Search Results - "Wiendl, Heinz"

Neurological immunotherapy in the era of COVID-19 — looking for consensus in the literature by Korsukewitz, Catharina, Reddel, Stephen W., Bar-Or, Amit, Wiendl, Heinz

“…The coronavirus disease 2019 (COVID-19) pandemic is concerning for patients with neuroimmunological diseases who are receiving immunotherapy. Uncertainty…”
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis by Schafflick, David, Xu, Chenling A., Hartlehnert, Maike, Cole, Michael, Schulte-Mecklenbeck, Andreas, Lautwein, Tobias, Wolbert, Jolien, Heming, Michael, Meuth, Sven G., Kuhlmann, Tanja, Gross, Catharina C., Wiendl, Heinz, Yosef, Nir, Meyer zu Horste, Gerd

“…Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF…”
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What Have Failed, Interrupted, and Withdrawn Antibody Therapies in Multiple Sclerosis Taught Us? by Krämer, Julia, Wiendl, Heinz

“…In the past two decades, monoclonal antibodies (mAbs) have revolutionized the treatment of multiple sclerosis (MS). However, a remarkable number of mAbs failed…”
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Teriflunomide and Its Mechanism of Action in Multiple Sclerosis by Bar-Or, Amit, Pachner, Andrew, Menguy-Vacheron, Francoise, Kaplan, Johanne, Wiendl, Heinz

“…Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments (DMTs) must both limit unwanted immune responses associated with disease…”
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Ofatumumab versus Teriflunomide in Multiple Sclerosis by Hauser, Stephen L, Bar-Or, Amit, Cohen, Jeffrey A, Comi, Giancarlo, Correale, Jorge, Coyle, Patricia K, Cross, Anne H, de Seze, Jerome, Leppert, David, Montalban, Xavier, Selmaj, Krzysztof, Wiendl, Heinz, Kerloeguen, Cecile, Willi, Roman, Li, Bingbing, Kakarieka, Algirdas, Tomic, Davorka, Goodyear, Alexandra, Pingili, Ratnakar, Häring, Dieter A, Ramanathan, Krishnan, Merschhemke, Martin, Kappos, Ludwig

“…In two identical trials involving a total of 1882 patients with multiple sclerosis, the human anti-CD20 monoclonal antibody ofatumumab was associated with a…”
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Immune reconstitution therapies: concepts for durable remission in multiple sclerosis by Lünemann, Jan D., Ruck, Tobias, Muraro, Paolo A., Bar-Or, Amit, Wiendl, Heinz

“…New so-called immune reconstitution therapies (IRTs) have the potential to induce long-term or even permanent drug-free remission in people with multiple…”
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Risks and risk management in modern multiple sclerosis immunotherapeutic treatment by Klotz, Luisa, Havla, Joachim, Schwab, Nicholas, Hohlfeld, Reinhard, Barnett, Michael, Reddel, Stephen, Wiendl, Heinz

“…In recent years, there has been a paradigm shift in the treatment of multiple sclerosis (MS) owing to the approval of a number of new drugs with very distinct…”
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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia by Beuker, Carolin, Schafflick, David, Strecker, Jan-Kolja, Heming, Michael, Li, Xiaolin, Wolbert, Jolien, Schmidt-Pogoda, Antje, Thomas, Christian, Kuhlmann, Tanja, Aranda-Pardos, Irene, A-Gonzalez, Noelia, Kumar, Praveen Ashok, Werner, Yves, Kilic, Ertugrul, Hermann, Dirk M., Wiendl, Heinz, Stumm, Ralf, Meyer zu Hörste, Gerd, Minnerup, Jens

“…Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the…”
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Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond by Ruck, Tobias, Bittner, Stefan, Wiendl, Heinz, Meuth, Sven G

“…Alemtuzumab is a humanized monoclonal antibody against CD52 (cluster of differentiation 52) and is approved for the therapy of relapsing-remitting multiple…”
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4-aminopyridine is not just a symptomatic therapy, it has a neuroprotective effect – No by Göbel, Kerstin, Wiendl, Heinz

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Acute bilateral optic/chiasm neuritis with longitudinal extensive transverse myelitis in longstanding stable multiple sclerosis following vector-based vaccination against the SARS-CoV-2 by Helmchen, Christoph, Buttler, Gesine M., Markewitz, Robert, Hummel, Katja, Wiendl, Heinz, Boppel, Tobias

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Effectiveness and safety of cladribine in MS: Real-world experience from two tertiary centres by Pfeuffer, Steffen, Rolfes, Leoni, Hackert, Jana, Kleinschnitz, Konstanze, Ruck, Tobias, Wiendl, Heinz, Klotz, Luisa, Kleinschnitz, Christoph, Meuth, Sven G, Pul, Refik

“…Background: Oral cladribine has been approved for the treatment of relapsing multiple sclerosis (MS) yet real-world evidence regarding its effectiveness and…”
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Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges by Schafflick, David, Wolbert, Jolien, Heming, Michael, Thomas, Christian, Hartlehnert, Maike, Börsch, Anna-Lena, Ricci, Alessio, Martín-Salamanca, Sandra, Li, Xiaolin, Lu, I-Na, Pawlak, Mathias, Minnerup, Jens, Strecker, Jan-Kolja, Seidenbecher, Thomas, Meuth, Sven G., Hidalgo, Andres, Liesz, Arthur, Wiendl, Heinz, Meyer zu Horste, Gerd

“…The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings suggest that these CNS-associated border tissues have complex immunological…”
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ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis by Montalban, Xavier, Gold, Ralf, Thompson, Alan J, Otero-Romero, Susana, Amato, Maria Pia, Chandraratna, Dhia, Clanet, Michel, Comi, Giancarlo, Derfuss, Tobias, Fazekas, Franz, Hartung, Hans Peter, Havrdova, Eva, Hemmer, Bernhard, Kappos, Ludwig, Liblau, Roland, Lubetzki, Catherine, Marcus, Elena, Miller, David H, Olsson, Tomas, Pilling, Steve, Selmaj, Krysztof, Siva, Aksel, Sorensen, Per Soelberg, Sormani, Maria Pia, Thalheim, Christoph, Wiendl, Heinz, Zipp, Frauke

“…Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is a need for a reference tool compiling…”
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Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic by Jacob, Saiju, Muppidi, Srikanth, Guidon, Amanda, Guptill, Jeffrey, Hehir, Michael, Howard, James F., Illa, Isabel, Mantegazza, Renato, Murai, Hiroyuki, Utsugisawa, Kimiaki, Vissing, John, Wiendl, Heinz, Nowak, Richard J.

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Mechanisms underlying lesion development and lesion distribution in CNS autoimmunity by Lindner, Maren, Klotz, Luisa, Wiendl, Heinz

“…It is widely accepted that development of autoimmunity in the central nervous system (CNS) is triggered by autoreactive T cells, that are activated in the…”
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Greater sensitivity to multiple sclerosis disability worsening and progression events using a roving versus a fixed reference value in a prospective cohort study by Kappos, Ludwig, Butzkueven, Helmut, Wiendl, Heinz, Spelman, Timothy, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, Koendgen, Harold, Belachew, Shibeshih, Trojano, Maria

“…Background: Confirmed Expanded Disability Status Scale (EDSS) progression occurring after a fixed-study entry baseline is a common measure of disability…”
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The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review by Göbel, Kerstin, Eichler, Susann, Wiendl, Heinz, Chavakis, Triantafyllos, Kleinschnitz, Christoph, Meuth, Sven G

“…The interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory…”
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Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society by Melzer, Nico, Ruck, Tobias, Fuhr, Peter, Gold, Ralf, Hohlfeld, Reinhard, Marx, Alexander, Melms, Arthur, Tackenberg, Björn, Schalke, Berthold, Schneider-Gold, Christiane, Zimprich, Fritz, Meuth, Sven G., Wiendl, Heinz

“…Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating…”
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Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis by Kappos, Ludwig, Wiendl, Heinz, Selmaj, Krzysztof, Arnold, Douglas L, Havrdova, Eva, Boyko, Alexey, Kaufman, Michael, Rose, John, Greenberg, Steven, Sweetser, Marianne, Riester, Katherine, O’Neill, Gilmore, Elkins, Jacob

“…In this trial, daclizumab high-yield process (a monoclonal antibody that binds to CD25 and modulates interleukin-2 signaling) was more effective than…”
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