Search Results - "Wier, WG"

Spontaneous synchronous synaptic calcium transients in cultured cortical neurons by Murphy, TH, Blatter, LA, Wier, WG, Baraban, JM

“…The firing pattern displayed by neuronal aggregates is thought to play a key role in cortical development and physiology. In this study, we have employed…”
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Different roles of ryanodine receptors and inositol (1,4,5)-trisphosphate receptors in adrenergically stimulated contractions of small arteries by Lamont, Christine, Wier, W Gil

“…The functions of ryanodine receptors (RyRs) and inositol (1,4,5)-trisphosphate receptors [Ins(1,4,5)P(3)Rs] in adrenergically activated contractions of…”
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Evoked and Spontaneous Purinergic Junctional Ca2+ Transients (jCaTs) in Rat Small Arteries by Lamont, Christine, Wier, W Gil

“…Confocal microscopy of fluo-4 fluorescence in pressurized rat mesenteric small arteries subjected to low-frequency electrical field stimulation revealed Ca…”
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Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission by Murphy, TH, Blatter, LA, Bhat, RV, Fiore, RS, Wier, WG, Baraban, JM

“…Calcium/calmodulin-dependent protein kinase II (CaMK) and p42 mitogen-activated protein kinase (MAPK) are enriched in neurons and possess the capacity to…”
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Ca2+ Release Mechanisms, Ca2+ Sparks, and Local Control of Excitation-Contraction Coupling in Normal Heart Muscle by Wier, Withrow Gil, Balke, C William

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Purinergic and adrenergic Ca2+ transients during neurogenic contractions of rat mesenteric small arteries by Lamont, Christine, Vainorius, Enrikas, Wier, W. Gil

“…Contraction of small arteries is regulated by the sympathetic nervous system, but the Ca 2+ transients during neurally stimulated contraction of intact small…”
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Role of the Transverse-Axial Tubule System in Generating Calcium Sparks and Calcium Transients in Rat Atrial Myocytes by Kirk, Malcolm M., Izu, Leighton T., Chen‐Izu, Ye, McCulle, Stacey L., Wier, W. Gil, Balke, C. William, Shorofsky, Stephen R.

“…Cardiac atrial cells lack a regular system of transverse tubules like that in cardiac ventricular cells. Nevertheless, many atrial cells do possess an…”
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Local Calcium Transients Triggered by Single L-Type Calcium Channel Currents in Cardiac Cells by López-López, José Ramón, Shacklock, Philip S., Balke, C. William, Wier, Withrow Gil

“…Excitation-contraction coupling was studied in mammalian cardiac cells in which the opening probability of L-type calcium (Ca$^{2+}$) channels was reduced…”
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Essential role of EDHF in the initiation and maintenance of adrenergic vasomotion in rat mesenteric arteries by Mauban, Joseph R H, Wier, W Gil

“…The possible roles of endothelial intracellular Ca(2+) concentration ([Ca(2+)](i)), nitric oxide (NO), arachidonic acid (AA) metabolites, and Ca(2+)-activated…”
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Evolution of Cardiac Calcium Waves from Stochastic Calcium Sparks by Izu, Leighton T., Wier, W. Gil, Balke, C. William

“…We present a model that provides a unified framework for studying Ca 2+ sparks and Ca 2+ waves in cardiac cells. The model is novel in combining 1) use of…”
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Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle by Ji, Guangju, Feldman, Morris E, Deng, Ke-Yu, Greene, Kai Su, Wilson, Jason, Lee, Jane C, Johnston, Robyn C, Rishniw, Mark, Tallini, Yvonne, Zhang, Jin, Wier, Winthrop G, Blaustein, Mordecai P, Xin, Hong-Bo, Nakai, Junichi, Kotlikoff, Michael I

“…Genetically encoded signaling proteins provide remarkable opportunities to design and target the expression of molecules that can be used to report critical…”
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Ca2+ sparks involving multiple Ca2+ release sites along Z-lines in rat heart cells by Parker, I, Zang, W J, Wier, W G

“…1. High spatial resolution confocal imaging was used to investigate the fundamental nature of "Ca2+ sparks' in rat cardiac myocytes loaded with the fluorescent…”
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Large currents generate cardiac Ca2+ sparks by Izu, L T, Mauban, J R, Balke, C W, Wier, W G

“…Previous models of cardiac Ca2+ sparks have assumed that Ca2+ currents through the Ca2+ release units (CRUs) were approximately 1-2 pA, producing sparks with…”
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Mg2+ blocks myogenic tone but not K+-induced constriction: role for SOCs in small arteries by Zhang, Jin, Wier, W Gil, Blaustein, Mordecai P

“…The effects of Mg(2+) and nifedipine (Nif) on vasoconstriction and Ca(2+) transients were studied in intact, pressurized rat mesenteric arteries with myogenic…”
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Cellular Mechanisms of Altered Contractility in the Hypertrophied Heart: Big Hearts, Big Sparks by Shorofsky, Stephen R, Aggarwal, Rajesh, Corretti, Mary, Baffa, Jeanne M, Strum, Judy M, Al-Seikhan, Badr A, Kobayashi, Yvonne M, Jones, Larry R, Wier, W. Gil, Balke, C. William

“…To investigate the cellular mechanisms for altered Ca homeostasis and contractility in cardiac hypertrophy, we measured whole-cell L-type Ca currents (ICa,L),…”
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Local and cellular Ca2+ transients in smooth muscle of pressurized rat resistance arteries during myogenic and agonist stimulation by Miriel, Victor A., Mauban, Joseph R. H., Blaustein, Mordecai P., Gil Wier, W.

“…Confocal laser scanning microscopy was used to visualize Ca 2+ transients in the vascular smooth muscle cells (VSMC) of intact, pressurized rat mesenteric…”
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Local Ca2+ transients (Ca2+ sparks) originate at transverse tubules in rat heart cells by Shacklock, P S, Wier, W G, Balke, C W

“…1. The origins of local [Ca2+]i transients (Ca2+ sparks) were studied using dual-channel confocal laser scanning microscopy. Line scan images showing [Ca2+]i…”
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Graded α-adrenoceptor activation of arteries involves recruitment of smooth muscle cells to produce ‘all or none’ Ca2+signals by Zang, W.-J., Balke, C.W., Wier, W.G.

“…Confocal laser scanning microscopy and Fluo-4 were used to visualize Ca2+transients within individual smooth muscle cells (SMC) of rat resistance arteries…”
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Local control of excitation-contraction coupling in rat heart cells by Wier, W G, Egan, T M, López‐López, J R, Balke, C W

“…1. Cytosolic free calcium ion concentration ([Ca2+]i) and whole-cell L-type Ca2+ channel currents were measured during excitation-contraction (E-C) coupling in…”
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Cytoplasmic [Ca2+] in mammalian ventricle : dynamic control by cellular processes by WIER, W. G

“…A quantitative reconstruction of [Ca2+]i transients is the desired goal, but that goal has yet to be reached. It will be reached by solving Equation 2., once…”
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