Search Results - "Wigg, Andrew M"

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design by Greenspan, Paul D, Clark, Kirk L, Tommasi, Ruben A, Cowen, Scott D, McQuire, Leslie W, Farley, David L, van Duzer, John H, Goldberg, Ronald L, Zhou, Huanghai, Du, Zhengming, Fitt, John J, Coppa, David E, Fang, Zheng, Macchia, William, Zhu, Lijuan, Capparelli, Michael P, Goldstein, Robert, Wigg, Andrew M, Doughty, John R, Bohacek, Regine S, Knap, Ania K

“…Cathepsin B is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and…”
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N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B by Greenspan, Paul D., Clark, Kirk L., Cowen, Scott D., McQuire, Leslie W., Tommasi, Ruben A., Farley, David L., Quadros, Elizabeth, Coppa, David E., Du, Zengming, Fang, Zheng, Zhou, Huanghai, Doughty, John, Toscano, Karen T., Wigg, Andrew M., Zhou, Siyuan

“…To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P 2–P 3 amide group was replaced with an…”
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A comparison of endothelin-converting enzyme activity from primary porcine aortic endothelial cells with activities in cultured human cell lines by Knap, A K, Wigg, A M

“…We examined four commercially available human cell lines for endothelin-converting-enzyme-(ECE) like activity and compared the results with primary porcine…”
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