Search Results - "Wielinga, Peter Y."

Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models by Kleemann, Robert, Verschuren, Lars, Morrison, Martine, Zadelaar, Susanne, van Erk, Marjan J, Wielinga, Peter Y, Kooistra, Teake

“…Abstract Objective Polyphenols such as quercetin may exert several beneficial effects, including those resulting from anti-inflammatory activities, but their…”
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Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin by Salic, Kanita, Morrison, Martine C, Verschuren, Lars, Wielinga, Peter Y, Wu, Lijun, Kleemann, Robert, Gjorstrup, Per, Kooistra, Teake

“…Abstract Background and aims Besides LDL-cholesterol, local vascular inflammation plays a key role in atherogenesis. Efficient therapies to treat the…”
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Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis by Salic, Kanita, Gart, Eveline, Seidel, Florine, Verschuren, Lars, Caspers, Martien, van Duyvenvoorde, Wim, Wong, Kari E, Keijer, Jaap, Bobeldijk-Pastorova, Ivana, Wielinga, Peter Y, Kleemann, Robert

“…Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments…”
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A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice by Schoemaker, Marieke H, Kleemann, Robert, Morrison, Martine C, Verheij, Joanne, Salic, Kanita, van Tol, Eric A F, Kooistra, Teake, Wielinga, Peter Y

“…Obesity frequently associates with the development of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Chronic inflammation in white adipose…”
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Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil by Morrison, Martine C, Mulder, Petra, Stavro, P Mark, Suárez, Manuel, Arola-Arnal, Anna, van Duyvenvoorde, Wim, Kooistra, Teake, Wielinga, Peter Y, Kleemann, Robert

“…As dietary saturated fatty acids are associated with metabolic and cardiovascular disease, a potentially interesting strategy to reduce disease risk is…”
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Vaccination against GIP for the treatment of obesity by Fulurija, Alma, Lutz, Thomas A, Sladko, Katja, Osto, Melania, Wielinga, Peter Y, Bachmann, Martin F, Saudan, Philippe

“…According to the WHO, more than 1 billion people worldwide are overweight and at risk of developing chronic illnesses, including cardiovascular disease, type 2…”
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Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance by Kleemann, Robert, van Erk, Marjan, Verschuren, Lars, van den Hoek, Anita M, Koek, Maud, Wielinga, Peter Y, Jie, Annie, Pellis, Linette, Bobeldijk-Pastorova, Ivana, Kelder, Thomas, Toet, Karin, Wopereis, Suzan, Cnubben, Nicole, Evelo, Chris, van Ommen, Ben, Kooistra, Teake

“…The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely…”
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Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21? by Morrison, Martine C., Yakala, Gopala K., Liang, Wen, Wielinga, Peter Y., Salic, Kanita, van Koppen, Arianne, Tomar, Tushar, Kleemann, Robert, Heeringa, Peter, Kooistra, Teake

“…Obesity-related albuminuria is associated with decline of kidney function and is considered a first sign of diabetic nephropathy. Suggested factors linking…”
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Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice by Morrison, Martine C., Verschuren, Lars, Salic, Kanita, Verheij, Joanne, Menke, Aswin, Wielinga, Peter Y., Iruarrizaga‐Lejarreta, Marta, Gole, Laurent, Yu, Wei‐Miao, Turner, Scott, Caspers, Martien P.M., Martínez‐Arranz, Ibon, Pieterman, Elsbet, Stoop, Reinout, van Koppen, Arianne, van den Hoek, Anita M., Mato, José M., Hanemaaijer, Roeland, Alonso, Cristina, Kleemann, Robert

“…Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH)…”
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Coordinated and interactive expression of genes of lipid metabolism and inflammation in adipose tissue and liver during metabolic overload by Liang, Wen, Tonini, Giulia, Mulder, Petra, Kelder, Thomas, van Erk, Marjan, van den Hoek, Anita M, Mariman, Rob, Wielinga, Peter Y, Baccini, Michela, Kooistra, Teake, Biggeri, Annibale, Kleemann, Robert

“…Chronic metabolic overload results in lipid accumulation and subsequent inflammation in white adipose tissue (WAT), often accompanied by non-alcoholic fatty…”
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Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation by Wielinga, Peter Y, Yakala, Gopala K, Heeringa, Peter, Kleemann, Robert, Kooistra, Teake

“…Alternate day calorie restriction (CR) has been shown to be almost as beneficial as daily CR. The question arises whether this concept is also applicable to…”
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Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice by Radonjic, Marijana, Wielinga, Peter Y, Wopereis, Suzan, Kelder, Thomas, Goelela, Varshna S, Verschuren, Lars, Toet, Karin, van Duyvenvoorde, Wim, van der Werff van der Vat, Bianca, Stroeve, Johanna H M, Cnubben, Nicole, Kooistra, Teake, van Ommen, Ben, Kleemann, Robert

“…Excess caloric intake leads to metabolic overload and is associated with development of type 2 diabetes (T2DM). Current disease management concentrates on risk…”
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Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE∗ 3Leiden mice by Morrison, Martine C, Liang, Wen, Mulder, Petra, Verschuren, Lars, Pieterman, Elsbet, Toet, Karin, Heeringa, Peter, Wielinga, Peter Y, Kooistra, Teake, Kleemann, Robert

“…Background & Aims Anthocyanins may have beneficial effects on lipid metabolism and inflammation and are demonstrated to have hepatoprotective properties in…”
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Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet by Yakala, Gopala K., Wielinga, Peter Y., Suarez, Manuel, Bunschoten, Annelies, van Golde, Jolanda M., Arola, Lluis, Keijer, Jaap, Kleemann, Robert, Kooistra, Teake, Heeringa, Peter

“…Scope Dietary intake of cocoa and/or chocolate has been suggested to exhibit protective cardiovascular effects although this is still controversial. The aim of…”
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Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function by Yakala, Gopala K, van der Heijden, Roel, Molema, Grietje, Schipper, Martin, Wielinga, Peter Y, Kleemann, Robert, Kooistra, Teake, Heeringa, Peter

“…An Alternating high- cholesterol dietary regimen has proven to be beneficial when compared to daily high- cholesterol feeding. In the current study we explored…”
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Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice by Mulder, Petra, Morrison, Martine C., Verschuren, Lars, Liang, Wen, van Bockel, J. Hajo, Kooistra, Teake, Wielinga, Peter Y., Kleemann, Robert

“…Obesity is associated with chronic low-grade inflammation that drives the development of metabolic diseases, including non-alcoholic fatty liver disease…”
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Central amylin acts as an adiposity signal to control body weight and energy expenditure by Wielinga, Peter Y, Löwenstein, Christian, Muff, Sabine, Munz, Manuela, Woods, Stephen C, Lutz, Thomas A

“…Abstract The pancreatic B-cell hormone amylin has been proposed to be both a satiation signal and an adiposity signal. The effects of peripheral amylin on…”
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A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice by Verschuren, Lars, Wielinga, Peter Y, van Duyvenvoorde, Wim, Tijani, Samira, Toet, Karin, van Ommen, Ben, Kooistra, Teake, Kleemann, Robert

“…Chronic inflammation and proatherogenic lipids are important risk factors of cardiovascular disease (CVD). Specific dietary constituents such as polyphenols…”
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The acute effect of amylin and salmon calcitonin on energy expenditure by Wielinga, Peter Y, Alder, Bettina, Lutz, Thomas A

“…Abstract The pancreatic B-cell hormone amylin is known to be involved in the regulation of meal ending satiation and it also shares typical features of…”
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Comparison of the effects of three different (-)-hydroxycitric acid preparations on food intake in rats by Louter-van de Haar, Johanna, Wielinga, Peter Y, Scheurink, Anton J W, Nieuwenhuizen, Arie G

“…Studies on the effects of (-)-hydroxycitric acid (HCA) in humans are controversial. As differences in the HCA preparations may contribute to this apparent…”
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