Search Results - "Wijmeersch, Bart"
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Effects of an individual 12-week community-located “start-to-run” program on physical capacity, walking, fatigue, cognitive function, brain volumes, and structures in persons with multiple sclerosis
Published in Multiple sclerosis (01-01-2019)“…Background: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage, while cognitive…”
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2
Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression
Published in Frontiers in immunology (20-09-2017)“…Multiple sclerosis (MS) is the leading cause of chronic neurological disability in young adults. The clinical disease course of MS varies greatly between…”
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Machine learning analysis of motor evoked potential time series to predict disability progression in multiple sclerosis
Published in BMC neurology (21-03-2020)“…Evoked potentials (EPs) are a measure of the conductivity of the central nervous system. They are used to monitor disease progression of multiple sclerosis…”
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Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation
Published in Scientific reports (06-04-2017)“…Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4 +…”
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A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?
Published in Multiple sclerosis (01-10-2020)“…Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are…”
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Immune thrombocytopenia in alemtuzumab-treated MS patients: Incidence, detection, and management
Published in Multiple sclerosis (01-01-2020)“…Background: Alemtuzumab is a highly effective therapy for relapsing-remitting multiple sclerosis (RRMS), and immune thrombocytopenia (ITP) has been identified…”
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7
Differential effects and discriminative validity of motor and cognitive tasks varying in difficulty on cognitive–motor interference in persons with multiple sclerosis
Published in Multiple sclerosis (01-10-2021)“…Background: Cognitive–motor interference (CMI) has been well recognized in persons with multiple sclerosis (pwMS); however, there are limited data on effects…”
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Motor evoked potentials for multiple sclerosis, a multiyear follow-up dataset
Published in Scientific data (16-05-2022)“…Multiple sclerosis (MS) is a chronic disease affecting millions of people worldwide. Through the demyelinating and axonal pathology of MS, the signal…”
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Documenting outdoor activity and travel behaviour in persons with neurological conditions using travel diaries and GPS tracking technology: a pilot study in multiple sclerosis
Published in Disability and rehabilitation (01-09-2013)“…Abstract Objective: Persons with multiple sclerosis (PwMS) experience several physical and cognitive problems which can influence their travel behaviour. This…”
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10
Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs
Published in JCI insight (08-04-2024)“…In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune…”
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Clinical manifestation and perceived symptoms of walking-related performance fatigability in persons with multiple sclerosis
Published in International journal of rehabilitation research (01-06-2021)“…Fatigue and walking difficulties are common impairments and activity limitations in persons with multiple sclerosis (PwMS). Walking fatigability (WF) can be…”
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Efficacy of alemtuzumab over 6 years in relapsing–remitting multiple sclerosis patients who relapsed between courses 1 and 2: Post hoc analysis of the CARE-MS studies
Published in Multiple sclerosis (01-11-2020)“…Background: Alemtuzumab is administered as two annual courses for relapsing–remitting multiple sclerosis (MS). Patients may relapse before completing the…”
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Prediction of on-treatment disability worsening in RRMS with the MAGNIMS score
Published in Multiple sclerosis (01-04-2021)“…Background: The magnetic resonance imaging in multiple sclerosis (MAGNIMS) score combines relapses and magnetic resonance imaging (MRI) lesions to predict…”
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14
Multidisciplinary data infrastructures in multiple sclerosis: Why they are needed and can be done
Published in Multiple Sclerosis Journal (01-04-2019)“…Personalized treatment is highly desirable in multiple sclerosis (MS). We believe that multidisciplinary measurements including clinical, functional and…”
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Book Review Journal Article -
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Efficacy and safety of ocrelizumab in patients with relapsing‐remitting multiple sclerosis with suboptimal response to prior disease‐modifying therapies: A primary analysis from the phase 3b CASTING single‐arm, open‐label trial
Published in European journal of neurology (01-03-2022)“…Background and purpose Using the treatment goal of “no evidence of disease activity” (NEDA) incorporating magnetic resonance imaging (MRI) re‐baselining, we…”
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Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis
Published in Neuroscience letters (25-10-2013)“…•The effect of anodal tDCS on corticospinal excitability was evaluated in MS-patients.•A single session of 20min anodal tDCS was applied to the M1…”
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Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study
Published in PloS one (31-10-2014)“…The long term effects of fingolimod, an oral treatment for relapsing-remitting (RR) multiple sclerosis (MS), on blood circulating B and T cell subtypes in MS…”
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Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis
Published in Journal of neurology, neurosurgery and psychiatry (01-04-2019)“…ObjectiveOral immunotherapies have become a standard treatment in relapsing-remitting multiple sclerosis. Direct comparison of their effect on relapse and…”
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Best Practices for Long-Term Monitoring and Follow-Up of Alemtuzumab-Treated MS Patients in Real-World Clinical Settings
Published in Frontiers in neurology (22-03-2019)“…Multiple sclerosis (MS) is a chronic autoimmune neurological disease that typically affects young adults, causing irreversible physical disability and…”
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Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors
Published in Multiple sclerosis (01-04-2014)“…Background: The role of the adaptive immune system and more specifically T cells in the pathogenesis of multiple sclerosis (MS) has been studied extensively…”
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