Search Results - "Wiemer, Andrew J."

Stepping forward in antibody-drug conjugate development by Jin, Yiming, Schladetsch, Megan A., Huang, Xueting, Balunas, Marcy J., Wiemer, Andrew J.

“…Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody, a linker and a small-molecule payload. ADCs use the specificity of the…”
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Prodrugs of phosphonates and phosphates: crossing the membrane barrier by Wiemer, Andrew J, Wiemer, David F

“…A substantial portion of metabolism involves transformation of phosphate esters, including pathways leading to nucleotides and oligonucleotides, carbohydrates,…”
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Antibody–Drug Conjugates in the Pipeline for Treatment of Melanoma: Target and Pharmacokinetic Considerations by Lami, Ina, Wiemer, Andrew J.

“…Melanoma is an aggressive, rapidly developing form of skin cancer that affects about 22 per 100,000 individuals. Treatment options for melanoma patients are…”
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A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing by Karunakaran, Mohindar M., Subramanian, Hariharan, Jin, Yiming, Mohammed, Fiyaz, Kimmel, Brigitte, Juraske, Claudia, Starick, Lisa, Nöhren, Anna, Länder, Nora, Willcox, Carrie R., Singh, Rohit, Schamel, Wolfgang W., Nikolaev, Viacheslav O., Kunzmann, Volker, Wiemer, Andrew J., Willcox, Benjamin E., Herrmann, Thomas

“…Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens…”
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Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition by Agabiti, Sherry S., Li, Jin, Dong, Willie, Poe, Michael M., Wiemer, Andrew J.

“…Notch proteins drive oncogenesis of many cancers, most prominently T-cell acute lymphoblastic leukemia (T-ALL). Because geranylgeranylated Rab proteins…”
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Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand by Foust, Benjamin J, Poe, Michael M, Lentini, Nicholas A, Hsiao, Chia-Hung Christine, Wiemer, Andrew J, Wiemer, David F

“…Studies of aryl phosphonate derivatives of a butyrophilin 3A1 ligand have resulted in identification of a potent stimulant of Vγ9 Vδ2 T cells. This compound, a…”
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Generation of effector Vγ9Vδ2 T cells and evaluation of their response to phosphoantigen-loaded cells by Hsiao, Chia-Hung Christine, Wiemer, Andrew J.

“…Vγ9Vδ2 T cells are non-canonical T cells that use their T cell receptor to detect phosphoantigens bound to the internal domain of the HMBPP receptor…”
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Isoprenoid metabolism as a therapeutic target in gram-negative pathogens by Wiemer, Andrew J, Hsiao, Chia-Hung Christine, Wiemer, David F

“…Gram-negative Enterobacteria include a variety of human pathogens, perhaps most notably E. coli, Salmonella, Shigella, Yersinia, and Proteus. While there are…”
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Structure‐Activity Relationships of Butyrophilin 3 Ligands by Wiemer, Andrew J.

“…Phosphoantigens (pAgs) are small phosphorus‐containing molecules that stimulate Vγ9Vδ2 T cells with sub‐nanomolar cellular potency. Recent work has revealed…”
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Metabolic Efficacy of Phosphate Prodrugs and the Remdesivir Paradigm by Wiemer, Andrew J

“…Drugs that contain phosphates (and phosphonates or phosphinates) have intrinsic absorption issues and are therefore often delivered in prodrug forms to promote…”
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The intermediate enzymes of isoprenoid metabolism as anticancer targets by Wiemer, Andrew J, Hohl, Raymond J, Wiemer, David F

“…Inhibitors of isoprenoid biosynthesis are widely used to treat human disease including statins and nitrogenous bisphosphonates. Due to the importance of core…”
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New Technologies Bloom Together for Bettering Cancer Drug Conjugates by Jin, Yiming, Edalatian Zakeri, Shahab, Bahal, Raman, Wiemer, Andrew J

“…Drug conjugates, including antibody-drug conjugates, are a step toward realizing Paul Ehrlich's idea from over 100 years ago of a "magic bullet" for cancer…”
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Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1 by Singh, Rohit, Rani, Sarita, Jin, Yiming, Hsiao, Chia-Hung Christine, Wiemer, Andrew J.

“…Phosphoantigens (pAgs) induce conformational changes after binding to the intracellular region of BTN3A1 which result in its clustering with BTN2A1, forming an…”
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Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex by Hsiao, Chia-Hung Christine, Nguyen, Khiem, Jin, Yiming, Vinogradova, Olga, Wiemer, Andrew J

“…The ligand-bound (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) receptor (BTN3A1 and BTN2A1) is detectable by the T cell receptor (TCR) of Vγ9Vδ2…”
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Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes by Dudakovic, Amel, Wiemer, Andrew J, Lamb, Kimberly M, Vonnahme, Laura A, Dietz, Sara E, Hohl, Raymond J

“…Inhibitors of isoprenoid synthesis are widely used for treatment of human diseases, including hypercholesterolemia and osteoporosis, and they have the…”
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A power law function describes the time- and dose-dependency of Vγ9Vδ2 T cell activation by phosphoantigens by Hsiao, Chia-Hung Christine, Wiemer, Andrew J.

“…[Display omitted] Phosphoantigens stimulate Vγ9Vδ2 T cells after binding to BTN3A1 in target cells and cell–cell contact. We evaluated phosphoantigens…”
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Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1 by Nguyen, Khiem, Jin, Yiming, Howell, Matthew, Hsiao, Chia-Hung Christine, Wiemer, Andrew J, Vinogradova, Olga

“…Intracellular binding of small-molecule phospho-Ags to the HMBPP receptor complex in infected cells leads to extracellular detection by T cells expressing the…”
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Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization by Singh, Umed, Pawge, Girija, Rani, Sarita, Hsiao, Chia-Hung Christine, Wiemer, Andrew J, Wiemer, David F

“…Activation of Vγ9Vδ2 T cells with butyrophilin 3A1 (BTN3A1) agonists such as ( )-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) has the potential to boost…”
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HMBPP Analog Prodrugs Bypass Energy-Dependent Uptake To Promote Efficient BTN3A1-Mediated Malignant Cell Lysis by V gamma 9V delta 2 T Lymphocyte Effectors by Kilcollins, Ashley M, Li, Jin, Hsiao, Chia-Hung Christine, Wiemer, Andrew J

“…V gamma 9V delta 2 effector T cells lyse cells in response to phosphorus-containing small molecules, providing primates a unique route to remove infected or…”
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The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region by Nguyen, Khiem, Li, Jin, Puthenveetil, Robbins, Lin, Xiaochen, Poe, Michael M., Christine Hsiao, Chia‐Hung, Vinogradova, Olga, Wiemer, Andrew J.

“…Small isoprenoid diphosphates, such as (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl diphosphate (HMBPP), are ligands of the internal domain of BTN3A1. Ligand binding in…”
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