Search Results - "Wiener, John"

New Inroads in the Treatment of Enuresis by Wiener, John S.

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The Next Step in Optimizing Sexual Health in Men Living With Spina Bifida: How Does Our Measurement Tool Measure Up? by Wiener, John S

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Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry by Damm-Ganamet, Kelly L, Arora, Nidhi, Becart, Stephane, Edwards, James P, Lebsack, Alec D, McAllister, Heather M, Nelen, Marina I, Rao, Navin L, Westover, Lori, Wiener, John J. M, Mirzadegan, Taraneh

“…At the onset of a drug discovery program, the goal is to identify novel compounds with appropriate chemical features that can be taken forward as lead series…”
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Commentary to "The natural (non-invasive) erection test: is it a reliable alternative to the artificial erection test?" by Wiener, John S

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Neurogenic Lower Urinary Tract Dysfunction by Wiener, John S., Chaudhry, Rajeev

“…Neurogenic lower urinary tract dysfunction (NLUTD) remains a formidable challenge to pediatric urologists to achieve the goals of renal preservation and the…”
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Commentary to ‘in-hospital resource utilization, outcome analysis and radiation exposure in children undergoing appendicostomy vs cecostomy tube placement’ by Wiener, John S.

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Spina Bifida Health-care Guidelines for Men's Health by Wiener, John S., Frimberger, Dominic C., Wood, Hadley

“…Spina bifida has traditionally been regarded as a pediatric health issue with little regard to adult consequences of the disorder. The congenital neurologic…”
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Surgeries and Health Outcomes Among Patients With Spina Bifida by Alabi, Noreen B, Thibadeau, Judy, Wiener, John S, Conklin, Mike J, Dias, Mark S, Sawin, Kathleen J, Valdez, Rodolfo

“…Patients with spina bifida (SB) typically develop serious secondary conditions and undergo surgical procedures related to neurologic disorders, orthopedic…”
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Urinary and Fecal Incontinence During Sexual Activity Is Common and Bothersome Among Adults With Spina Bifida by Roth, Joshua D., Hensel, Devon J., Wiener, John S., Younsi, Nina, Stein, Raimund, Misseri, Rosalia, Szymanski, Konrad M.

“…To evaluate the prevalence of and risk factors for urinary fecal incontinence (UI, FI) during sexual activity (UIS, FIS) among adults with spina bifida (SB)…”
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Bladder Management and Continence Outcomes in Adults with Spina Bifida: Results from the National Spina Bifida Patient Registry, 2009 to 2015 by Wiener, John S., Suson, Kristina D., Castillo, Jonathan, Routh, Jonathan C., Tanaka, Stacy T., Liu, Tiebin, Ward, Elisabeth A., Thibadeau, Judy K., Joseph, David B.

“…Most children with spina bifida now survive into adulthood, although most have neuropathic bladder with potential complications of incontinence, infection,…”
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Sexual Function and Dysfunction in Individuals with Spina Bifida: A Systematic Review by Hughes, Taylor L., Simmons, Kirsten L., Tejwani, Rohit, Barton, Karen D., Wiener, John S., Todd Purves, J., Routh, Jonathan C.

“…To conduct a systematic review of self-reported experiences of sexual function and dysfunction in individuals with spina bifida (SB). Medline, Embase, and Web…”
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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase by Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin

“…Bruton’s tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in…”
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What the editors are reading: Adolescent urology by Johnston, Ashley W., Caldamone, Anthony A., Wiener, John S.

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Education and employment as young adults living with spina bifida transition to adulthood in the USA: A study of the National Spina Bifida Patient Registry by Liu, Tiebin, Ouyang, Lijing, Walker, William O., Wiener, John S., Woodward, Jason, Castillo, Jonathan, Wood, Hadley M., Tanaka, Stacy T., Adams, Richard, Smith, Kathryn A., O'Neil, Joseph, Williams, Tonya R., Ward, Elisabeth A., Bowman, Robin M., Riley, Catharine

“…Aim To describe the education and employment transition experience of young adults with spina bifida (YASB) and investigate factors associated with employment…”
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Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida by Routh, Jonathan C, Cheng, Earl Y, Austin, J. Christopher, Baum, Michelle A, Gargollo, Patricio C, Grady, Richard W, Herron, Adrienne R, Kim, Steven S, King, Shelly J, Koh, Chester J, Paramsothy, Pangaja, Raman, Lisa, Schechter, Michael S, Smith, Kathryn A, Tanaka, Stacy T, Thibadeau, Judy K, Walker, William O, Wallis, M. Chad, Wiener, John S, Joseph, David B

“…Purpose Care of children with spina bifida has significantly advanced in the last half century, resulting in gains in longevity and quality of life for…”
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Scaffold Explorer: An Interactive Tool for Organizing and Mining Structure−Activity Data Spanning Multiple Chemotypes by Agrafiotis, Dimitris K, Wiener, John J. M

“…We introduce Scaffold Explorer, an interactive tool that allows medicinal chemists to define hierarchies of chemical scaffolds and use them to explore their…”
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Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity by Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P

“…Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given…”
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Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse by Eckert, William A., Wiener, John J.M., Cai, Hui, Ameriks, Michael K., Zhu, Jian, Ngo, Karen, Nguyen, Steven, Fung-Leung, Wai-Ping, Thurmond, Robin L., Grice, Cheryl, Edwards, James P., Chaplan, Sandra R., Karlsson, Lars, Sun, Siquan

“…Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS…”
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Contemporary epidemiological trends in complex congenital genitourinary anomalies by Lloyd, Jessica C, Wiener, John S, Gargollo, Patricio C, Inman, Brant A, Ross, Sherry S, Routh, Jonathan C

“…Anecdotal evidence suggests that complex congenital genitourinary anomalies are occurring less frequently. However, few epidemiological studies are available…”
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Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry by Liu, Tiebin, Ouyang, Lijing, Thibadeau, Judy, Wiener, John S., Routh, Jonathan C., Castillo, Heidi, Castillo, Jonathan, Freeman, Kurt A., Sawin, Kathleen J., Smith, Kathryn, Van Speybroeck, Alexander, Valdez, Rodolfo

“…Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors…”
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