Search Results - "Wijeyesakere, Sanjeeva J"

Calreticulin in the immune system: ins and outs by Raghavan, Malini, Wijeyesakere, Sanjeeva J, Peters, Larry Robert, Del Cid, Natasha

“…Calreticulin is a calcium-binding chaperone that has several functions in the immune response. In the endoplasmic reticulum (ER), calreticulin facilitates the…”
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Crystal structure of patatin-17 in complex with aged and non-aged organophosphorus compounds by Wijeyesakere, Sanjeeva J, Richardson, Rudy J, Stuckey, Jeanne A

“…Patatin is a non-specific plant lipase and the eponymous member of a broad class of serine hydrolases termed the patatin-like phospholipase domain containing…”
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Profiling mechanisms that drive acute oral toxicity in mammals and its prediction via machine learning by Wijeyesakere, Sanjeeva J, Auernhammer, Tyler, Parks, Amanda, Wilson, Dan

“…Abstract We present a mechanistic machine-learning quantitative structure-activity relationship (QSAR) model to predict mammalian acute oral toxicity. We…”
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Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme by Firman, James W., Boobis, Alan, Hollnagel, Heli M., Kaiser, Stefan, Lovell, David P., Moretto, Angelo, Mueller, Severin, Rider, Cynthia V., Schmidt, Florian, Stice, Szabina, Wijeyesakere, Sanjeeva J., Borja, Geraldine, Patlewicz, Grace

“…The Cramer classification scheme has emerged as one of the most extensively-adopted predictive toxicology tools, owing in part to its employment for chemical…”
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Glycan-dependent and -independent Interactions Contribute to Cellular Substrate Recruitment by Calreticulin by Wijeyesakere, Sanjeeva J., Rizvi, Syed M., Raghavan, Malini

“…Calreticulin is an endoplasmic reticulum chaperone with specificity for monoglucosylated glycoproteins. Calreticulin also inhibits precipitation of…”
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Calreticulin Is a Thermostable Protein with Distinct Structural Responses to Different Divalent Cation Environments by Wijeyesakere, Sanjeeva J., Gafni, Ari A., Raghavan, Malini

“…Calreticulin is a soluble calcium-binding chaperone of the endoplasmic reticulum (ER) that is also detected on the cell surface and in the cytosol…”
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Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality by Sullivan, Kristie, Allen, David G, Clippinger, Amy J, Wilson, Daniel M, Edwards, Stephen W, Glover, Kyle, Mansouri, Kamel, Settivari, Raja, Wijeyesakere, Sanjeeva J, Casey, Warren

“…Efforts are underway to develop and implement nonanimal approaches which can characterize acute systemic lethality. A workshop was held in October 2019 to…”
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Neuropathy target esterase (NTE): overview and future by Richardson, Rudy J., Hein, Nichole D., Wijeyesakere, Sanjeeva J., Fink, John K., Makhaeva, Galina F.

“…[Display omitted] ► A brief overview of neuropathy target esterase (NTE) is presented. ► Toxicological data support NTE aging as the trigger for OP neuropathy…”
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Mixed Inhibition of Adenosine Deaminase Activity by 1,3-Dinitrobenzene: A Model for Understanding Cell-Selective Neurotoxicity in Chemically-Induced Energy Deprivation Syndromes in Brain by Wang, Yipei, Liu, Xin, Schneider, Brandon, Zverina, Elaina A., Russ, Kristen, Wijeyesakere, Sanjeeva J., Fierke, Carol A., Richardson, Rudy J., Philbert, Martin A.

“…Astrocytes are acutely sensitive to 1,3-dinitrobenzene (1,3-DNB) while adjacent neurons are relatively unaffected, consistent with other chemically-induced…”
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Modeling the tertiary structure of the patatin domain of neuropathy target esterase by Wijeyesakere, Sanjeeva J, Richardson, Rudy J, Stuckey, Jeanne A

“…Neuropathy target esterase (NTE) is a transmembrane protein of unknown function whose specific chemical modification by certain organophosphorus (OP) compounds…”
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The incidence of tinnitus in people with disorders of the temporomandibular joint by Upton, L George, Wijeyesakere, Sanjeeva J

“…This study was conducted to compare the prevalence of tinnitus in the general population with its incidence in people with dysfunction of the temporomandibular…”
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Diethyl [2,2,2-trifluoro-1-phenylsulfonylamino-1-(trifluoromethyl)ethyl]phosphonate by Wijeyesakere, Sanjeeva J., Nasser, Faik A., Kampf, Jeff W., Aksinenko, Alexey Y., Sokolov, Vladimir B., Malygin, Vladimir V., Makhaeva, Galina F., Richardson, Rudy J.

“…The title compound, C13H16F6NO5PS, is of interest with respect to inhibition of serine hydrolases. Its structure contains a 1.8797 (13) Å P-C bond and two…”
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CATMoS: Collaborative Acute Toxicity Modeling Suite by Mansouri, Kamel, Karmaus, Agnes L, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy E H, Allen, Dave, Alves, Vinicius M, Andrade, Carolina H, Auernhammer, Tyler R, Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V, Boyd, Stephen, Brown, J B, Capuzzi, Stephen J, Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M, Consonni, Viviana, Daga, Pankaj R, Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M, Goh, Garett, Goodman, Jonathan M, Grisoni, Francesca, Grulke, Christopher M, Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J, Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F, Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N, Myatt, Glenn J, Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K, Peryea, Tyler, Polash, Ahsan H, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel P, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C, Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V, Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M, Wedlake, Andrew J, Wijeyesakere, Sanjeeva J, Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V, Zhang, Fagen F, Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M

“…Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as…”
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Prediction of cholinergic compounds by machine-learning by Wijeyesakere, Sanjeeva J., Wilson, Daniel M., Sue Marty, Mary

“…The cholinergic nervous system plays a central role in biology and medicine and is comprised of the nicotinic (nAChR) and muscarinic receptors (mAChR) and…”
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Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite by Mansouri, Kamel, Karmaus, Agnes L, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy E H, Allen, Dave, Alves, Vinicius M, Andrade, Carolina H, Auernhammer, Tyler R, Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V, Boyd, Stephen, Brown, J B, Capuzzi, Stephen J, Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M, Consonni, Viviana, Daga, Pankaj R, Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M, Goh, Garett, Goodman, Jonathan M, Grisoni, Francesca, Grulke, Christopher M, Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J, Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F, Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N, Myatt, Glenn J, Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K, Peryea, Tyler, Polash, Ahsan H, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel P, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C, Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V, Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M, Wedlake, Andrew J, Wijeyesakere, Sanjeeva J, Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V, Zhang, Fagen F, Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M

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Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite by Mansouri, Kamel, Karmaus, Agnes, Fitzpatrick, Jeremy, Patlewicz, Grace, Pradeep, Prachi, Alberga, Domenico, Alepee, Nathalie, Allen, Timothy E.H., Allen, Dave, Alves, Vinicius M., Andrade, Carolina H., Auernhammer, Tyler R., Ballabio, Davide, Bell, Shannon, Benfenati, Emilio, Bhattacharya, Sudin, Bastos, Joyce V., Boyd, Stephen, Brown, J.B., Capuzzi, Stephen J., Chushak, Yaroslav, Ciallella, Heather, Clark, Alex M., Consonni, Viviana, Daga, Pankaj R., Ekins, Sean, Farag, Sherif, Fedorov, Maxim, Fourches, Denis, Gadaleta, Domenico, Gao, Feng, Gearhart, Jeffery M., Goh, Garett, Goodman, Jonathan M., Grisoni, Francesca, Grulke, Christopher M., Hartung, Thomas, Hirn, Matthew, Karpov, Pavel, Korotcov, Alexandru, Lavado, Giovanna J., Lawless, Michael, Li, Xinhao, Luechtefeld, Thomas, Lunghini, Filippo, Mangiatordi, Giuseppe F., Marcou, Gilles, Marsh, Dan, Martin, Todd, Mauri, Andrea, Muratov, Eugene N., Myatt, Glenn J., Nguyen, Dac-Trung, Nicolotti, Orazio, Note, Reine, Pande, Paritosh, Parks, Amanda K., Peryea, Tyler, Polash, Ahsan, Rallo, Robert, Roncaglioni, Alessandra, Rowlands, Craig, Ruiz, Patricia, Russo, Daniel, Sayed, Ahmed, Sayre, Risa, Sheils, Timothy, Siegel, Charles, Silva, Arthur C., Simeonov, Anton, Sosnin, Sergey, Southall, Noel, Strickland, Judy, Tang, Yun, Teppen, Brian, Tetko, Igor V., Thomas, Dennis, Tkachenko, Valery, Todeschini, Roberto, Toma, Cosimo, Tripodi, Ignacio, Trisciuzzi, Daniela, Tropsha, Alexander, Varnek, Alexandre, Vukovic, Kristijan, Wang, Zhongyu, Wang, Liguo, Waters, Katrina M., Wedlake, Andrew J., Wijeyesakere, Sanjeeva J., Wilson, Dan, Xiao, Zijun, Yang, Hongbin, Zahoranszky-Kohalmi, Gergely, Zakharov, Alexey V., Zhang, Fagen F., Zhang, Zhen, Zhao, Tongan, Zhu, Hao, Zorn, Kimberley M.

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Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate by Wijeyesakere, Sanjeeva J, Nasser, Faik A, Kampf, Jeff W, Aksinenko, Alexey Y, Sokolov, Vladimir B, Malygin, Vladimir V, Makhaeva, Galina F, Richardson, Rudy J

“…The title compound, C(13)H(16)F(6)NO(5)PS, is of inter-est with respect to inhibition of serine hydro-lases. Its structure contains a 1.8797 (13) Å P-C bond…”
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Neuropathy Target Esterase by Richardson, Rudy, Wijeyesakere, Sanjeeva

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Chapter 67 - Neuropathy Target Esterase by Wijeyesakere, Sanjeeva J., Richardson, Rudy J.

“…This chapter deals with neuropathy target esterase (NTE). Human NTE is now known as patatin-like phospholipase domain-containing protein-6 because of the…”
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