Search Results - "Wierenga, Annet F"

Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis by van Langelaar, Jamie, Rijvers, Liza, Janssen, Malou, Wierenga‐Wolf, Annet F., Melief, Marie‐José, Siepman, Theodora A., de Vries, Helga E., Unger, Peter‐Paul A., van Ham, S. Marieke, Hintzen, Rogier Q., van Luijn, Marvin M.

“…Objective Results from anti‐CD20 therapies demonstrate that B‐ and T‐cell interaction is a major driver of multiple sclerosis (MS). The local presence of…”
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The association of Epstein‐Barr virus infection with CXCR3+ B‐cell development in multiple sclerosis: impact of immunotherapies by Langelaar, Jamie, Wierenga‐Wolf, Annet F., Samijn, Johnny P.A., Luijks, Caroline J.M., Siepman, Theodora A., Doorn, Pieter A., Bell, Andrew, Zelm, Menno C., Smolders, Joost, Luijn, Marvin M.

“…Epstein–Barr virus (EBV) infection of B cells is associated with increased multiple sclerosis (MS) susceptibility. Recently, we found that CXCR3‐expressing B…”
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Differential Runx3, Eomes, and T‐bet expression subdivides MS‐associated CD4+ T cells with brain‐homing capacity by Hoeks, Cindy, Puijfelik, Fabiënne van, Koetzier, Steven C., Rip, Jasper, Corsten, Cato E.A., Wierenga‐Wolf, Annet F., Melief, Marie‐José, Stinissen, Piet, Smolders, Joost, Hellings, Niels, Broux, Bieke, Luijn, Marvin M.

“…Multiple sclerosis (MS) is a common and devastating chronic inflammatory disease of the CNS. CD4+ T cells are assumed to be the first to cross the…”
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Chemical and genetic control of IFNγ‐induced MHCII expression by Wijdeven, Ruud H, van Luijn, Marvin M, Wierenga‐Wolf, Annet F, Akkermans, Jimmy J, van den Elsen, Peter J, Hintzen, Rogier Q, Neefjes, Jacques

“…The cytokine interferon‐γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4 + T cells…”
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The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis by Rijvers, Liza, Melief, Marie‐José, der Vuurst de Vries, Roos M., Stéphant, Maeva, Langelaar, Jamie, Wierenga‐Wolf, Annet F., Hogervorst, Jeanet M., Geurts‐Moespot, Anneke J., Sweep, Fred C. G. J., Hintzen, Rogier Q., Luijn, Marvin M.

“…In MS, B cells survive peripheral tolerance checkpoints to mediate local inflammation, but the underlying molecular mechanisms are relatively underexplored. In…”
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Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis by van Zwam, Marloes, Huizinga, Ruth, Heijmans, Nicole, van Meurs, Marjan, Wierenga-Wolf, Annet F, Melief, Marie-José, Hintzen, Rogier Q, 't Hart, Bert A, Amor, Sandra, Boven, Leonie A, Laman, Jon D

“…Despite lack of classical lymphatic vessels in the central nervous system (CNS), cells and antigens do reach the CNS-draining lymph nodes. These lymph nodes…”
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Pregnancy-induced effects on memory B-cell development in multiple sclerosis by Janssen, Malou, Rijvers, Liza, Koetzier, Steven C., Wierenga-Wolf, Annet F., Melief, Marie-José, van Langelaar, Jamie, Runia, Tessel F., de Groot, Christianne J. M., Neuteboom, Rinze, Smolders, Joost, van Luijn, Marvin M.

“…In MS, pathogenic memory B cells infiltrate the brain and develop into antibody-secreting cells. Chemokine receptors not only define their brain-infiltrating…”
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Improving Glucocorticoid Sensitivity of Brain-Homing CD4 + T Helper Cells by Steroid Hormone Crosstalk by Koetzier, Steven C, van Langelaar, Jamie, Wierenga-Wolf, Annet F, Melief, Marie-José, Pol, Kim, Musters, Suzanne, Lubberts, Erik, Dik, Willem A, Smolders, Joost, van Luijn, Marvin M

“…In early multiple sclerosis (MS), an IFN-γ GM-CSF IL-17 CD4 T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central…”
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Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis by van Luijn, Marvin M, Kreft, Karim L, Jongsma, Marlieke L, Mes, Steven W, Wierenga-Wolf, Annet F, van Meurs, Marjan, Melief, Marie-José, der Kant, Rik van, Janssen, Lennert, Janssen, Hans, Tan, Rusung, Priatel, John J, Neefjes, Jacques, Laman, Jon D, Hintzen, Rogier Q

“…C-type lectins are key players in immune regulation by driving distinct functions of antigen-presenting cells. The C-type lectin CLEC16A gene is located at…”
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Myelin ingestion alters macrophage antigen-presenting function in vitro and in vivo by Zwam, Marloes, Samsom, Janneke N., Nieuwenhuis, Edward E., Melief, Marie‐José, Wierenga‐Wolf, Annet F., Dijke, I. Esmé, Talens, Simone, Meurs, Marjan, Voerman, Jane S., Boven, Leonie A., Laman, Jon D.

“…Macrophage myelin ingestion results in a population of macrophages that induces T‐cell proliferation, restricts detrimental Th1 differentiation, and suppresses…”
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Effector T Helper Cells Are Selectively Controlled During Pregnancy and Related to a Postpartum Relapse in Multiple Sclerosis by Koetzier, Steven C, Neuteboom, Rinze F, Wierenga-Wolf, Annet F, Melief, Marie-José, de Mol, C Louk, van Rijswijk, Angelique, Dik, Willem A, Broux, Bieke, van der Wal, Ronald, van den Berg, Sjoerd A A, Smolders, Joost, van Luijn, Marvin M

“…Multiple sclerosis (MS) patients are protected from relapses during pregnancy and have an increased relapse risk after delivery. It is unknown how pregnancy…”
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Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib by Rijvers, Liza, van Langelaar, Jamie, Bogers, Laurens, Melief, Marie-José, Koetzier, Steven C., Blok, Katelijn M., Wierenga-Wolf, Annet F., de Vries, Helga E., Rip, Jasper, Corneth, Odilia B.J., Hendriks, Rudi W., Grenningloh, Roland, Boschert, Ursula, Smolders, Joost, van Luijn, Marvin M.

“…Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple…”
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Distinct Effector Programs of Brain-Homing CD8 + T Cells in Multiple Sclerosis by Koetzier, Steven C, van Langelaar, Jamie, Melief, Marie-José, Wierenga-Wolf, Annet F, Corsten, Cato E A, Blok, Katelijn M, Hoeks, Cindy, Broux, Bieke, Wokke, Beatrijs, van Luijn, Marvin M, Smolders, Joost

“…The effector programs of CD8 memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8…”
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Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes by Wong, Yu Yi M, Bruijstens, Arlette L, Barro, Christian, Michalak, Zuzanna, Melief, Marie-José, Wierenga, Annet F, van Pelt, E Daniëlle, Neuteboom, Rinze F, Kuhle, Jens, Hintzen, Rogier Q

“…OBJECTIVETo explore the correlation between serum and CSF neurofilament light chain (NfL) and the association of NfL levels and future disease activity in…”
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Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin by BOUMA, Gerben, LAM-TSE, Wai Kwan, WIERENGA-WOLF, Annet F, DREXHAGE, Hemmo A, VERSNEL, Marjan A

“…Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin…”
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T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes by Wong, Yu Yi M, van der Vuurst de Vries, Roos M, van Pelt, E Daniëlle, Ketelslegers, Immy A, Melief, Marie-José, Wierenga, Annet F, Catsman-Berrevoets, Coriene E, Neuteboom, Rinze F, Hintzen, Rogier Q

“…Background: Cerebrospinal fluid (CSF) levels of T-cell activation marker soluble CD27 (sCD27) are associated with subsequent disease activity after a first…”
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T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention by van Langelaar, Jamie, van der Vuurst de Vries, Roos M, Janssen, Malou, Wierenga-Wolf, Annet F, Spilt, Isis M, Siepman, Theodora A, Dankers, Wendy, Verjans, Georges M G M, de Vries, Helga E, Lubberts, Erik, Hintzen, Rogier Q, van Luijn, Marvin M

“…CD4+ T helper 17 (Th17) cells are key regulators of multiple sclerosis disease activity, but functionally heterogeneous. Van Langelaar et al. report that…”
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Role of CD8 regulatory T-cells in multiple sclerosis by Kreft, Karim L., Verbraak, Evert, Wierenga-Wolf, Annet F., Laman, Jon D., Hintzen, Rogier Q.

“…No abstract is available for this article…”
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Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis by Bogers, Laurens, Rip, Jasper, Rijvers, Liza, van Langelaar, Jamie, Koetzier, Steven C., Kuiper, Kirsten L., Meerdink, Veronique, Wierenga-Wolf, Annet F., Melief, Marie-José, Marques, Ana M., Smolders, Joost, van Luijn, Marvin M.

“…B cells of people with multiple sclerosis (MS) are more responsive to IFN-γ, corresponding to their brain-homing potential. We studied how a coding single…”
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The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway by Rijvers, Liza, Melief, Marie-José, van Langelaar, Jamie, van der Vuurst de Vries, Roos M, Wierenga-Wolf, Annet F, Koetzier, Steven C, Priatel, John J, Jorritsma, Tineke, van Ham, S Marieke, Hintzen, Rogier Q, van Luijn, Marvin M

“…C-type lectin is located next to , the master transcription factor of HLA class II (HLA-II), at a susceptibility locus for several autoimmune diseases,…”
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