Synthesis, Characterization and Antimicrobial Activity of Garcinol Capped Silver Nanoparticles

Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs). The formation and th...

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Bibliographic Details
Published in:	Journal of microbiology and biotechnology Vol. 29; no. 11; pp. 1841 - 1851
Main Authors:	Fernando, H.N, Kumarasinghe, K.G.U.R, Gunasekara, T.D.C.P, Wijekoon, H.P.S.K, Ekanayaka, E.M.A.K, Rajapaksha, S.P, Fernando, S.S.N, Jayaweera, P.M
Format:	Journal Article
Language:	Korean
Published:	한국미생물생명공학회 30-11-2019
Subjects:	antimicrobial activity Garcinol garcinol-capped silver nanoparticles silver nanoparticles time-kill kinetics studies Garcinol antimicrobial activity silver nanoparticles time-kill kinetics studies garcinol-capped silver nanoparticles
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Summary:	Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs). The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. The antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion assays, broth micro-dilution assays and time-kill kinetics studies against five microbial species, including Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and clinically isolated methicillin-resistant Staphylococcus aureus (MRSA). The formation of G-AgNPs is a promising novel approach to enhancing the biological activeness of silver nanoparticles, and to increase the water solubility of garcinol which creates a broad range of therapeutic applications.
Bibliography:	The Korean Society for Applied Microbiology KISTI1.1003/JNL.JAKO201907750244372
ISSN:	1017-7825 1738-8872