Search Results - "Wijkhuijs, Annemarie J.M."

Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Mazza, Elena, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Bollettini, Irene, Colombo, Cristina, Arolt, Volker, Drexhage, Hemmo A

“…Abstract Background Bipolar disorder (BD) is associated with elevated biomarkers of cell-mediated immune activation and inflammation and with signs of…”
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Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls by Poletti, Sara, de Wit, Harm, Mazza, Elena, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Aggio, Veronica, Colombo, Cristina, Benedetti, Francesco, Drexhage, Hemmo A

“…Highlights • Frequency of Th17 correlated to higher coherence of white matter microstructure. • Frequency of T regulatory cells correlated to a reduced…”
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Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder by Grosse, Laura, Carvalho, Livia A, Wijkhuijs, Annemarie J.M, Bellingrath, Silja, Ruland, Tillmann, Ambrée, Oliver, Alferink, Judith, Ehring, Thomas, Drexhage, Hemmo A, Arolt, Volker

“…Abstract Increased inflammatory activation might only be present in a subgroup of depressed individuals in which immune processes are especially relevant to…”
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Correlation between nivolumab exposure and treatment outcomes in non–small-cell lung cancer by Basak, Edwin A., Koolen, Stijn L.W., Hurkmans, Daan P., Schreurs, Marco W.J., Bins, Sander, Oomen – de Hoop, Esther, Wijkhuijs, Annemarie J.M., Besten, Ilse den, Sleijfer, Stefan, Debets, Reno, van der Veldt, Astrid A.M., Aerts, Joachim G.J.V., Mathijssen, Ron H.J.

“…Nivolumab treatment is subject to large interpatient variability in both efficacy and toxicity, which may partly be explained by differences in nivolumab…”
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Prospective real-world study on the pharmacokinetics of pembrolizumab in patients with solid tumors by Hurkmans, Daan P., Sassen, Sebastiaan D.T., de Joode, Karlijn, Putter, Lisanne, Basak, Edwin A., Wijkhuijs, Annemarie J.M., Joerger, Markus, Debets, Reno, Koch, Birgit C.P., Van der Leest, Cor H., Schreurs, Marco W.J., van der Veldt, Astrid A.M., Aerts, Joachim G.J.V., Mathijssen, Ron H.J., Koolen, Stijn L.W.

“…BackgroundDosing schemes of pembrolizumab (anti-programmed cell death protein 1 monoclonal antibody) are solely based on pharmacokinetic (PK) modelling derived…”
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Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Locatelli, Clara, de Wit, Harm, Wijkhuijs, Annemarie J M, Colombo, Cristina, Drexhage, Hemmo A

“…The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity,…”
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Markers of neuroinflammation influence measures of cortical thickness in bipolar depression by Poletti, Sara, Leone, Giovanni, Hoogenboezem, Thomas A., Ghiglino, Davide, Vai, Benedetta, de Wit, Harm, Wijkhuijs, Annemarie J.M., Locatelli, Clara, Colombo, Cristina, Drexhage, Hemmo A., Benedetti, Francesco

“…•Serum levels of ICAM-1, CCL4, sDC25 correlated with lower cortical thickness.•Serum levels of TNF-α, IL-8, and CCL2 correlated with a higher cortical…”
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Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity by Berentschot, Julia C., Drexhage, Hemmo A., Aynekulu Mersha, Daniel G., Wijkhuijs, Annemarie J. M., GeurtsvanKessel, Corine H., Koopmans, Marion P. G., Voermans, Jolanda J. C., Hendriks, Rudi W., Nagtzaam, Nicole M. A., de Bie, Maaike, Heijenbrok-Kal, Majanka H., Bek, L. Martine, Ribbers, Gerard M., van den Berg-Emons, Rita J. G., Aerts, Joachim G. J. V., Dik, Willem A., Hellemons, Merel E.

“…Background Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling symptoms. We performed clinical and immune…”
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Effect of an inhaled glucocorticoid on reactive oxygen species production by bronchoalveolar lavage cells from smoking COPD patients by Verhoeven, G T, Wijkhuijs, A J, Hooijkaas, H, Hoogsteden, H C, Sluiter, W

“…OXIDATIVE stress in the lung is important in the pathogenesis of COPD. Published data indicate that glucocorticoids inhibit blood cells in their capacity to…”
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Development of an Enzyme-Linked Immune Sorbent Assay to Measure Nivolumab and Pembrolizumab Serum Concentrations by Basak, Edwin A, Wijkhuijs, Annemarie J M, Mathijssen, Ron H J, Koolen, Stijn L W, Schreurs, Marco W J

“…Treatment with monoclonal antibodies (mAbs) against programmed cell death protein 1 receptor is subject to high variation in treatment outcome among cancer…”
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A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients by Hurkmans, Daan P, Basak, Edwin A, van Dijk, Tanja, Mercieca, Darlene, Schreurs, Marco W J, Wijkhuijs, Annemarie J M, Bins, Sander, Hoop, Esther Oomen-de, Debets, Reno, Joerger, Markus, Odink, Arlette, van der Veldt, Astrid A M, van der Leest, Cor H, Aerts, Joachim G J V, Mathijssen, Ron H J, Koolen, Stijn L W

“…Nivolumab is administered in a weight-based or fixed-flat dosing regimen. For patients with non-small cell lung cancer (NSCLC), a potential exposure-response…”
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Stem Cell Factor (SCF) is a putative biomarker of antidepressant response by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A., Locatelli, Clara, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J. M., Mazza, Elena, Bulgarelli, Chiara, Vai, Benedetta, Colombo, Cristina, Smeraldi, Enrico, Arolt, Volker, Drexhage, Hemmo A.

“…Growth factors involved in neurogenesis and neuroplasticity could play a role in biological processes that drive depression recovery. Combined total sleep…”
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Fatigue in Sjögren's Syndrome: A Search for Biomarkers and Treatment Targets by Bodewes, Iris L A, van der Spek, Peter J, Leon, Leticia G, Wijkhuijs, Annemarie J M, van Helden-Meeuwsen, Cornelia G, Tas, Liselotte, Schreurs, Marco W J, van Daele, Paul L A, Katsikis, Peter D, Versnel, Marjan A

“…Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, where patients often suffer from fatigue. Biological pathways underlying fatigue are…”
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Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage by Szczepański, Tomasz, Pongers-Willemse, Marja J., Langerak, Anton W., Harts, Wietske A., Wijkhuijs, Annemarie J.M., van Wering, Elisabeth R., van Dongen, Jacques J.M.

“…Rearranged IGH genes were detected by Southern blotting in 22% of 118 cases of T-cell acute lymphoblastic leukemia (ALL) and involved monoallelic and biallelic…”
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Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage by Szczepański, Tomasz, Pongers-Willemse, Marja J., Langerak, Anton W., Harts, Wietske A., Wijkhuijs, Annemarie J.M., van Wering, Elisabeth R., van Dongen, Jacques J.M.

“…Abstract Rearranged IGH genes were detected by Southern blotting in 22% of 118 cases of T-cell acute lymphoblastic leukemia (ALL) and involved monoallelic and…”
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Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder: A Twin Study by Padmos, Roos C, Van Baal, G. Caroline M, Vonk, Ronald, Wijkhuijs, Annemarie J. M, Kahn, René S, Nolen, Willem A, Drexhage, Hemmo A

“…CONTEXT A monocyte pro-inflammatory state has previously been reported in bipolar disorder (BD). OBJECTIVE To determine the contribution of genetic and…”
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Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor αβ Lineage by Szczepański, Tomasz, Pongers-Willemse, Marja J., Langerak, Anton W., Harts, Wietske A., Wijkhuijs, Annemarie J.M., van Wering, Elisabeth R., van Dongen, Jacques J.M.

“…Rearranged IGH genes were detected by Southern blotting in 22% of 118 cases of T-cell acute lymphoblastic leukemia (ALL) and involved monoallelic and biallelic…”
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