Search Results - "Wightman, R M"

Voltammetric Detection of 5-Hydroxytryptamine Release in the Rat Brain by Hashemi, Parastoo, Dankoski, Elyse C, Petrovic, Jelena, Keithley, Richard B, Wightman, R. M

“…5-Hydroxytryptamine (5-HT) is an important molecule in the brain that is implicated in mood and emotional processes. In vivo, its dynamic release and uptake…”
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Quantitative analysis of iontophoretic drug delivery from micropipettes by Kirkpatrick, D C, Walton, L R, Edwards, M A, Wightman, R M

“…Microiontophoresis is a drug delivery method in which an electric current is used to eject molecular species from a micropipette. It has been primarily…”
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In vivo voltammetric monitoring of catecholamine release in subterritories of the nucleus accumbens shell by Park, J, Aragona, B.J, Kile, B.M, Carelli, R.M, Wightman, R.M

“…Abstract Fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes has been used to demonstrate that sub-second changes in catecholamine…”
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Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation by Beyene, M, Carelli, R.M, Wightman, R.M

“…Abstract The mesolimbic dopamine system is critically involved in modulating reward-seeking behavior and is transiently activated upon presentation of…”
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Aversive stimulus differentially triggers subsecond dopamine release in reward regions by Budygin, E.A, Park, J, Bass, C.E, Grinevich, V.P, Bonin, K.D, Wightman, R.M

“…Abstract Aversive stimuli have a powerful impact on behavior and are considered to be the opposite valence of pleasure. Recent studies have determined some…”
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Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study by Garris, PA, Wightman, RM

“…The regulation of extracellular dopamine (DA) concentrations was examined and compared in vivo in four projection fields of mesotelencephalic dopaminergic…”
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Subsecond Adsorption and Desorption of Dopamine at Carbon-Fiber Microelectrodes by Bath, Bradley D, Michael, Darren J, Trafton, B. Jill, Joseph, Joshua D, Runnels, Petrise L, Wightman, R. Mark

“…High-repetition fast-scan cyclic voltammetry and chronoamperometry were used to quantify and characterize the kinetics of dopamine and dopamine-o-quinone…”
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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter by Giros, Bruno, Jaber, Mohamed, Jones, Sara R, Wightman, R. Mark, Caron, Marc G

“…Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter…”
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A role for presynaptic mechanisms in the actions of nomifensine and haloperidol by GARRIS, P. A, BUDYGIN, E. A, PHILLIPS, P. E. M, VENTON, B. J, ROBINSON, D. L, BERGSTROM, B. P, REBEC, G. V, WIGHTMAN, R. M

“…Psychomotor stimulants and neuroleptics exert multiple effects on dopaminergic signaling and produce the dopamine (DA)-related behaviors of motor activation…”
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Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry by WALKER, Q. D, ROONEY, M. B, WIGHTMAN, R. M, KUHN, C. M

“…The present studies investigated sexual dimorphisms in dopamine release and uptake using fast-scan cyclic voltammetry in anesthetized rats and in brain slices…”
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Extinction of Cocaine Self-Administration Reveals Functionally and Temporally Distinct Dopaminergic Signals in the Nucleus Accumbens by Stuber, Garret D., Wightman, R. Mark, Carelli, Regina M.

“…While Pavlovian and operant conditioning influence drug-seeking behavior, the role of rapid dopamine signaling in modulating these processes is unknown. During…”
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Temporally Resolved Catecholamine Spikes Correspond to Single Vesicle Release from Individual Chromaffin Cells by Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., Viveros, O. H.

“…Secretion of catecholamines from single bovine chromaffin cells in culture was elicited by brief pressure ejections from a micropipette containing nicotine,…”
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Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation by Wightman, R. Mark, Garris, Paul A, Kilpatrick, Michaux, Bunin, Melissa A, Michael, Darren, Walker, Q. David

“…Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system,. One behavioural paradigm that supports this hypothesis is…”
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Paracrine neurotransmission in the CNS: involvement of 5-HT by Bunin, Melissa A, Wightman, R.Mark

“…While GABA and glutamate have an established synaptic function in the CNS, recent evidence suggests 5-HT neurotransmission is predominantly paracrine. As the…”
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Different effects of cocaine and nomifensine on dopamine uptake in the caudate-putamen and nucleus accumbens by Jones, S R, Garris, P A, Wightman, R M

“…The effects of cocaine and nomifensine on the uptake of dopamine have been compared in the caudate-putamen and nucleus accumbens of rat brain slices…”
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Functional microcircuitry in the accumbens underlying drug addiction: insights from real-time signaling during behavior by Carelli, Regina M, Wightman, R Mark

“…An understanding of the neurobiological basis of drug addiction requires examination of real-time (subsecond) cellular and chemical responses in the brain…”
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Overoxidized Polypyrrole-Coated Carbon Fiber Microelectrodes for Dopamine Measurements with Fast-Scan Cyclic Voltammetry by Pihel, Karin, Walker, Q. David, Wightman, R. Mark

“…Thin films of overoxidized polypyrrole have been electrochemically coated onto carbon fiber microelectrodes and used for dopamine measurements with…”
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Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain by Garris, PA, Ciolkowski, EL, Pastore, P, Wightman, RM

“…Synaptic release of dopamine in the nucleus accumbens of the intact rat brain elicited by a single electrical impulse applied to ascending dopaminergic fibers…”
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Extracellular dopamine dynamics in rat caudate–putamen during experimenter-delivered and intracranial self-stimulation by Kilpatrick, M.R, Rooney, M.B, Michael, D.J, Wightman, R.M

“…Intracranial self-stimulation is an operant behavior whereby animals are conditioned to press a lever in order to receive an electrical stimulation of their…”
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Electrochemistry and Electrogenerated Chemiluminescence Processes of the Components of Aluminum Quinolate/Triarylamine, and Related Organic Light-Emitting Diodes by Anderson, J. D, McDonald, E. M, Lee, P. A, Anderson, M. L, Ritchie, E. L, Hall, H. K, Hopkins, T, Mash, E. A, Wang, J, Padias, A, Thayumanavan, S, Barlow, S, Marder, S. R, Jabbour, G. E, Shaheen, S, Kippelen, B, Peyghambarian, N, Wightman, R. M, Armstrong, N. R

“…Solution electrochemical studies have been conducted of the principle lumophores, dopants, and hole-transport agents of aluminum-quinolate(Alq3)-based organic…”
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