Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome

Heijnen et al discuss their study which aim to determine whether these subphenotypes and their prognostic and potential for predictive enrichment could be extended to other patients in the ICU, irrespective of fulfilling the definition of acute respiratory distress syndrome (ARDS). This is a seconda...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 203; no. 12; pp. 1503 - 1511
Main Authors:	Heijnen, Nanon F. L., Hagens, Laura A., Smit, Marry R., Cremer, Olaf L., Ong, David S. Y., van der Poll, Tom, van Vught, Lonneke A., Scicluna, Brendon P., Schnabel, Ronny M., van der Horst, Iwan C. C., Schultz, Marcus J., Bergmans, Dennis C. J. J., Bos, Lieuwe D. J., de Beer, Friso M., Bos, Lieuwe D., Glas, Gerie J., Horn, Janneke, Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T., Huson, Mischa A., Scicluna, Brendon, Schouten, Laura R., Straat, Marleen, Wieske, Luuk, Wievel, Maryse A., Witteveen, Esther, Bonten, Marc J., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Varkila, Meri R., Verboom, Diana M.
Format:	Journal Article
Language:	English
Published:	New York American Thoracic Society 15-06-2021
Subjects:	Critical care Genotype & phenotype Intensive care Medical prognosis Respiratory diseases Respiratory distress syndrome Ventilation
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Summary:	Heijnen et al discuss their study which aim to determine whether these subphenotypes and their prognostic and potential for predictive enrichment could be extended to other patients in the ICU, irrespective of fulfilling the definition of acute respiratory distress syndrome (ARDS). This is a secondary analysis of a prospective observational study of adult patients admitted to the ICU. We tested the prognostic enrichment of both cluster-derived and latent-class analysis (LCA)-derived biological ARDS subphenotypes by evaluating the association with clinical outcome (ICU-day, 30-day mortality, and ventilator-free days) using logistic regression and Cox regression analysis. We performed a principal component analysis to compare blood leukocyte gene expression profiles between subphenotypes and the presence of ARDS. The results revealed that the prognostic and potential for predictive enrichment of biological ARDS subphenotypes may be extended to mechanically ventilated critically ill patients without ARDS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1073-449X 1535-4970
DOI:	10.1164/rccm.202006-2522OC