Search Results - "Wight, Thomas N"

Provisional matrix: A role for versican and hyaluronan by Wight, Thomas N.

“…Hyaluronan and versican are extracellular matrix (ECM) components that are enriched in the provisional matrices that form during the early stages of…”
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The extracellular matrix: an active or passive player in fibrosis? by Wight, Thomas N, Potter-Perigo, Susan

“…Fibrosis is characterized by excessive accumulation of collagen and other extracellular matrix (ECM) components, and this process has been likened to aberrant…”
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Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation by Wight, Thomas N, Kang, Inkyung, Evanko, Stephen P, Harten, Ingrid A, Chang, Mary Y, Pearce, Oliver M T, Allen, Carys E, Frevert, Charles W

“…The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor…”
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Exuberant fibroblast activity compromises lung function via ADAMTS4 by Boyd, David F., Allen, E. Kaitlynn, Randolph, Adrienne G., Guo, Xi-zhi J., Weng, Yunceng, Sanders, Catherine J., Bajracharya, Resha, Lee, Natalie K., Guy, Clifford S., Vogel, Peter, Guan, Wenda, Li, Yimin, Liu, Xiaoqing, Novak, Tanya, Newhams, Margaret M., Fabrizio, Thomas P., Wohlgemuth, Nicholas, Mourani, Peter M., Wight, Thomas N., Schultz-Cherry, Stacey, Cormier, Stephania A., Shaw-Saliba, Kathryn, Pekosz, Andrew, Rothman, Richard E., Chen, Kuan-Fu, Yang, Zifeng, Webby, Richard J., Zhong, Nanshan, Crawford, Jeremy Chase, Thomas, Paul G.

“…Severe respiratory infections can result in acute respiratory distress syndrome (ARDS) 1 . There are no effective pharmacological therapies that have been…”
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Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy by Järveläinen, Hannu, Sainio, Annele, Koulu, Markku, Wight, Thomas N, Penttinen, Risto

“…The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans…”
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4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer by Nagy, Nadine, Kuipers, Hedwich F, Frymoyer, Adam R, Ishak, Heather D, Bollyky, Jennifer B, Wight, Thomas N, Bollyky, Paul L

“…Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple…”
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Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection by Kang, Inkyung, Chang, Mary Y., Wight, Thomas N., Frevert, Charles W.

“…Proteoglycans (PGs) are complex, multifaceted molecules that participate in diverse interactions vital for physiological and pathological processes. As…”
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Versican and the regulation of cell phenotype in disease by Wight, Thomas N., Kinsella, Michael G., Evanko, Stephen P., Potter-Perigo, Susan, Merrilees, Mervyn J.

“…Versican is an extracellular matrix (ECM) proteoglycan that is present in the pericellular environment of most tissues and increases in many different…”
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Interplay of extracellular matrix and leukocytes in lung inflammation by Wight, Thomas N., Frevert, Charles W., Debley, Jason S., Reeves, Stephen R., Parks, William C., Ziegler, Steven F.

“…•Leukocytes interact with lung extracellular matrix (ECM) during inflammation.•This interaction affects how leukocytes accumulate, migrate, and…”
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Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury by Petz, Anne, Grandoch, Maria, Gorski, Daniel J, Abrams, Marcel, Piroth, Marco, Schneckmann, Rebekka, Homann, Susanne, Müller, Julia, Hartwig, Sonja, Lehr, Stefan, Yamaguchi, Yu, Wight, Thomas N, Gorressen, Simone, Ding, Zhaoping, Kötter, Sebastian, Krüger, Martina, Heinen, Andre, Kelm, Malte, Gödecke, Axel, Flögel, Ulrich, Fischer, Jens W

“…RATIONALE:Immediate changes in the ECM (extracellular matrix) microenvironment occur after myocardial ischemia and reperfusion (I/R) injury. OBJECTIVE:Aim of…”
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Versican: a versatile extracellular matrix proteoglycan in cell biology by Wight, Thomas N

“…Versican is a large extracellular matrix proteoglycan that is present in a variety of tissues. Successful cloning of the gene in man, mouse, cow and chicken…”
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Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1 by Kanter, Jenny E, Kramer, Farah, Barnhart, Shelley, Averill, Michelle M, Vivekanandan-Giri, Anuradha, Vickery, Thad, Li, Lei O, Becker, Lev, Yuan, Wei, Chait, Alan, Braun, Kathleen R, Potter-Perigo, Susan, Sanda, Srinath, Wight, Thomas N, Pennathur, Subramaniam, Serhan, Charles N, Heinecke, Jay W, Coleman, Rosalind A, Bornfeldt, Karin E

“…The mechanisms that promote an inflammatory environment and accelerated atherosclerosis in diabetes are poorly understood. We show that macrophages isolated…”
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Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization by Kuipers, Hedwich F., Rieck, Mary, Gurevich, Irina, Nagy, Nadine, Butte, Manish J., Negrin, Robert S., Wight, Thomas N., Steinman, Lawrence, Bollyky, Paul L.

“…The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune inflammation, including white matter lesions in multiple sclerosis…”
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A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro by Evanko, Stephen P., Gooden, Michel D., Kang, Inkyung, Chan, Christina K., Vernon, Robert B., Wight, Thomas N.

“…Hyaluronan and proteoglycan link protein 1 (HAPLN1) stabilizes interactions between two important extracellular matrix (ECM) macromolecules, versican and…”
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Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer by Hirani, Priyanka, Gauthier, Valentine, Allen, Carys E., Wight, Thomas N., Pearce, Oliver M. T.

“…A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue…”
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Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components by Reeves, Stephen R., MD, PhD, Kolstad, Tessa, BS, Lien, Tin-Yu, BS, Elliott, Molly, BS, Ziegler, Steven F., PhD, Wight, Thomas N., PhD, Debley, Jason S., MD, MPH

“…Background Airway remodeling might explain lung function decline among asthmatic children. Extracellular matrix (ECM) deposition by human lung fibroblasts…”
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Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity by Han, Chang Yeop, Kang, Inkyung, Harten, Ingrid A., Gebe, John A., Chan, Christina K., Omer, Mohamed, Alonge, Kimberly M., den Hartigh, Laura J., Gomes Kjerulf, Diego, Goodspeed, Leela, Subramanian, Savitha, Wang, Shari, Kim, Francis, Birk, David E., Wight, Thomas N., Chait, Alan

“…Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue…”
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Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts by Evanko, Stephen P., Potter-Perigo, Susan, Petty, Loreen J., Workman, Gail A., Wight, Thomas N.

“…The contribution of hyaluronan-dependent pericellular matrix to TGF-β1-driven induction and maintenance of myofibroblasts is not understood. Hyaluronan is an…”
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A role for proteoglycans in vascular disease by Wight, Thomas N.

“…The content of proteoglycans (PGs) is low in the extracellular matrix (ECM) of vascular tissue, but increases dramatically in all phases of vascular disease…”
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Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs by Chang, Mary Y, Kang, Inkyung, Gale, Jr, Michael, Manicone, Anne M, Kinsella, Michael G, Braun, Kathleen R, Wigmosta, Tara, Parks, William C, Altemeier, William A, Wight, Thomas N, Frevert, Charles W

“…Growing evidence suggests that versican is important in the innate immune response to lung infection. Our goal was to understand the regulation of…”
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