Search Results - "Wienhard, K."

The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph by Wienhard, K., Schmand, M., Casey, M.E., Baker, K., Bao, J., Eriksson, L., Jones, W.F., Knoess, C., Lenox, M., Lercher, M., Luk, P., Michel, C., Reed, J.H., Richerzhagen, N., Treffert, J., Vollmar, S., Young, J.W., Heiss, W.D., Nutt, R.

“…The ECAT HRRT is a three-dimensional (3-D) only dedicated brain tomograph employing the new scintillator lutetium-oxy-orthosilicate (LSO) and using depth of…”
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Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas by Jacobs, A, Voges, J, Reszka, R, Lercher, M, Gossmann, A, Kracht, L, Kaestle, Ch, Wagner, R, Wienhard, K, Heiss, WD

“…In clinical gene-therapy trials for recurrent glioblastomas, transduction of the herpes simplex virus type-1 thymidine kinase (HSV-1-tk) gene with subsequent…”
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Evaluation of an MR-compatible blood sampler for PET by Breuer, J, Grazioso, R, Zhang, N, Schmand, M, Wienhard, K

“…The integration of magnetic resonance imaging (MRI) and positron emission tomography (PET) is an upcoming hybrid imaging technique. Prototype scanners for…”
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PCA-Based Algorithm for Generation of Crystal Lookup Tables for PET Block Detectors by Breuer, J., Wienhard, K.

“…State-of-the-art data-acquisition systems for positron emission tomography (PET) block detectors use anger logic to determine preliminary 2-D coordinates of…”
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Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness by Eggers, C., Szelies, B., Bauer, B., Wienhard, K., Schröder, H., Herholz, K., Heiss, W.-D.

“…Positron emission tomography with 11C‐N‐methyl‐4‐piperidyl‐acetate (MP4A) was applied in eight healthy volunteers and two patients with mild Alzheimer's…”
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Performance results of a new DOI detector block for a high resolution PET-LSO research tomograph HRRT by Schmand, M., Eriksson, L., Casey, M.E., Andreaco, M.S., Melcher, C., Wienhard, K., Flugge, G., Nutt, R.

“…To improve the spatial resolution and uniformity in modern high resolution brain PET systems over the entire field of view (FOV), it is necessary to archive…”
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Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats by Heiss, W D, Graf, R, Wienhard, K, Löttgen, J, Saito, R, Fujita, T, Rosner, G, Wagner, R

“…Experimental models of focal cerebral ischemia have provided important data on early circulatory and biochemical changes, but typically their correspondence…”
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Progressive derangement of periinfarct viable tissue in ischemic stroke by Heiss, W D, Huber, M, Fink, G R, Herholz, K, Pietrzyk, U, Wagner, R, Wienhard, K

“…Sixteen patients were studied by multitracer positron emission tomography (PET) within 6-48 (mean of 23) h of onset of a hemispheric ischemic stroke and again…”
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PET-based molecular imaging in neuroscience by JACOBS, A. H, LI, H, MONFARED, P, KLEIN, M, VOLLMAR, S, BAUER, B, WAGNER, R, GRAF, R, WIENHARD, K, HERHOLZ, K, HEISS, W. D, WINKELER, A, HILKER, R, KNOESS, C, RÜGER, A, GALLDIKS, N, SCHALLER, B, SOBESKY, J, KRACHT, L

“…Positron emission tomography (PET) allows non-invasive assessment of physiological, metabolic and molecular processes in humans and animals in vivo. Advances…”
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The ECAT HRRT: NEMA NEC evaluation of the HRRT system, the new high-resolution research tomograph by Eriksson, L., Wienhard, K., Eriksson, M., Casey, M.E., Knoess, C., Bruckbauer, T., Hamill, J., Schmand, M., Gremillion, T., Lenox, M., Conti, M., Bendriem, B., Heiss, W.D., Nutt, R.

“…The ECAT HRRT (high-resolution research tomograph) is a three-dimensional(3-D)-only dedicated brain positron emission tomograph (PET) with LSO and GSO…”
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The ECAT EXACT HR: performance of a new high resolution positron scanner by Wienhard, K, Dahlbom, M, Eriksson, L, Michel, C, Bruckbauer, T, Pietrzyk, U, Heiss, W D

“…The ECAT EXACT HR is a newly designed CTI-Siemens PET scanner with high spatial resolution. Its physical performance with respect to resolution, count rate…”
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Quantitative Kinetics of [124I]FIAU in Cat and Man by Jacobs, Andreas, Braunlich, Ines, Graf, Rudolf, Lercher, Martin, Sakaki, Takayuki, Voges, Jurgen, Hesselmann, Volker, Brandau, Wolfgang, Wienhard, Klaus, Heiss, Wolf-Dieter

“…For the assessment of the efficacy of clinical gene therapy trials, different imaging modalities have been developed that enable a noninvasive assessment of…”
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Multi-modality imaging of uveal melanomas using combined PET/CT, high-resolution PET and MR imaging by Beyer, T, Pietrzyk, U, Knoess, C, Vollmar, S, Wienhard, K, Kracht, L, Bockisch, A, Maderwald, S, Kühl, H, Fitzek, M

“…We investigated the efficacy of combined FDG-PET/CT imaging for the diagnosis of small-size uveal melanomas and the feasibility of combining separate,…”
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Individual Functional Anatomy of Verb Generation by Herholz, K., Thiel, A., Wienhard, K., Pietrzyk, U., von Stockhausen, H.-M., Karbe, H., Kessler, J., Bruckbauer, T., Halber, M., Heiss, W.-D.

“…Examination of the individual functional anatomy of language is of particular interest in clinical neurology to explain the variability of aphasic symptoms…”
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Normal and pathological aging--findings of positron-emission-tomography by Mielke, R, Kessler, J, Szelies, B, Herholz, K, Wienhard, K, Heiss, W D

“…Normal aging of the brain is predominantly characterized by metabolic changes in the prefrontal cortex. While in middle age there is a trend to…”
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HeinzelCluster: accelerated reconstruction for FORE and OSEM3D by Vollmar, S, Michel, C, Treffert, J T, Newport, D F, Casey, M, Knöss, C, Wienhard, K, Liu, X, Defrise, M, Heiss, W D

“…Using iterative three-dimensional (3D) reconstruction techniques for reconstruction of positron emission tomography (PET) is not feasible on most…”
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In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism by HERHOLZ, K, BAUER, B, WIENHARD, K, KRACHT, L, MIELKE, R, LENZ, O, STROTMANN, T, HEISS, W.-D

“…Memory and attention are cognitive functions that depend heavily on the cholinergic system. Local activity of acetylcholine esterase (AChE) is an indicator of…”
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A new animal model of cerebral venous infarction: ligation of the posterior part of the superior sagittal sinus in the cat by Schaller, B, Graf, R, Wienhard, K, Heiss, W-D

“…Dural sinus occlusion is an infrequent but potentially devastating cause of stroke. The pathophysiological course of events underlying it is, as yet…”
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Advantages using pulse shape discrimination to assign the depth of interaction information (DOI) from a multi layer phoswich detector by Schmand, M., Eriksson, L., Casey, M.E., Wienhard, K., Flugge, G., Nutt, R.

“…Recently new high resolution brain PET and PET/SPECT tomographs have been discussed using phoswich detectors. The detector design is based on two layers of…”
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Imaging in gene therapy of patients with glioma by Jacobs, A H, Voges, J, Kracht, L W, Dittmar, C, Winkeler, A, Thomas, A, Wienhard, K, Herholz, K, Heiss, W D

“…Over 10 years ago, the first successful gene therapy paradigms for experimental brain tumors models have been conducted, and they were thought to revolutionize…”
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