Search Results - "Wijesekara, Anuradha V"
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Anionic phospholipids control mechanisms of GPCR-G protein recognition
Published in Nature communications (13-02-2023)“…G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly influence drug-stimulated signaling. Anionic lipids are particularly important…”
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Fast Acquisition of Proton‐Detected HETCOR Solid‐State NMR Spectra of Quadrupolar Nuclei and Rapid Measurement of NH Bond Lengths by Frequency Selective HMQC and RESPDOR Pulse Sequences
Published in Chemistry : a European journal (23-06-2020)“…Fast magic‐angle spinning (MAS), frequency selective (FS) heteronuclear multiple quantum coherence (HMQC) experiments which function in an analogous manner to…”
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Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1H Solid-State NMR Spectroscopy
Published in Molecular pharmaceutics (01-07-2019)“…Active pharmaceutical ingredients (APIs) can be prepared in many different solid forms and phases that affect their physicochemical properties and suitability…”
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4
NMR spectroscopy reveals insights into mechanisms of GPCR signaling
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (09-11-2024)Get full text
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Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors
Published in Current opinion in pharmacology (01-10-2023)“…G protein-coupled receptors (GPCRs) exhibit remarkable structural plasticity, which underlies their capacity to recognize a wide range of extracellular…”
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Comment on “Chirality-Induced Electron Spin Polarization and Enantiospecific Response in Solid-State Cross-Polarization Nuclear Magnetic Resonance”
Published in ACS nano (25-06-2019)Get full text
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7
Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1 H Solid-State NMR Spectroscopy
Published in Molecular pharmaceutics (01-07-2019)“…Active pharmaceutical ingredients (APIs) can be prepared in many different solid forms and phases that affect their physicochemical properties and suitability…”
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Structural basis for regulation of a human GPCR by membrane lipids investigated by NMR spectroscopy
Published in Biophysical journal (11-02-2022)Get full text
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9
Regulation of human A2A adenosine receptor conformational dynamics by endogenous phospholipids
Published in Biophysical journal (11-02-2022)Get full text
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10
Locating hydrogen atoms with sensitivity-enhanced NMR spectroscopy
Published in Acta crystallographica. Section A, Foundations and advances (20-07-2019)“…Abstract only…”
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Sensitizing solid-state NMR spectroscopy for the characterization of pure and formulated pharmaceuticals
Published in Acta crystallographica. Section A, Foundations and advances (20-07-2019)“…Abstract only…”
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Improved Characterization of Pure and Formulated Active Pharmaceutical Ingredients by Fast Magic Angle Spinning Solid-State NMR Spectroscopy
Published 01-01-2020“…This thesis describes improved methods for the characterization of pure and formulated solid active pharmaceutical ingredients (APIs) by solid-state nuclear…”
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Dissertation