Search Results - "Wiesel, Philippe"

Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial by Jones, David, Carbone, Marco, Invernizzi, Pietro, Little, Nicola, Nevens, Frederik, Swain, Mark G, Wiesel, Philippe, Levy, Cynthia

“…There is a real unmet need for primary biliary cholangitis (PBC) treatments that can improve quality of life impacting symptoms. In this post hoc analysis, we…”
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Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3 by Werner, Frank, Jain, Mukesh K., Feinberg, Mark W., Sibinga, Nicholas E.S., Pellacani, Andrea, Wiesel, Philippe, Chin, Michael T., Topper, James N., Perrella, Mark A., Lee, Mu-En

“…Activated macrophages are critical cellular participants in inflammatory disease states. Transforming growth factor (TGF)-β1 is a growth factor with…”
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Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages by Werner, Frank, Feinberg, Mark W., Jain, Mukesh K., Sibinga, Nicholas E.S., Wiesel, Philippe, Wang, Hong, Topper, James N., Perrella, Mark A., Lee, Mu-En

“…Matrix metalloproteinases (MMP) have been identified in vulnerable areas of atherosclerotic plaques and may contribute to plaque instability through…”
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Two-Kidney, One Clip and One-Kidney, One Clip Hypertension in Mice by Wiesel, Philippe, Mazzolai, Lucia, Nussberger, Jurg, Pedrazzini, Thierry

“…The mouse remains the animal of choice in transgenic experiments, creating a need for methods of evaluating the physiology of genetically modified animals. We…”
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Exacerbation of Chronic Renovascular Hypertension and Acute Renal Failure in Heme Oxygenase-1–Deficient Mice by Wiesel, Philippe, Patel, Anand P, Carvajal, Irvith M, Wang, Zhi Yuan, Pellacani, Andrea, Maemura, Koji, DiFonzo, Nicole, Rennke, Helmut G, Layne, Matthew D, Yet, Shaw-Fang, Lee, Mu-En, Perrella, Mark A

“…ABSTRACT—Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to generate carbon monoxide (a vasodilatory gas that has…”
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Thioredoxin Facilitates the Induction of Heme Oxygenase-1 in Response to Inflammatory Mediators by Wiesel, Philippe, Foster, Lauren C., Pellacani, Andrea, Layne, Matthew D., Hsieh, Chung-Ming, Huggins, Gordon S., Strauss, Phyllis, Yet, Shaw-Fang, Perrella, Mark A.

“…Heme oxygenase (HO)-1 is a stress response protein that is regulated by oxidative stress. HO-1 catalyzes the generation of biliverdin, carbon monoxide, and…”
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Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial by Invernizzi, Pietro, Carbone, Marco, Jones, David, Levy, Cynthia, Little, Nicola, Wiesel, Philippe, Nevens, Frederik

“…Background Primary biliary cholangitis (PBC) is a rare liver disease with significant unmet need for second‐line/add‐on treatments. Setanaxib, a NOX1/4…”
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NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors by Ford, Kirsty, Hanley, Christopher J, Mellone, Massimiliano, Szyndralewiez, Cedric, Heitz, Freddy, Wiesel, Philippe, Wood, Oliver, Machado, Maria, Lopez, Maria-Antoinette, Ganesan, Anusha-Preethi, Wang, Chuan, Chakravarthy, Ankur, Fenton, Tim R, King, Emma V, Vijayanand, Pandurangan, Ottensmeier, Christian H, Al-Shamkhani, Aymen, Savelyeva, Natalia, Thomas, Gareth J

“…Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated…”
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Quality of life outcomes in patients with primary biliary cholangitis treated with setanaxib: post-hoc results from a phase 2 randomised, placebo-controlled trial by Jones, David, Carbone, Marco, Invernizzi, Pietro, Nevens, Frederik, Swain, Mark G., Wiesel, Philippe, Levy, Cynthia

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Aortic Connexin43 Is Decreased During Hypertension Induced by Inhibition of Nitric Oxide Synthase by Haefliger, Jacques-Antoine, Meda, Paolo, Formenton, Andrea, Wiesel, Philippe, Zanchi, Anne, Brunner, Hans R, Nicod, Pascal, Hayoz, Daniel

“…Connexin43 (Cx43), the predominant gap junction protein in vessels and heart, is involved in the control of cell-to-cell communication and is thought to…”
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Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice by Eid, Stéphanie A, El Massry, Mohamed, Hichor, Mehdi, Haddad, Mary, Grenier, Julien, Dia, Batoul, Barakat, Rasha, Boutary, Suzan, Chanal, Johan, Aractingi, Selim, Wiesel, Philippe, Szyndralewiez, Cédric, Azar, Sami T, Boitard, Christian, Zaatari, Ghazi, Eid, Assaad A, Massaad, Charbel

“…Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This…”
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Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice by Yet, S F, Perrella, M A, Layne, M D, Hsieh, C M, Maemura, K, Kobzik, L, Wiesel, P, Christou, H, Kourembanas, S, Lee, M E

“…Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates…”
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Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice by WIESEL, Philippe, PATEL, Anand P, YET, Shaw-Fang, LEE, Mu-En, PERRELLA, Mark A, DIFONZO, Nicole, MARRIA, Pooja B, SIM, Chäng U, PELLACANI, Andrea, MAEMURA, Koji, LEBLANC, Brian W, MARINO, Kathryn, DOERSCHUK, Claire M

“…Heme oxygenase (HO)-1 is an enzyme that degrades heme to generate CO (a vasodilatory gas), iron, and the potent antioxidant bilirubin. A disease process…”
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Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice by Yet, Shaw-Fang, Perrella, Mark A., Layne, Matthew D., Hsieh, Chung-Ming, Maemura, Koji, Kobzik, Lester, Wiesel, Philippe, Christou, Helen, Kourembanas, Stella, Lee, Mu-En

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Down-regulation of High Mobility Group-I(Y) Protein Contributes to the Inhibition of Nitric-oxide Synthase 2 by Transforming Growth Factor-β1 by Pellacani, Andrea, Wiesel, Philippe, Razavi, Susan, Vasilj, Vedrana, Feinberg, Mark W., Chin, Michael T., Reeves, Raymond, Perrella, Mark A.

“…The inducible isoform of nitric-oxide synthase (NOS2) catalyzes the production of nitric oxide (NO), which participates in the pathophysiology of systemic…”
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Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-β1 by PELLACANI, A, WIESEL, P, SHARMA, A, FOSTER, L. C, HUGGINS, G. S, YET, S.-F, PERRELLA, M. A

“…Abstract —Heme oxygenase (HO)-1 generates CO, a gas with vasodilatory properties, during heme metabolism. HO-1 is expressed highly in vascular tissue after…”
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Role of activating protein‐1 and high mobility group‐I(Y) protein in the induction of CD44 gene expression by interleukin‐1β in vascular smooth muscle cells by Foster, Lauren C., Wiesel, Philippe, Huggins, Gordon S., Pañares, Rea, Chin, Michael T., Pellacani, Andrea, Perrella, Mark A.

“…ABSTRACT CD44 is a multifunctional cell adhesion molecule that participates in pathological states such as inflammation and tumorigenesis. CD44 is induced on…”
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Induction of Heme Oxygenase-1 During Endotoxemia Is Downregulated by Transforming Growth Factor-beta 1 by Pellacani, Andrea, Wiesel, Philippe, Sharma, Arunabh, Foster, Lauren C, Huggins, Gordon S, Yet, Shaw-Fang, Perrella, Mark A

“…Heme oxygenase (HO)-1 generates CO, a gas with vasodilatory properties, during heme metabolism. HO-1 is expressed highly in vascular tissue after endotoxin…”
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High Mobility Group-I(Y) Protein Facilitates Nuclear Factor-κB Binding and Transactivation of the Inducible Nitric-oxide Synthase Promoter/Enhancer by Perrella, Mark A., Pellacani, Andrea, Wiesel, Philippe, Chin, Michael T., Foster, Lauren C., Ibanez, Maureen, Hsieh, Chung-Ming, Reeves, Raymond, Yet, Shaw-Fang, Lee, Mu-En

“…Nitric oxide (NO), a free radical gas whose production is catalyzed by the enzyme NO synthase, participates in the regulation of multiple organ systems. The…”
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Exacerbation of chronic renovascular hypertension adn acute renal failure in heme oxygenase-1-deficient mice by Wiesel, Philippe, Patel, Anand P, Carvajal, Irvith M, Zhi Yuan Wang

“…Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to generate carbon monoxide (a vasodilatory gas that has anti-inflammatory…”
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