Search Results - "Wiench, Karin"

Testing Metal-Oxide Nanomaterials for Human Safety by Landsiedel, Robert, Ma-Hock, Lan, Kroll, Alexandra, Hahn, Daniela, Schnekenburger, Jürgen, Wiench, Karin, Wohlleben, Wendel

“…Nanomaterials can display distinct biological effects compared with bulk materials of the same chemical composition. The physico‐chemical characterization of…”
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Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months by Ma-Hock, Lan, Treumann, Silke, Strauss, Volker, Brill, Sandra, Luizi, Frederic, Mertler, Michael, Wiench, Karin, Gamer, Armin O., van Ravenzwaay, Bennard, Landsiedel, Robert

“…Carbon nanotubes (CNT) are of great commercial interest. Theoretically, during processing and handling of CNT and in abrasion processes on composites…”
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Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials by Landsiedel, Robert, Ma-Hock, Lan, Hofmann, Thomas, Wiemann, Martin, Strauss, Volker, Treumann, Silke, Wohlleben, Wendel, Gröters, Sibylle, Wiench, Karin, van Ravenzwaay, Bennard

“…A standard short-term inhalation study (STIS) was applied for hazard assessment of 13 metal oxide nanomaterials and micron-scale zinc oxide. Rats were exposed…”
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Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats by Fabian, Eric, Landsiedel, Robert, Ma-Hock, Lan, Wiench, Karin, Wohlleben, Wendel, van Ravenzwaay, Ben

“…The tissue distribution and toxicity of intravenously administered nanoparticles of titanium dioxide (TiO 2 ) (>10 wt.% at <100 nm size) were investigated…”
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Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black by Ma-Hock, Lan, Strauss, Volker, Treumann, Silke, Küttler, Karin, Wohlleben, Wendel, Hofmann, Thomas, Gröters, Sibylle, Wiench, Karin, van Ravenzwaay, Bennard, Landsiedel, Robert

“…Carbon nanotubes, graphene, graphite nanoplatelets and carbon black are seemingly chemically identical carbon-based nano-materials with broad technological…”
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Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria by Keller, Jana, Wohlleben, Wendel, Ma-Hock, Lan, Strauss, Volker, Gröters, Sibylle, Küttler, Karin, Wiench, Karin, Herden, Christiane, Oberdörster, Günter, van Ravenzwaay, Bennard, Landsiedel, Robert

“…Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation…”
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Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms by Thoma, Tizia, Ma-Hock, Lan, Schneider, Steffen, Honarvar, Naveed, Treumann, Silke, Groeters, Sibylle, Strauss, Volker, Marxfeld, Heike, Funk-Weyer, Dorothee, Seiffert, Svenja, Wohlleben, Wendel, Dammann, Martina, Wiench, Karin, Lombaert, Noömi, Spirlet, Christine, Vasquez, Marie, Dewhurst, Nicole, Landsiedel, Robert

“…Significant variations exist in the forms of ZnO, making it impossible to test all forms in in vivo inhalation studies. Hence, grouping and read-across is a…”
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Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance by Ma-Hock, Lan, Burkhardt, Silke, Strauss, Volker, Gamer, Armin O., Wiench, Karin, van Ravenzwaay, Bennard, Landsiedel, Robert

“…Evidence suggests that short-term inhalation studies may provide comparable prediction of respiratory tract toxicity to 90-day studies, presenting the…”
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Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations by Landsiedel, Robert, Ma-Hock, Lan, Van Ravenzwaay, Ben, Schulz, Markus, Wiench, Karin, Champ, Samantha, Schulte, Stefan, Wohlleben, Wendel, Oesch, Franz

“…Abstract Titanium dioxide and zinc oxide nanomaterials, used as UV protecting agents in sunscreens, were investigated for their potential genotoxicity in in…”
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In vitro genotoxicity studies: n-Butyl acrylate L5178Y mouse lymphoma (TK+/− locus assay), 2-Ethylhexyl acrylate gene mutation assay in Chinese hamster V79 cells, and 2-Ethylhexyl acrylate micronucleus test in human lymphocytes by Murphy, Sandra, Ellis-Hutchings, Robert, Finch, Lavorgie, Welz, Stefanie, Wiench, Karin

“…Available point mutation tests have shown inconsistent results with various acrylates. Most of those tests were performed prior to OECD guidelines and…”
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Acute and chronic effects of nano- and non-nano-scale TiO2 and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna by Wiench, Karin, Wohlleben, Wendel, Hisgen, Volker, Radke, Kristin, Salinas, Edward, Zok, Sabine, Landsiedel, Robert

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An in vitro alveolar macrophage assay for predicting the short-term inhalation toxicity of nanomaterials by Wiemann, Martin, Vennemann, Antje, Sauer, Ursula G, Wiench, Karin, Ma-Hock, Lan, Landsiedel, Robert

“…Most in vitro studies investigating nanomaterial pulmonary toxicity poorly correlate to in vivo inhalation studies. Alveolar macrophages (AMs) play an…”
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A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates by Suh, Mina, Proctor, Deborah, Chappell, Grace, Rager, Julia, Thompson, Chad, Borghoff, Susan, Finch, Lavorgie, Ellis-Hutchings, Robert, Wiench, Karin

“…•Review identified 135 studies and HTS data for assessing carcinogenicity.•Acrylates are metabolized rapidly by carboxylesterase hydrolysis & GSH…”
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Toxico-/biokinetics of nanomaterials by Landsiedel, Robert, Fabian, Eric, Ma-Hock, Lan, Wohlleben, Wendel, Wiench, Karin, Oesch, Franz, van Ravenzwaay, Ben

“…Nanomaterials (NM) offer great technological advantages but their risks to human health are still under discussion. For toxicological testing and evaluation,…”
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Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping by Landsiedel, Robert, Ma-Hock, Lan, Wiench, Karin, Wohlleben, Wendel, Sauer, Ursula G.

“…As presented at the 2016 TechConnect World Innovation Conference on 22–25 May 2016 in Washington DC, USA, the European Centre for Ecotoxicology and Toxicology…”
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Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers by Landsiedel, Robert, Kapp, Maike Diana, Schulz, Markus, Wiench, Karin, Oesch, Franz

“…Nanomaterials display novel properties to which most toxicologists have not consciously been exposed before the advent of their practical use. The same…”
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A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) by Arts, Josje H.E., Hadi, Mackenzie, Irfan, Muhammad-Adeel, Keene, Athena M., Kreiling, Reinhard, Lyon, Delina, Maier, Monika, Michel, Karin, Petry, Thomas, Sauer, Ursula G., Warheit, David, Wiench, Karin, Wohlleben, Wendel, Landsiedel, Robert

“…•DF4nanoGrouping is a functionality-driven concept to group and test nanomaterials.•It addresses all aspects of a nanomaterial’s life cycle and biological…”
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On the Lifecycle of Nanocomposites: Comparing Released Fragments and their In-Vivo Hazards from Three Release Mechanisms and Four Nanocomposites by Wohlleben, Wendel, Brill, Sandra, Meier, Matthias W., Mertler, Michael, Cox, Gerhard, Hirth, Sabine, von Vacano, Bernhard, Strauss, Volker, Treumann, Silke, Wiench, Karin, Ma-Hock, Lan, Landsiedel, Robert

“…Nanocomposites are the dominating class of nanomaterials to come into consumer contact, and were in general assumed to pose low risk. The first data is now…”
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Critical evaluation of 2-ethylhexyl acrylate dermal carcinogenicity studies using contemporary criteria by Murphy, Sandra, Ellis-Hutchings, Robert, Finch, Lavorgie, Welz, Stefanie, Wiench, Karin

“…Skin tumors have been observed in C3H/HeJ mice following treatment with high and strongly irritating concentrations of 2-ethylhexyl acrylate (2-EHA). Dermal…”
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Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice by Arts, Josje H.E., Irfan, Muhammad-Adeel, Keene, Athena M., Kreiling, Reinhard, Lyon, Delina, Maier, Monika, Michel, Karin, Neubauer, Nicole, Petry, Thomas, Sauer, Ursula G., Warheit, David, Wiench, Karin, Wohlleben, Wendel, Landsiedel, Robert

“…Case studies covering carbonaceous nanomaterials, metal oxide and metal sulphate nanomaterials, amorphous silica and organic pigments were performed to assess…”
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