joel Z., Wiklander, Oscar P. B., Lee, Yi Xin Fiona, Westholm, Jakub Orzechowski, Lehtiö, Janne, Wood, Matthew J. A., Mäger, Imre, EL Andaloussi, Samir

“…Extracellular vesicles (EVs) mediate cell-to-cell communication by delivering or displaying macromolecules to their recipient cells. While certain…”
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G-CSF-induced aortitis: Two cases and review of the literature by Parodis, Ioannis, Dani, Lara, Notarnicola, Antonella, Martenhed, Git, Fernström, Pontus, Matikas, Alexios, Wiklander, Oscar P.B.

“…Febrile neutropenia is generally recognised as a complication of myelosuppressive chemotherapy. Recombinant human granulocyte colony stimulating factor (G-CSF)…”
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Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice by Berger, Emmanuelle, Colosetti, Pascal, Jalabert, Audrey, Meugnier, Emmanuelle, Wiklander, Oscar P.B., Jouhet, Juliette, Errazurig-Cerda, Elisabeth, Chanon, Stéphanie, Gupta, Dhanu, Rautureau, Gilles J.P., Geloen, Alain, El-Andaloussi, Samir, Panthu, Baptiste, Rieusset, Jennifer, Rome, Sophie

“…We have determined whether orange juice-derived nanovesicles (ONVs) could be used for the treatment of obesity-associated intestinal complications. ONVs were…”
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Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia

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Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models by Liang, Xiuming, Niu, Zheyu, Galli, Valentina, Howe, Nathalie, Zhao, Ying, Wiklander, Oscar P. B., Zheng, Wenyi, Wiklander, Rim Jawad, Corso, Giulia, Davies, Christopher, Hean, Justin, Kyriakopoulou, Eleni, Mamand, Doste R., Amin, Risul, Nordin, Joel Z., Gupta, Dhanu, Andaloussi, Samir EL

“…Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after…”
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Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute Respiratory Distress Syndrome by Jungebluth, Philipp, Holzgraefe, Bernhard, Lim, Mei Ling, Duru, Adil Doganay, Lundin, Vanessa, Heldring, Nina, Wiklander, Oscar P B, Nordin, Joel Z, Chrobok, Michael, Roderburg, Christoph, Sjöqvist, Sebastian, Anderstam, Björn, Beltrán Rodríguez, Antonio, Haag, Johannes C, Gustafsson, Ylva, Roddewig, Katharina G, Jones, Petra, Wood, Matthew J A, Luedde, Tom, Teixeira, Ana I, Hermanson, Ola, Winqvist, Ola, Kalzén, Håkan, El Andaloussi, Samir, Alici, Evren, Macchiarini, Paolo

“…Acute respiratory distress syndrome (ARDS) is a devastating disorder. Despite enormous efforts in clinical research, effective treatment options are lacking,…”
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Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle by Katayama, Mutsumi, Wiklander, Oscar P B, Fritz, Tomas, Caidahl, Kenneth, El-Andaloussi, Samir, Zierath, Juleen R, Krook, Anna

“…miRNAs are noncoding RNAs representing an important class of gene expression modulators. Extracellular circulating miRNAs are both candidate biomarkers for…”
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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al‐Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El‐Andaloussi, Samir, Alvarez‐Erviti, Lydia

“…ABSTRACT Alpha‐synuclein (α‐Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson's disease…”
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Identification of storage conditions stabilizing extracellular vesicles preparations by Görgens, André, Corso, Giulia, Hagey, Daniel W., Jawad Wiklander, Rim, Gustafsson, Manuela O., Felldin, Ulrika, Lee, Yi, Bostancioglu, R. Beklem, Sork, Helena, Liang, Xiuming, Zheng, Wenyi, Mohammad, Dara K., van de Wakker, Simonides I., Vader, Pieter, Zickler, Antje M., Mamand, Doste R., Ma, Li, Holme, Margaret N., Stevens, Molly M., Wiklander, Oscar P. B., EL Andaloussi, Samir

“…Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological processes and hold great potential for therapeutic and diagnostic…”
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Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures by Wiklander, Oscar P B, Bostancioglu, R Beklem, Welsh, Joshua A, Zickler, Antje M, Murke, Florian, Corso, Giulia, Felldin, Ulrika, Hagey, Daniel W, Evertsson, Björn, Liang, Xiu-Ming, Gustafsson, Manuela O, Mohammad, Dara K, Wiek, Constanze, Hanenberg, Helmut, Bremer, Michel, Gupta, Dhanu, Björnstedt, Mikael, Giebel, Bernd, Nordin, Joel Z, Jones, Jennifer C, El Andaloussi, Samir, Görgens, André

“…Extracellular vesicles (EVs) can be harvested from cell culture supernatants and from all body fluids. EVs can be conceptually classified based on their size…”
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Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle by Conceição, Mariana, Forcina, Laura, Wiklander, Oscar P.B., Gupta, Dhanu, Nordin, Joel Z., Vrellaku, Besarte, McClorey, Graham, Mäger, Imre, Gӧrgens, André, Lundin, Per, Musarò, Antonio, Wood, Matthew J.A., Andaloussi, Samir EL, Roberts, Thomas C.

“…The cytokine interleukin 6 (IL6) is a key mediator of inflammation that contributes to skeletal muscle pathophysiology. IL6 activates target cells by two main…”
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Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin by Lennaárd, Angus J, Mamand, Doste R, Wiklander, Rim Jawad, El Andaloussi, Samir, Wiklander, Oscar P B

“…The clinical use of chemotherapeutics is limited by several factors, including low cellular uptake, short circulation time, and severe adverse effects…”
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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting by Wiklander, Oscar P. B., Nordin, Joel Z., O'Loughlin, Aisling, Gustafsson, Ylva, Corso, Giulia, Mäger, Imre, Vader, Pieter, Lee, Yi, Sork, Helena, Seow, Yiqi, Heldring, Nina, Alvarez-Erviti, Lydia, Smith, CI Edvard, Le Blanc, Katarina, Macchiarini, Paolo, Jungebluth, Philipp, Wood, Matthew J. A., Andaloussi, Samir EL

“…Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in a diverse range of biological processes. For future…”
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Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice by Aswad, Hala, Forterre, Alexis, Wiklander, Oscar P. B., Vial, Guillaume, Danty-Berger, Emmanuelle, Jalabert, Audrey, Lamazière, Antonin, Meugnier, Emmanuelle, Pesenti, Sandra, Ott, Catherine, Chikh, Karim, El-Andaloussi, Samir, Vidal, Hubert, Lefai, Etienne, Rieusset, Jennifer, Rome, Sophie

“…Aims/hypothesis Exosomes released from cells can transfer both functional proteins and RNAs between cells. In this study we tested the hypothesis that muscle…”
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Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase by Mamand, Doste R, Bazaz, Safa, Mohammad, Dara K., Saher, Osama, Wiklander, Oscar P.B., Sadeghi, Behnam, Hassan, Moustapha, EL-Andaloussi, Samir, Abedi-Valugerdi, Manuchehr

“…The immune escape stage in cancer immunoediting is a pivotal feature, transitioning immune-controlled tumor dormancy to progression, and augmenting invasion…”
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Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles by Zheng, Wenyi, Rädler, Julia, Sork, Helena, Niu, Zheyu, Roudi, Samantha, Bost, Jeremy P., Görgens, André, Zhao, Ying, Mamand, Doste R., Liang, Xiuming, Wiklander, Oscar P. B., Lehto, Taavi, Gupta, Dhanu, Nordin, Joel Z., EL Andaloussi, Samir

“…Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities. Genetic fusion of the protein of interest to a scaffold protein…”
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