Search Results - "Wijkhuijs, Annemarie"

Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Mazza, Elena, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Bollettini, Irene, Colombo, Cristina, Arolt, Volker, Drexhage, Hemmo A

“…Abstract Background Bipolar disorder (BD) is associated with elevated biomarkers of cell-mediated immune activation and inflammation and with signs of…”
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Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls by Poletti, Sara, de Wit, Harm, Mazza, Elena, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Aggio, Veronica, Colombo, Cristina, Benedetti, Francesco, Drexhage, Hemmo A

“…Highlights • Frequency of Th17 correlated to higher coherence of white matter microstructure. • Frequency of T regulatory cells correlated to a reduced…”
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Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder by Grosse, Laura, Carvalho, Livia A, Wijkhuijs, Annemarie J.M, Bellingrath, Silja, Ruland, Tillmann, Ambrée, Oliver, Alferink, Judith, Ehring, Thomas, Drexhage, Hemmo A, Arolt, Volker

“…Abstract Increased inflammatory activation might only be present in a subgroup of depressed individuals in which immune processes are especially relevant to…”
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Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Locatelli, Clara, de Wit, Harm, Wijkhuijs, Annemarie J M, Colombo, Cristina, Drexhage, Hemmo A

“…The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity,…”
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Markers of neuroinflammation influence measures of cortical thickness in bipolar depression by Poletti, Sara, Leone, Giovanni, Hoogenboezem, Thomas A., Ghiglino, Davide, Vai, Benedetta, de Wit, Harm, Wijkhuijs, Annemarie J.M., Locatelli, Clara, Colombo, Cristina, Drexhage, Hemmo A., Benedetti, Francesco

“…•Serum levels of ICAM-1, CCL4, sDC25 correlated with lower cortical thickness.•Serum levels of TNF-α, IL-8, and CCL2 correlated with a higher cortical…”
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Correlation between nivolumab exposure and treatment outcomes in non–small-cell lung cancer by Basak, Edwin A., Koolen, Stijn L.W., Hurkmans, Daan P., Schreurs, Marco W.J., Bins, Sander, Oomen – de Hoop, Esther, Wijkhuijs, Annemarie J.M., Besten, Ilse den, Sleijfer, Stefan, Debets, Reno, van der Veldt, Astrid A.M., Aerts, Joachim G.J.V., Mathijssen, Ron H.J.

“…Nivolumab treatment is subject to large interpatient variability in both efficacy and toxicity, which may partly be explained by differences in nivolumab…”
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Deficiencies of the T and natural killer cell system in major depressive disorder by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…Highlights • Lymphocyte subsets were analyzed in major depressive disorder (MDD) patients. • NK cells, Th-2 cells, and Th-17 cells were reduced in MDD…”
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Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium by Arteaga-Henríquez, Gara, Simon, Maria S, Burger, Bianka, Weidinger, Elif, Wijkhuijs, Annemarie, Arolt, Volker, Birkenhager, Tom K, Musil, Richard, Müller, Norbert, Drexhage, Hemmo A

“…Low-grade inflammation plays a role not only in the pathogenesis of major depressive disorder (MDD) but probably also in the poor responsiveness to regular…”
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Stem Cell Factor (SCF) is a putative biomarker of antidepressant response by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A., Locatelli, Clara, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J. M., Mazza, Elena, Bulgarelli, Chiara, Vai, Benedetta, Colombo, Cristina, Smeraldi, Enrico, Arolt, Volker, Drexhage, Hemmo A.

“…Growth factors involved in neurogenesis and neuroplasticity could play a role in biological processes that drive depression recovery. Combined total sleep…”
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Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a…”
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A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients by Hurkmans, Daan P, Basak, Edwin A, van Dijk, Tanja, Mercieca, Darlene, Schreurs, Marco W J, Wijkhuijs, Annemarie J M, Bins, Sander, Hoop, Esther Oomen-de, Debets, Reno, Joerger, Markus, Odink, Arlette, van der Veldt, Astrid A M, van der Leest, Cor H, Aerts, Joachim G J V, Mathijssen, Ron H J, Koolen, Stijn L W

“…Nivolumab is administered in a weight-based or fixed-flat dosing regimen. For patients with non-small cell lung cancer (NSCLC), a potential exposure-response…”
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Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression by Schiweck, Carmen, Claes, Stephan, Van Oudenhove, Lukas, Lafit, Ginette, Vaessen, Thomas, de Beeck, Gommaar Op, Berghmans, Raf, Wijkhuijs, Annemarie, Müller, Norbert, Arolt, Volker, Drexhage, Hemmo, Vrieze, Elske

“…Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of inflammation-related genes in monocytes of a large and…”
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Development of an Enzyme-Linked Immune Sorbent Assay to Measure Nivolumab and Pembrolizumab Serum Concentrations by Basak, Edwin A, Wijkhuijs, Annemarie J M, Mathijssen, Ron H J, Koolen, Stijn L W, Schreurs, Marco W J

“…Treatment with monoclonal antibodies (mAbs) against programmed cell death protein 1 receptor is subject to high variation in treatment outcome among cancer…”
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Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity by Berentschot, Julia C., Drexhage, Hemmo A., Aynekulu Mersha, Daniel G., Wijkhuijs, Annemarie J. M., GeurtsvanKessel, Corine H., Koopmans, Marion P. G., Voermans, Jolanda J. C., Hendriks, Rudi W., Nagtzaam, Nicole M. A., de Bie, Maaike, Heijenbrok-Kal, Majanka H., Bek, L. Martine, Ribbers, Gerard M., van den Berg-Emons, Rita J. G., Aerts, Joachim G. J. V., Dik, Willem A., Hellemons, Merel E.

“…BackgroundMany patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling symptoms. We performed clinical and immune…”
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Fatigue in Sjögren's Syndrome: A Search for Biomarkers and Treatment Targets by Bodewes, Iris L A, van der Spek, Peter J, Leon, Leticia G, Wijkhuijs, Annemarie J M, van Helden-Meeuwsen, Cornelia G, Tas, Liselotte, Schreurs, Marco W J, van Daele, Paul L A, Katsikis, Peter D, Versnel, Marjan A

“…Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, where patients often suffer from fatigue. Biological pathways underlying fatigue are…”
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Prospective real-world study on the pharmacokinetics of pembrolizumab in patients with solid tumors by Hurkmans, Daan P., Sassen, Sebastiaan D.T., de Joode, Karlijn, Putter, Lisanne, Basak, Edwin A., Wijkhuijs, Annemarie J.M., Joerger, Markus, Debets, Reno, Koch, Birgit C.P., Van der Leest, Cor H., Schreurs, Marco W.J., van der Veldt, Astrid A.M., Aerts, Joachim G.J.V., Mathijssen, Ron H.J., Koolen, Stijn L.W.

“…BackgroundDosing schemes of pembrolizumab (anti-programmed cell death protein 1 monoclonal antibody) are solely based on pharmacokinetic (PK) modelling derived…”
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Premature T cell aging in major depression: A double hit by the state of disease and cytomegalovirus infection by Simon, Maria S., Ioannou, Magdalini, Arteaga-Henríquez, Gara, Wijkhuijs, Annemarie, Berghmans, Raf, Musil, Richard, Müller, Norbert, Drexhage, Hemmo A.

“…Previous research indicates that premature T cell senescence is a characteristic of major depressive disorder (MDD). However, known senescence inducing factors…”
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Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality? by Ioannou, Magdalini, Simon, Maria S., Borkent, Jenny, Wijkhuijs, Annemarie, Berghmans, Raf, Haarman, Bartholomeus C.M., Drexhage, Hemmo A.

“…The aim of this study was to elucidate the nature of T cell abnormalities in bipolar disorder (BD). With the use of multicolor flow cytometry, we first…”
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Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells by Schiweck, Carmen, Valles-Colomer, Mireia, Arolt, Volker, Müller, Norbert, Raes, Jeroen, Wijkhuijs, Annemarie, Claes, Stephan, Drexhage, Hemmo, Vrieze, Elske

“…•Elevated memory T helper cells in depression point to premature immune system aging.•The memory T helper cell elevation is already present in young adults…”
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Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression by Simon, Maria S., Schiweck, Carmen, Arteaga-Henríquez, Gara, Poletti, Sara, Haarman, Bartholomeus C.M., Dik, Wim A., Schwarz, Markus, Vrieze, Elske, Mikova, Olya, Joergens, Silke, Musil, Richard, Claes, Stephan, Baune, Bernhard T., Leboyer, Marion, Benedetti, Francesco, Furlan, Roberto, Berghmans, Raf, de Wit, Harm, Wijkhuijs, Annemarie, Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.

“…The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD). MDD patients (N = 140) and healthy…”
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