Search Results - "Wiersinga, W."

The immunology of sepsis by van der Poll, Tom, Shankar-Hari, Manu, Wiersinga, W. Joost

“…Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not…”
Get full text

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review by Wiersinga, W. Joost, Rhodes, Andrew, Cheng, Allen C, Peacock, Sharon J, Prescott, Hallie C

“…IMPORTANCE: The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a…”
Get full text

Melioidosis by Wiersinga, W. Joost, Currie, Bart J, Peacock, Sharon J

“…Melioidosis, most common in Southeast Asia and northern Australia, is caused by the environmental gram-negative bacillus Burkholderia pseudomallei. This review…”
Get full text

Immunopathophysiology of human sepsis by Wiersinga, W. Joost, van der Poll, Tom

“…Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality worldwide. The most recent consensus defines sepsis as life-threatening…”
Get full text

The power of the gut in critical care by Wiersinga, W. Joost

Get full text

A guide to immunotherapy for COVID-19 by van de Veerdonk, Frank L., Giamarellos-Bourboulis, Evangelos, Pickkers, Peter, Derde, Lennie, Leavis, Helen, van Crevel, Reinout, Engel, Job J., Wiersinga, W. Joost, Vlaar, Alexander P. J., Shankar-Hari, Manu, van der Poll, Tom, Bonten, Marc, Angus, Derek C., van der Meer, Jos W. M., Netea, Mihai G.

“…Immune dysregulation is an important component of the pathophysiology of COVID-19. A large body of literature has reported the effect of immune-based therapies…”
Get full text

Muscle abnormalities worsen after post-exertional malaise in long COVID by Appelman, Brent, Charlton, Braeden T., Goulding, Richie P., Kerkhoff, Tom J., Breedveld, Ellen A., Noort, Wendy, Offringa, Carla, Bloemers, Frank W., van Weeghel, Michel, Schomakers, Bauke V., Coelho, Pedro, Posthuma, Jelle J., Aronica, Eleonora, Joost Wiersinga, W., van Vugt, Michèle, Wüst, Rob C. I.

“…A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is…”
Get full text

The pathophysiology of sepsis and precision-medicine-based immunotherapy by Giamarellos-Bourboulis, Evangelos J., Aschenbrenner, Anna C., Bauer, Michael, Bock, Christoph, Calandra, Thierry, Gat-Viks, Irit, Kyriazopoulou, Evdoxia, Lupse, Mihaela, Monneret, Guillaume, Pickkers, Peter, Schultze, Joachim L., van der Poll, Tom, van de Veerdonk, Frank L., Vlaar, Alexander P. J., Weis, Sebastian, Wiersinga, W. Joost, Netea, Mihai G.

“…Sepsis remains a major cause of morbidity and mortality in both low- and high-income countries. Antibiotic therapy and supportive care have significantly…”
Get full text

Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis by Haak, Bastiaan W, Prescott, Hallie C, Wiersinga, W Joost

“…Alongside advances in understanding the pathophysiology of sepsis, there have been tremendous strides in understanding the pervasive role of the gut microbiota…”
Get full text

Host-pathogen interaction in invasive Salmonellosis by de Jong, Hanna K, Parry, Chris M, van der Poll, Tom, Wiersinga, W Joost

“…Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is…”
Get full text

Uncovering hidden antimicrobial resistance patterns within the hospital microbiome by Haak, Bastiaan W., Wiersinga, W. Joost

“…Combined culture-dependent and culture-independent metagenomic sequencing methods reveal the pervasive and long-lasting presence of antimicrobial resistance…”
Get full text

Impact of antimicrobial therapy on the gut microbiome by Bhalodi, Amira A, van Engelen, Tjitske S R, Virk, Harjeet S, Wiersinga, W Joost

“…Abstract The gut microbiome is now considered an organ unto itself and plays an important role in health maintenance and recovery from critical illness. The…”
Get full text

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 by Evans, Laura, Rhodes, Andrew, Alhazzani, Waleed, Antonelli, Massimo, Coopersmith, Craig M., French, Craig, Machado, Flávia R., Mcintyre, Lauralyn, Ostermann, Marlies, Prescott, Hallie C., Schorr, Christa, Simpson, Steven, Wiersinga, W. Joost, Alshamsi, Fayez, Angus, Derek C., Arabi, Yaseen, Azevedo, Luciano, Beale, Richard, Beilman, Gregory, Belley-Cote, Emilie, Burry, Lisa, Cecconi, Maurizio, Centofanti, John, Coz Yataco, Angel, De Waele, Jan, Dellinger, R. Phillip, Doi, Kent, Du, Bin, Estenssoro, Elisa, Ferrer, Ricard, Gomersall, Charles, Hodgson, Carol, Møller, Morten Hylander, Iwashyna, Theodore, Jacob, Shevin, Kleinpell, Ruth, Klompas, Michael, Koh, Younsuck, Kumar, Anand, Kwizera, Arthur, Lobo, Suzana, Masur, Henry, McGloughlin, Steven, Mehta, Sangeeta, Mehta, Yatin, Mer, Mervyn, Nunnally, Mark, Oczkowski, Simon, Osborn, Tiffany, Papathanassoglou, Elizabeth, Perner, Anders, Puskarich, Michael, Roberts, Jason, Schweickert, William, Seckel, Maureen, Sevransky, Jonathan, Sprung, Charles L., Welte, Tobias, Zimmerman, Janice, Levy, Mitchell

Get full text

Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis by Wiersinga, W. Joost, van Agtmael, Michiel A

Get full text

Author Correction: Uncovering hidden antimicrobial resistance patterns within the hospital microbiome by Haak, Bastiaan W., Wiersinga, W. Joost

“…A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-0919-z…”
Get full text

Artificial Intelligence for Early Sepsis Detection: A Word of Caution by Schinkel, Michiel, van der Poll, Tom, Wiersinga, W Joost

“…Schinkel et al discuss the use of artificial intelligence for early detection of sepsis. Sepsis is a life-threatening syndrome with an estimated 49 million…”
Get full text

The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy by Bartalena, L, Kahaly, G J, Baldeschi, L, Dayan, C M, Eckstein, A, Marcocci, C, Marinò, M, Vaidya, B, Wiersinga, W M

“…Graves’ orbitopathy (GO) is the main extrathyroidal manifestation of Graves’ disease (GD). Choice of treatment should be based on the assessment of clinical…”
Get full text

What Is COVID-19? by Wiersinga, W. Joost, Prescott, Hallie C

Get full text

A call to action: time to recognise melioidosis as a neglected tropical disease by Savelkoel, Jelmer, Dance, David A B, Currie, Bart J, Limmathurotsakul, Direk, Wiersinga, W Joost

“…Melioidosis is a tropical infection caused by the soil bacterium Burkholderia pseudomallei. Despite the substantial impact of this often overlooked pathogen on…”
Get full text

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability by Brouwer, Philip J M, Caniels, Tom G, van der Straten, Karlijn, Snitselaar, Jonne L, Aldon, Yoann, Bangaru, Sandhya, Torres, Jonathan L, Okba, Nisreen M A, Claireaux, Mathieu, Kerster, Gius, Bentlage, Arthur E H, van Haaren, Marlies M, Guerra, Denise, Burger, Judith A, Schermer, Edith E, Verheul, Kirsten D, van der Velde, Niels, van der Kooi, Alex, van Schooten, Jelle, van Breemen, Mariëlle J, Bijl, Tom P L, Sliepen, Kwinten, Aartse, Aafke, Derking, Ronald, Bontjer, Ilja, Kootstra, Neeltje A, Wiersinga, W Joost, Vidarsson, Gestur, Haagmans, Bart L, Ward, Andrew B, de Bree, Godelieve J, Sanders, Rogier W, van Gils, Marit J

“…The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a large impact on global health, travel, and economy. Therefore,…”
Get full text