Search Results - "Wienke, Sara"

33 Blood-based tumor mutation burden (bTMB) predicts response to immune checkpoint blockade-based combination therapy (ICBC) in advanced non-small cell lung cancer (NSCLC): a real-world (RW) analysis by Gordon, Sean, Pellini, Bruna, Barnett, Reagan, Liao, Jiemin, Quinn, Katie, Wienke, Sara, Drusbosky, Leylah, Zhang, Nicole, Lefterova, Martina, Lawrence, Lauren, Kiedrowski, Lesli, Eppler, Ross, Odegaard, Justin, Chuang, Han-Yu

“…BackgroundStudies have shown that high TMB (≥10mut/MB on tissue) across solid tumors is associated with improved overall survival (OS) in patients (pts)…”
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Keeping Secrets or Educating Others: A Dyadic Analysis of Group Entitativity's Influence on Spouses' Label Management Connected to AATD by Smith, Rachel A., Parrott, Roxanne L., Wienke, Sara E.

“…In 1963, Goffman argued that forming a group based on shared stigma may provide benefits. However, there is no empirical research on whether perception that a…”
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Classifying Married Adults Diagnosed With Alpha-1 Antitrypsin Deficiency Based on Spousal Communication Patterns Using Latent Class Analysis: Insights for Intervention by Smith, Rachel A., Wienke, Sara E., Baker, Michelle K.

“…Married adults are increasingly exposed to test results that indicate an increased genetic risk for adult-onset conditions. For example, a SERPINA1 mutation,…”
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Abstract 406: Characterization of whole genome duplication in a genomic cohort of over 14000 cell free DNA samples by Gross, Andrew, Wang, Hao, Tolkunov, Denis, Jenkins, Colby, Wienke, Sara, Barbacioru, Catalin, Chuang, Han-Yu

“…Abstract Background: Wide-scale rates of whole genome duplication (WGD) have previously been demonstrated in studies performed in tissue among genomically…”
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Expanded carrier screening panels—does bigger mean better? by Wienke, Sara, Brown, Kimberly, Farmer, Meagan, Strange, Charlie

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Somatic Testing and Germline Genetic Status: Implications for Cancer Treatment Decisions and Genetic Counseling by Swan, Kelli, Dougherty, Kali Chatham, Myers, Sara Wienke

“…Purpose of Review We review recent precision oncology literature pertaining to the implications of germline and somatic genetic information in cancer…”
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Oncogene Overlap Analysis of Circulating Cell-free Tumor DNA to Explore the Appropriate Criteria for Defining MET Copy Number–Driven Lung Cancer by Tsui, David C.C., Drusbosky, Leylah M., Wienke, Sara, Gao, Dexiang, Bubie, Adrian, Barbacioru, Catalin, Camidge, D. Ross

“…Defining clinically relevant MET amplification levels in non-small cell lung cancer (NSCLC) remains challenging. We hypothesize that oncogene overlap and MET…”
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Abstract CT278: ERBB2 amplification detected in ctDNA as a surrogate for tumor tissue FISH analysis of HER2 status in a phase 1 study with zanidatamab for the treatment of locally advanced or metastatic HER2 expressing cancers by Shpektor, Diana, Dargahi, Daryanaz, Samiotakis, Antonios, Wienke, Sara, Livernois, Ali, Yablonovitch, Arielle, Yalamanchili, Geethika, Gartner, Elaina, Meric-Bernstam, Funda

“…Abstract Background: HER2-targeted therapies have substantially improved outcomes for patients with HER2-positive breast and gastric cancers. Several other…”
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Abstract 2490: Quantification of tumor fraction and outcomes association in a real-world non-small cell lung cancer (NSCLC) cohort using a tissue agnostic epigenomic circulating tumor DNA (ctDNA) assay by Wienke, Sara, Gordon, Sean, Liang, Samantha, Wang, Jing, Barnett, Reagan, Chang, Kyle, Zhang, Shile, Espenschied, Carin R., Quinn, Katie, Banks, Kimberly

“…Abstract Background: The validity of ctDNA assays for evaluating molecular response to therapy by measuring changes in variant allele fraction (VAF) while on…”
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Abstract 1052: Background variability in plasma ctDNA levels in patients with advanced lung cancer in the absence of treatment by Vega, Diana M., Markovets, Aleksandra, Abbosh, Christopher, Quinn, Katie, Chang, Kyle, Wienke, Sara, Hartmaier, Ryan, Hellmann, Matthew, Barrett, J Carl, Hodgson, Darren

“…Abstract Introduction: Molecular response (MR) is defined as a reduction in circulating tumor DNA (ctDNA) levels between baseline and early on-treatment…”
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Abstract 3123: A method for quantifying circulating tumor DNA level and molecular response using methylome sequencing by Chen, Sai, Quinn, Katie, Lee, Che-Yu, Zhao, Jun, Chang, Kyle, Jiang, Tingting, Zhang, Shile, Espenschied, Carin, Wienke, Sara, Rich, Thereasa, Wu, Indira, Kim, Yvonne, Liu, Xianxian, Alla, Nageswara, Ma, Dustin, Tran, Giao, Chuang, Han-Yu

“…Abstract Background: Circulating tumor DNA (ctDNA) level and the change in level at a subsequent time point (e.g. on-treatment change from baseline or…”
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Alpha-1 Couples: Interpersonal and Intrapersonal Predictors of Spousal Communication and Stress by Smith, Rachel A., Wienke, Sara, Coffman, Donna L.

“…Couples often discuss genetic test results, and then manage their implications together. This interdependence can lead to common, shared experiences, similar…”
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Genetics' influence on patient experiences with a rare chronic disorder: a photovoice study of living with alpha-1 antitrypsin deficiency by Williams, Pamela Holtzclaw, Shore, Lucinda, Sineath, Marvin, Quill, Jim, Warner, Barbara, Keith, Jamila, Walker, Deirdre, Wienke, Sara, Flavin, Susan, Strange, Charlie

“…Patients with rare chronic disorders and their caregivers increasingly form communities to support and exchange social experiences. Because up to 10% of the…”
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Genetics’ Influence on Patient Experiences with a Rare Chronic Disorder by Williams, Pamela Holtzclaw, Shore, Lucinda, Sineath, Marvin, Quill, Jim, Warner, Barbara, Keith, Jamila, Walker, Deirdre, Wienke, Sara, Flavin, Susan, Strange, Charlie

“…Patients with rare chronic disorders and their caregivers increasingly form communities to support and exchange social experiences. Because up to 10% of the…”
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