Search Results - "Wijesinghe, Susanne N"

Cross-species transcriptomics identifies obesity associated genes between human and mouse studies by Acharjee, Animesh, Wijesinghe, Susanne N, Russ, Dominic, Gkoutos, Georgios, Jones, Simon W

“…Fundamentally defined by an imbalance in energy consumption and energy expenditure, obesity is a significant risk factor of several musculoskeletal conditions…”
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Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets by Nanus, Dominika E, Badoume, Amel, Wijesinghe, Susanne N, Halsey, Andrea M, Hurley, Patrick, Ahmed, Zubair, Botchu, Rajesh, Davis, Edward T, Lindsay, Mark A, Jones, Simon W

“…Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA,…”
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Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses by Farah, Hussein, Wijesinghe, Susanne N, Nicholson, Thomas, Alnajjar, Fawzeyah, Certo, Michelangelo, Alghamdi, Abdullah, Davis, Edward T, Young, Stephen P, Mauro, Claudio, Jones, Simon W

“…Changes in cellular metabolism have been implicated in mediating the activated fibroblast phenotype in a number of chronic inflammatory disorders, including…”
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Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets by Wijesinghe, Susanne N., Badoume, Amel, Nanus, Dominika E., Sharma‐Oates, Archana, Farah, Hussein, Certo, Michelangelo, Alnajjar, Fawzeyah, Davis, Edward T., Mauro, Claudio, Lindsay, Mark A., Jones, Simon W.

“…Background Osteoarthritis (OA), a multifaceted condition, poses a significant challenge for the successful clinical development of therapeutics due to…”
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Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review by Wijesinghe, Susanne N, Lindsay, Mark A, Jones, Simon W

“…Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need…”
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Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges by Nicholson, Thomas A, Sagmeister, Michael, Wijesinghe, Susanne N, Farah, Hussein, Hardy, Rowan S, Jones, Simon W

“…Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions…”
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The Expression and Function of Metastases Associated Lung Adenocarcinoma Transcript-1 Long Non-Coding RNA in Subchondral Bone and Osteoblasts from Patients with Osteoarthritis by Alnajjar, Fawzeyah A, Sharma-Oates, Archana, Wijesinghe, Susanne N, Farah, Hussein, Nanus, Dominika E, Nicholson, Tom, Davis, Edward T, Jones, Simon W

“…Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic…”
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The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence by Wijesinghe, Susanne N, Anderson, James, Brown, Thomas J, Nanus, Dominika E, Housmans, Bas, Green, Jonathan A, Hackl, Matthias, Choi, Katie K, Arkill, Kenton P, Welting, Tim, James, Victoria, Jones, Simon W, Peffers, Mandy J

“…Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked…”
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Involvements of long noncoding RNAs in obesity‐associated inflammatory diseases by Wijesinghe, Susanne N., Nicholson, Thomas, Tsintzas, Kostas, Jones, Simon W.

“…Summary Obesity is associated with chronic low‐grade inflammation that affects the phenotype of multiple tissues and therefore is implicated in the development…”
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Regulation of the Inflammatory Synovial Fibroblast Phenotype by Metastasis‐Associated Lung Adenocarcinoma Transcript 1 Long Noncoding RNA in Obese Patients With Osteoarthritis by Nanus, Dominika E., Wijesinghe, Susanne N., Pearson, Mark J., Hadjicharalambous, Marina R., Rosser, Alex, Davis, Edward T., Lindsay, Mark A., Jones, Simon W.

“…Objective To identify long noncoding RNAs (lncRNAs) associated with the inflammatory phenotype of synovial fibroblasts from obese patients with osteoarthritis…”
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Immunomodulation and fibroblast dynamics driving nociceptive joint pain within inflammatory synovium: Unravelling mechanisms for therapeutic advancements in osteoarthritis by Wijesinghe, Susanne N., Ditchfield, Caitlin, Flynn, Sariah, Agrawal, Jyoti, Davis, Edward T., Dajas-Bailador, Federico, Chapman, Victoria, Jones, Simon W.

“…Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue hyperplasia, where increased infiltration of immune cells and proliferation…”
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Long Non-coding RNAs in Rheumatology by Wijesinghe, Susanne N, Lindsay, Mark A, Jones, Simon W

“…The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein…”
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Novel gene variants in patients with platelet‐based bleeding using combined exome sequencing and RNAseq murine expression data by Khan, Abdullah O., Stapley, Rachel J., Pike, Jeremy A., Wijesinghe, Susanne.N., Reyat, Jasmeet S., Almazni, Ibrahim, Machlus, Kellie R., Morgan, Neil V.

“…Essentials Identifying genetic variants in platelet disorders is challenging due to its heterogenous nature. We combine WES, RNAseq, and python‐based…”
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Cross-species transcriptomics and machine learning identifies conserved obesity associated genes in osteoarthritic joint tissues by Wijesinghe, Susanne N., Acharjee, Animesh, Russ, Dominic, Gkoutos, Georgios, Jones, Simon W.

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677 - Cross-species transcriptomics and machine learning identifies conserved obesity associated genes in osteoarthritic joint tissues by Wijesinghe, Susanne N., Acharjee, Animesh, Russ, Dominic, Gkoutos, Georgios, Jones, Simon W.

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743 - Specific sites of patient-reported joint pain coincide with presence of bone marrow lesions in knee osteoarthritis patients by Wijesinghe, Susanne N., Botchu, Rajesh, Sardeli, Amanda V., Ditchfield, Caitlin N., Davies, Edward T., Jones, Simon W.

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Specific sites of patient-reported joint pain coincide with presence of bone marrow lesions in knee osteoarthritis patients by Wijesinghe, Susanne N., Botchu, Rajesh, Sardeli, Amanda V., Ditchfield, Caitlin N., Davies, Edward T., Jones, Simon W.

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