Search Results - "Wigger, Leonore"

Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system by Chai, Phing Chian, Cruchet, Steeve, Wigger, Leonore, Benton, Richard

“…Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe…”
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Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans by Wigger, Leonore, Cruciani-Guglielmacci, Céline, Nicolas, Anthony, Denom, Jessica, Fernandez, Neïké, Fumeron, Frédéric, Marques-Vidal, Pedro, Ktorza, Alain, Kramer, Werner, Schulte, Anke, Le Stunff, Hervé, Liechti, Robin, Xenarios, Ioannis, Vollenweider, Peter, Waeber, Gérard, Uphues, Ingo, Roussel, Ronan, Magnan, Christophe, Ibberson, Mark, Thorens, Bernard

“…Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic…”
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Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock by Bignon, Yohan, Wigger, Leonore, Ansermet, Camille, Weger, Benjamin D, Lagarrigue, Sylviane, Centeno, Gabriel, Durussel, Fanny, Götz, Lou, Ibberson, Mark, Pradervand, Sylvain, Quadroni, Manfredo, Weger, Meltem, Amati, Francesca, Gachon, Frédéric, Firsov, Dmitri

“…Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we…”
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A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation by Ince, Yetkin Çaka, Krahmer, Johanna, Fiorucci, Anne-Sophie, Trevisan, Martine, Galvão, Vinicius Costa, Wigger, Leonore, Pradervand, Sylvain, Fouillen, Laetitia, Van Delft, Pierre, Genva, Manon, Mongrand, Sebastien, Gallart-Ayala, Hector, Ivanisevic, Julijana, Fankhauser, Christian

“…Plant growth ultimately depends on fixed carbon, thus the available light for photosynthesis. Due to canopy light absorption properties, vegetative shade…”
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System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells by Wigger, Leonore, Casals-Casas, Cristina, Baruchet, Michaël, Trang, Khanh B, Pradervand, Sylvain, Naldi, Aurélien, Desvergne, Béatrice

“…Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous…”
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Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes by Wigger, Leonore, Barovic, Marko, Brunner, Andreas-David, Marzetta, Flavia, Schöniger, Eyke, Mehl, Florence, Kipke, Nicole, Friedland, Daniela, Burdet, Frederic, Kessler, Camille, Lesche, Mathias, Thorens, Bernard, Bonifacio, Ezio, Legido-Quigley, Cristina, Barbier Saint Hilaire, Pierre, Delerive, Philippe, Dahl, Andreas, Klose, Christian, Gerl, Mathias J., Simons, Kai, Aust, Daniela, Weitz, Jürgen, Distler, Marius, Schulte, Anke M., Mann, Matthias, Ibberson, Mark, Solimena, Michele

“…Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or diseased brain-dead donors and thus cannot accurately describe…”
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Plasma triacylglycerols are biomarkers of β-cell function in mice and humans by Sánchez-Archidona, Ana Rodríguez, Cruciani-Guglielmacci, Céline, Roujeau, Clara, Wigger, Leonore, Lallement, Justine, Denom, Jessica, Barovic, Marko, Kassis, Nadim, Mehl, Florence, Weitz, Jurgen, Distler, Marius, Klose, Christian, Simons, Kai, Ibberson, Mark, Solimena, Michele, Magnan, Christophe, Thorens, Bernard

“…To find plasma biomarkers prognostic of type 2 diabetes, which could also inform on pancreatic β-cell deregulations or defects in the function of insulin…”
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Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine by Thorens, Bernard, Rodriguez, Ana, Cruciani-Guglielmacci, Céline, Wigger, Leonore, Ibberson, Mark, Magnan, Christophe

“…Progression from pre-diabetes to type 2 diabetes (T2D) and from T2D to insulin requirement proceeds at very heterogenous rates among patient populations, and…”
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A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice by Mang, Géraldine M, Pradervand, Sylvain, Du, Ngoc-Hien, Arpat, Alaaddin Bulak, Preitner, Frédéric, Wigger, Leonore, Gatfield, David, Franken, Paul

“…MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. MiRNAs are implicated in various biological…”
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Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion by Cruciani-Guglielmacci, Céline, Bellini, Lara, Denom, Jessica, Oshima, Masaya, Fernandez, Neïké, Normandie-Levi, Priscilla, Berney, Xavier P, Kassis, Nadim, Rouch, Claude, Dairou, Julien, Gorman, Tracy, Smith, David M, Marley, Anna, Liechti, Robin, Kuznetsov, Dmitry, Wigger, Leonore, Burdet, Frédéric, Lefèvre, Anne-Laure, Wehrle, Isabelle, Uphues, Ingo, Hildebrandt, Tobias, Rust, Werner, Bernard, Catherine, Ktorza, Alain, Rutter, Guy A, Scharfmann, Raphael, Xenarios, Ioannis, Le Stunff, Hervé, Thorens, Bernard, Magnan, Christophe, Ibberson, Mark

“…Abstract Objective In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In…”
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Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA by Aghagolzadeh, Parisa, Plaisance, Isabelle, Bernasconi, Riccardo, Treibel, Thomas A., Quetglas, Carlos Pulido, Wyss, Tania, Wigger, Leonore, Nemir, Mohamed, Sarre, Alexandre, Chouvardas, Panagiotis, Johnson, Rory, González, Arantxa, Pedrazzini, Thierry

“…Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to…”
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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes by Solimena, Michele, Schulte, Anke M., Marselli, Lorella, Ehehalt, Florian, Richter, Daniela, Kleeberg, Manuela, Mziaut, Hassan, Knoch, Klaus-Peter, Parnis, Julia, Bugliani, Marco, Siddiq, Afshan, Jörns, Anne, Burdet, Frédéric, Liechti, Robin, Suleiman, Mara, Margerie, Daniel, Syed, Farooq, Distler, Marius, Grützmann, Robert, Petretto, Enrico, Moreno-Moral, Aida, Wegbrod, Carolin, Sönmez, Anke, Pfriem, Katja, Friedrich, Anne, Meinel, Jörn, Wollheim, Claes B., Baretton, Gustavo B., Scharfmann, Raphael, Nogoceke, Everson, Bonifacio, Ezio, Sturm, Dorothée, Meyer-Puttlitz, Birgit, Boggi, Ugo, Saeger, Hans-Detlev, Filipponi, Franco, Lesche, Mathias, Meda, Paolo, Dahl, Andreas, Wigger, Leonore, Xenarios, Ioannis, Falchi, Mario, Thorens, Bernard, Weitz, Jürgen, Bokvist, Krister, Lenzen, Sigurd, Rutter, Guy A., Froguel, Philippe, von Bülow, Manon, Ibberson, Mark, Marchetti, Piero

“…Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the…”
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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner by Kompotis, Konstantinos, Mang, Géraldine M, Hubbard, Jeffrey, Jimenez, Sonia, Emmenegger, Yann, Polysopoulos, Christos, Hor, Charlotte N, Wigger, Leonore, Hébert, Sébastien S, Mongrain, Valérie, Franken, Paul

“…MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that have been implicated in a plethora of neuronal processes. Nevertheless,…”
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Plasma triacylglycerols are biomarkers of (3-cell function in mice and humans by Sanchez-Archidona, Ana Rodriguez, Cruciani-Guglielmacci, Celine, Roujeau, Clara, Wigger, Leonore, Lallement, Justine, Denom, Jessica, Barovic, Marko, Kassis, Nadim, Mehl, Florence, Weitz, Jurgen, Distler, Marius, Klose, Christian, Simons, Kai, Ibberson, Mark, Solimena, Michele, Magnan, Christophe, Thorens, Bernard

“…Objectives: To find plasma biomarkers prognostic of type 2 diabetes, which could also inform on pancreatic (3-cell deregulations or defects in the function of…”
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Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients by Fontana, Pierre, Ibberson, Mark, Stevenson, Brian, Wigger, Leonore, Daali, Youssef, Niknejad, Anne, Mach, François, Docquier, Mylène, Xenarios, Ioannis, Cuisset, Thomas, Alessi, Marie‐Christine, Reny, Jean‐Luc

“…Background On‐clopidogrel platelet reactivity (PR) is associated with the risk of thrombotic or bleeding event in selected populations of high‐risk patients…”
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A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice by Mehl, Florence, Sánchez-Archidona, Ana Rodríguez, Meitil, Ida, Gerl, Mathias, Cruciani-Guglielmacci, Céline, Wigger, Leonore, Le Stunff, Hervé, Meneyrol, Kelly, Lallement, Justine, Denom, Jessica, Klose, Christian, Simons, Kai, Pagni, Marco, Magnan, Christophe, Ibberson, Mark, Thorens, Bernard

“…To identify the pathways that are coordinately regulated in pancreatic β cells, muscle, liver, and fat to control fasting glycemia we fed C57Bl/6, DBA/2, and…”
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Malaria haplotype frequency estimation by Wigger, Leonore, Vogt, Julia E., Roth, Volker

“…We present a Bayesian approach for estimating the relative frequencies of multi‐single nucleotide polymorphism (SNP) haplotypes in populations of the malaria…”
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A Neuron-Specific Deletion of the MicroRNA-Processing Enzyme DICER Induces Severe but Transient Obesity in Mice: e0116760 by Mang, Geraldine M, Pradervand, Sylvain, Du, Ngoc-Hien, Arpat, Alaaddin Bulak, Preitner, Frederic, Wigger, Leonore, Gatfield, David, Franken, Paul

“…MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. MiRNAs are implicated in various biological…”
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Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. study by Fumeron, Frédéric, Nicolas, Anthony, Bastard, Jean-Philippe, Fellahi, Soraya, Wigger, Léonore, Ibberson, Mark, Cruciani-Guglielmacci, Céline, Le Stunff, Hervé, Velho, Gilberto, Magnan, Christophe, Marre, Michel M., Balkau, Beverley, Roussel, Ronan

“…AIM:In the D.E.S.I.R. cohort, higher consumption of dairy products was associated with lower incidence of hyperglycaemia, and dihydroceramide concentrations…”
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