Search Results - "Wiese, Claudia"

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination by Zhao, Weixing, Wiese, Claudia, Kwon, Youngho, Hromas, Robert, Sung, Patrick

“…Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast, ovarian, and other cancers. The BRCA-encoded products form complexes with…”
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Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis by Pires, Elena, Sung, Patrick, Wiese, Claudia

“…[Display omitted] •RAD51AP1 is a DNA-binding protein that stimulates RAD51 activity.•RAD51AP1 protects against DNA damage and is required for replication fork…”
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DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response by Liang, Fengshan, Miller, Adam S., Longerich, Simonne, Tang, Caroline, Maranon, David, Williamson, Elizabeth A., Hromas, Robert, Wiese, Claudia, Kupfer, Gary M., Sung, Patrick

“…Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer susceptibility stemming from a failure to remove DNA crosslinks and other…”
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Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry by Zhao, Weixing, Vaithiyalingam, Sivaraja, San Filippo, Joseph, Maranon, David G., Jimenez-Sainz, Judit, Fontenay, Gerald V., Kwon, Youngho, Leung, Stanley G., Lu, Lucy, Jensen, Ryan B., Chazin, Walter J., Wiese, Claudia, Sung, Patrick

“…The tumor suppressor BRCA2 is thought to facilitate the handoff of ssDNA from replication protein A (RPA) to the RAD51 recombinase during DNA break and…”
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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation by Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S., Katz, Jeffrey N., Rogers, Cody M., Neal, Francisco E., Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K., Joel, Marina Z., Lu, Lucy, Holloway, Stephen P., Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

“…The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication…”
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NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability by Parplys, Ann C, Zhao, Weixing, Sharma, Neelam, Groesser, Torsten, Liang, Fengshan, Maranon, David G, Leung, Stanley G, Grundt, Kirsten, Dray, Eloïse, Idate, Rupa, Østvold, Anne Carine, Schild, David, Sung, Patrick, Wiese, Claudia

“…NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) is a 27 kD chromosomal, vertebrate-specific protein, for which limited functional data…”
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Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex by Liang, Fengshan, Longerich, Simonne, Miller, Adam S., Tang, Caroline, Buzovetsky, Olga, Xiong, Yong, Maranon, David G., Wiese, Claudia, Kupfer, Gary M., Sung, Patrick

“…The UAF1-USP1 complex deubiquitinates FANCD2 during execution of the Fanconi anemia DNA damage response pathway. As such, UAF1 depletion results in persistent…”
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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing by Zhao, Weixing, Steinfeld, Justin B., Liang, Fengshan, Chen, Xiaoyong, Maranon, David G., Jian Ma, Chu, Kwon, Youngho, Rao, Timsi, Wang, Weibin, Sheng, Chen, Song, Xuemei, Deng, Yanhong, Jimenez-Sainz, Judit, Lu, Lucy, Jensen, Ryan B., Xiong, Yong, Kupfer, Gary M., Wiese, Claudia, Greene, Eric C., Sung, Patrick

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Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 by Galkin, Vitold E, Etchin, Julia, Egelman, Edward, Yu, Xiong, Schild, David, Chen, Junjie, Wiese, Claudia, Williams, Gareth J, Sy, Shirley M-H, Sung, Patrick, Tsai, Miaw-Sheue, Dray, Eloïse, Saro, Dorina, Hammel, Michal, Liu, Dongqing

“…Tumor suppressor PALB2 is known to interact with BRCA1 and BRCA2, and to be required for the latter's localization to sites of DNA damage. Now PALB2 is shown…”
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Homologous Recombination Contributes to the Repair of DNA Double-Strand Breaks Induced by High-Energy Iron Ions by Zafar, Faria, Seidler, Sara B., Kronenberg, Amy, Schild, David, Wiese, Claudia

“…To test the contribution of homologous recombinational repair (HRR) in repairing DNA damage sites induced by high-energy iron ions, we used (1) HRR-deficient…”
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Dynamin impacts homology-directed repair and breast cancer response to chemotherapy by Chernikova, Sophia B, Nguyen, Rochelle B, Truong, Jessica T, Mello, Stephano S, Stafford, Jason H, Hay, Michael P, Olson, Andrew, Solow-Cordero, David E, Wood, Douglas J, Henry, Solomon, von Eyben, Rie, Deng, Lei, Gephart, Melanie Hayden, Aroumougame, Asaithamby, Wiese, Claudia, Game, John C, Győrffy, Balázs, Brown, J Martin

“…After the initial responsiveness of triple-negative breast cancers (TNBCs) to chemotherapy, they often recur as chemotherapy-resistant tumors, and this has…”
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RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination by Selemenakis, Platon, Sharma, Neelam, Uhrig, Mollie E, Katz, Jeffrey, Kwon, Youngho, Sung, Patrick, Wiese, Claudia

“…Homologous recombination DNA repair (HR) is a complex DNA damage repair pathway and an attractive target of inhibition in anti-cancer therapy. To help guide…”
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Promotion of Homologous Recombination and Genomic Stability by RAD51AP1 via RAD51 Recombinase Enhancement by Wiese, Claudia, Dray, Eloïse, Groesser, Torsten, San Filippo, Joseph, Shi, Idina, Collins, David W., Tsai, Miaw-Sheue, Williams, Gareth J., Rydberg, Bjorn, Sung, Patrick, Schild, David

“…Homologous recombination (HR) repairs chromosome damage and is indispensable for tumor suppression in humans. RAD51 mediates the DNA strand-pairing step in HR…”
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Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1) by Dray, Eloïse, Dunlop, Myun Hwa, Kauppi, Liisa, Filippo, Joseph San, Wiese, Claudia, Tsai, Miaw-Sheue, Begovic, Sead, Schild, David, Jasin, Maria, Keeney, Scott, Sung, Patrick

“…Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 associated protein 1) has…”
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Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability by Schild, David, Wiese, Claudia

“…RAD51, a key protein in the homologous recombinational DNA repair (HRR) pathway, is the major strand-transferase required for mitotic recombination. An…”
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NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes by Østvold, Anne Carine, Grundt, Kirsten, Wiese, Claudia

“…The Nuclear Casein and Cyclin-dependent Kinase Substrate 1 (NUCKS1) protein is highly conserved in vertebrates, predominantly localized to the nucleus and one…”
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Abstract 2569: Synergism between RAD51AP1 and RAD54 during late stages of homologous recombination DNA repair by Selemenakis, Platon, Maranon, David, Wiese, Claudia

“…Abstract Genomic instability is one of the enabling hallmarks of cancer and can arise by exposure to several factors: endogenous challenges such as stress to…”
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Abstract 1850 The Association between Tumor Suppressor BRCA2 and DNA in Maintaining Genome Integrity by Kwon, Youngho, Neal, Francisco, Li, Wenjing, Zahid, Shahrez, Zhao, Weixing, Wiese, Claudia, Sung, Patrick

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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing by Zhao, Weixing, Steinfeld, Justin B., Liang, Fengshan, Chen, Xiaoyong, Maranon, David G., Jian Ma, Chu, Kwon, Youngho, Rao, Timsi, Wang, Weibin, Sheng, Chen, Song, Xuemei, Deng, Yanhong, Jimenez-Sainz, Judit, Lu, Lucy, Jensen, Ryan B., Xiong, Yong, Kupfer, Gary M., Wiese, Claudia, Greene, Eric C., Sung, Patrick

“…The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1–BARD1…”
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Toward A variable RBE for proton beam therapy by Willers, Henning, Allen, Antino, Grosshans, David, McMahon, Stephen J., von Neubeck, Cläre, Wiese, Claudia, Vikram, Bhadrasain

“…In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological effectiveness (RBE) of 1.1 compared to photons in human cancers…”
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