Search Results - "Wight, T N"

Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation by Ruppert, S. M., Hawn, T. R., Arrigoni, A., Wight, T. N., Bollyky, P. L.

“…The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of…”
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Heparan Sulfate in Perlecan Promotes Mouse Atherosclerosis: Roles in Lipid Permeability, Lipid Retention, and Smooth Muscle Cell Proliferation by Tran-Lundmark, Karin, Tran, Phan-Kiet, Paulsson-Berne, Gabrielle, Fridén, Vincent, Soininen, Raija, Tryggvason, Karl, Wight, Thomas N, Kinsella, Michael G, Borén, Jan, Hedin, Ulf

“…Heparan sulfate (HS) has been proposed to be antiatherogenic through inhibition of lipoprotein retention, inflammation, and smooth muscle cell proliferation…”
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Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells by Evanko, Stephen P, Angello, John C, Wight, Thomas N

“…The accumulation of hyaluronan (HA) and the HA-binding proteoglycan versican around smooth muscle cells in lesions of atherosclerosis suggests that together…”
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Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta by Evanko, SP, Raines, EW, Ross, R, Gold, LI, Wight, TN

“…The accumulation of proteoglycans (PGs) in atherosclerosis contributes to disease progression and stenosis and may partly depend on local regulation by growth…”
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Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans by Nakashima, Yutaka, Wight, Thomas N., Sueishi, Katsuo

“…This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy…”
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Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding by Borén, J, Olin, K, Lee, I, Chait, A, Wight, T N, Innerarity, T L

“…The subendothelial retention of LDLs through their interaction with proteoglycans has been proposed to be a key process in the pathogenesis of atherosclerosis…”
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Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques : Colocalization of biglycan with apolipoproteins by O'BRIEN, K. D, OLIN, K. L, ALPERS, C. E, CHIU, W, FERGUSON, M, HUDKINS, K, WIGHT, T. N, CHAIT, A

“…Because the content of specific proteoglycans and apolipoproteins is increased in atherosclerotic plaques and in vitro studies have suggested a role for…”
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The Sulfate Moieties of Glycosaminoglycans Are Critical for the Enhancement of β‐Amyloid Protein Fibril Formation by Castillo, Gerardo M., Lukito, Widia, Wight, Thomas N., Snow, Alan D.

“…: Our previous studies have demonstrated that perlecan and perlecan‐derived glycosaminoglycans (GAGs) not only bind β‐amyloid protein (Aβ) 1‐40 and 1‐42, but…”
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Perlecan Binds to the β‐Amyloid Proteins (Aβ) of Alzheimer's Disease, Accelerates Aβ Fibril Formation, and Maintains Aβ Fibril Stability by Castillo, Gerardo M., Ngo, Catherine, Cummings, Joel, Wight, Thomas N., Snow, Alan D.

“…: Perlecan is a specific heparan sulfate proteoglycan that accumulates in the fibrillar β‐amyloid (Aβ) deposits of Alzheimer's disease. Perlecan purified from…”
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Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries by Riessen, R, Isner, JM, Blessing, E, Loushin, C, Nikol, S, Wight, TN

“…Proteoglycans are important constituents of blood vessels and accumulate in various forms of vascular disease. Little is known concerning the proteoglycan…”
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Platelet-Derived Growth Factor Stimulates the Formation of Versican–Hyaluronan Aggregates and Pericellular Matrix Expansion in Arterial Smooth Muscle Cells by Evanko, Stephen P., Johnson, Pamela Y., Braun, Kathleen R., Underhill, Charles B., Dudhia, Jayesh, Wight, Thomas N.

“…Hyaluronan and versican-rich pericellular matrices form around arterial smooth muscle cells (ASMC) preferentially during the detachment phase of proliferation…”
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Smooth muscle cell expression of extracellular matrix genes after arterial injury by Nikkari, ST, Jarvelainen, HT, Wight, TN, Ferguson, M, Clowes, AW

“…Accumulation of extracellular matrix (ECM) after arterial injury is an important event in the development of intimal thickening and is modulated by heparin. To…”
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Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme by Halpert, I. (Barnes-Jewish Hospital, St. Louis, MO.), Sires, U.I, Roby, J.D, Potter-Perigo, S, Wight, T.N, Shapiro, S.D, Welgus, H.G, Wickline, S.A, Parks, W.C

“…Certain matrix metalloproteinases (MMP) are expressed within the fibrous areas surrounding acellular lipid cores of atherosclerotic plaques, suggesting that…”
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The pharmacokinetics and dosing of oral 4‐methylumbelliferone for inhibition of hyaluronan synthesis in mice by Kuipers, H. F., Nagy, N., Ruppert, S. M., Sunkari, V. G., Marshall, P. L., Gebe, J. A., Ishak, H. D., Keswani, S. G., Bollyky, J., Frymoyer, A. R., Wight, T. N., Steinman, L., Bollyky, P. L.

“…Summary Recently, there has been considerable interest in using 4‐methylumbelliferone (4‐MU) to inhibit hyaluronan (HA) synthesis in mouse models of cancer,…”
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Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding by NIGRO, J, BALLINGER, M. L, DILLEY, R. J, JENNINGS, G. L. R, WIGHT, T. N, LITTLE, P. J

“…Vascular disease in type 2 diabetes is associated with an up-regulation of atherogenic growth factors, which stimulate matrix synthesis including…”
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Intimal fibromuscular hyperplasia at the venous anastomosis of PTFE grafts in hemodialysis patients: clinical, immunocytochemical. light and electron microscopic assessment by SWEDBERG, S. H, BROWN, B. G, SIGLEY, R, WIGHT, T. N, GORDON, D, NICHOLLS, S. C

“…Failure of arteriovenous communications used for chronic hemodialysis was studied during sequential 5-year periods after placement of either endogenous…”
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Selective deposits of versican in the extracellular matrix of restenotic lesions from human peripheral arteries by Wight, TN, Lara, S, Riessen, R, Le Baron, R, Isner, J

“…Although a large percentage of the volume of human restenotic arterial lesions is occupied by extracellular matrix (ECM), the composition and organization of…”
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The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease by Snow, AD, Mar, H, Nochlin, D, Kimata, K, Kato, M, Suzuki, S, Hassell, J, Wight, TN

“…Two immunocytochemical probes were used to specifically identify and localize heparan sulphate proteoglycans (HSPGs) in 17 cases of Alzheimer's disease (AD). A…”
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Early accumulation of heparan sulfate in neurons and in the beta- amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome by Snow, AD, Mar, H, Nochlin, D, Sekiguchi, RT, Kimata, K, Koike, Y, Wight, TN

“…A monoclonal antibody (HK-249) that recognizes a glucosamine sulfate alpha 1---4 glucuronic acid-containing determinant in heparan sulfate (HS) chains of a…”
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Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells by Schönherr, E., Järveläinen, H.T., Sandell, L.J., Wight, T.N.

“…Platelet-derived growth factor (PDGF) and transforming growth factor-beta 1 (TGF-beta 1) increase [35S]sulfate incorporation into proteoglycan (PG) by monkey…”
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